TiO2/MXene-Assisted LDI-MS for Urine Metabolic Profiling in Urinary Disease

Cancer remains an intractable medical problem. Rapid diagnosis and identification of cancer are critical to differentiate it from nonmalignant diseases. High-throughput biofluid metabolic analysis has potential for cancer diagnosis. Nevertheless, the present metabolite analysis method does not meet the demand for high-throughput screening of diseases. Herein, a high-throughput, cost-effective, and noninvasive urine metabolic profiling method based on TiO₂/MXene-assisted laser desorption/ionization mass spectrometry (LDI-MS) is presented for the efficient screening of bladder cancer (BC) and nonmalignant urinary disease. Combined with machine learning, TiO₂/MXene-assisted LDI-MS enables high diagnostic accuracy (96.8%) for the classification of patient groups (including 47 BC and 46 ureteral calculus (UC) patients) from healthy controls (113 cases). In addition, BC patients can also be identified from noncancerous UC individuals with an accuracy of 88.3% in the independent test cohort. Furthermore, metabolite variations between BC and UC individuals are investigated based on relative quantification, and related pathways are also discussed. These results suggest that this method, based on urine metabolic patterns, provides a potential tool for rapidly distinguishing urinary diseases and it may pave the way for precision medicine.     

变长线扫描选择性激光烧结快速成型工艺的质量和效率优势分析

本文分析变长线扫描选择性激光烧结快速成型工艺对点扫描工艺的质量和效率优势.对二者光学系统结构作分析对比,对焦斑和线束上的功率密度作计算对比.变长线扫描系统采用的扫描方式和聚焦元件使线束宽度小且恒定,线束功率密度与点扫描焦斑的相当.变长线扫描选择性激光烧结快速成型工艺的质量优势是明显的,效率比点扫描工艺提高一倍左右.     

大窝山隧道进口围岩快速掘进施工组织与管理

结合工程概况及工程特点,从机械设备配置、劳动力组织、现场管理等方面介绍了大窝山隧道进口Ⅱ级,Ⅲ级围岩段的快速掘进施工组织与管理措施,为类似隧道的快速掘进施工组织与管理提拱了相关经验.     

EFFECT OF STREAMLINE CURVATURE AND SOME OTHER CONDITIONS ON THE TURBULENT STRUCTURES IN THE OTHER REGION OF AN OBSTACLE

ＥＦＦＥＣＴＯＦＳＴＲＥＡＭＬＩＮＥＣＵＲＶＡＴＵＲＥＡＮＤＳＯＭＥＯＴＨＥＲＣＯＮＤＩＴＩＯＮＳＯＮＴＨＥＴＵＲＢＵＬＥＮＴＳＴＲＵＣＴＵＲＥＳＩＮＴＨＥＯＴＨＥＲＲＥＧＩＯＮＯＦＡＮＯＢＳＴＡＣＬＥＬｉｕＳｈｉ－ｈｅ（ＷｕｈａｎＵｎｉｖｅｒｓｉｔ...     

隧道二次衬砌混凝土快速施工技术

结合某隧道施工实例，阐述了混凝土快速施工方案，探索了采用机械化混凝土输送系统配合整体液压衬砌台车进行混凝土快速施工技术，并提出了系统的设计、选形与配套措施。     

Structure of rapidly solidified aluminum alloys

This paper is a summary of an extensive research program carried out by the authors on the structure of rapidly solidified aluminum alloys; and a comparison with the work of others also involved in this field. The paper discusses the changes in the dendritic and non-dendritic structure of the matrix at cooling rates from 10^–3 to 10¹⁰ K/s and discusses the hetergeneity of the structure caused by interdendritic-segretion during solidification.     

YAG激光熔覆的研究现状与发展趋势

本文介绍了YAG激光熔覆的特点，并与CO2激光进行了比较，显示了YAG激光熔覆的优势和潜力。叙述了YAG激光熔覆的研究进展及其应用前景。     

离子注入半导体的快速热退火与SOI技术

自1977年以来,为了摸索离子注入半导体的新退火方法,各国学者进行了大量的研究工作。这种努力是从激光退火的研究开始的。激光与半导体材料相互作用的研究,已派生出若干很有生命力的应用项目,其中,快速热退火、SOI(Semiconductor on Insulator)技术等已显示了重要的应用前景,并正在走向实用化。     

Pd-Ge contact to n-GaAs with the TiW diffusion barrier

Pd-Ge based ohmic contact to n-GaAs with a TiW diffusion barrier was investigated. Electrical analysis as well as Auger electron spectroscopy and the scanning electron microscopy were used to study the contact after it was subjected to different furnace and rapid thermal annealing and different aging steps. All analyses show that TiW can act as a good barrier metal for the Au/Ge/Pd/n-GaAs contact system. A value of 1.45 × 10⁻⁶ Ω-cm² for the specific contact resistance was obtained for the Au/TiW/Ge/Pd/n-GaAs contact after it was rapid thermally annealed at 425°C for 90 s. It can withstand a thermal aging at 350°C for 40 h with its ρ_c increasing to 2.94 × 10⁻⁶Ω-cm² and for an aging at 410°C for 40 h with its ρ_c increasing to 1.38 × 10⁻⁵ Ω-cm².     

Targets and methods for the detection of processed animal proteins in animal feedstuffs

Bovine spongiform encephalopathy (BSE), or ‘mad cow disease’, is one of several transmissable spongiform encephalopathies (TSEs) known to affect certain mammals and is spread through the ingestion of infected animal tissue. It is believed that the inadvertent contamination of meat and bone meal (MBM) with infected animal tissue and the subsequent use of this material as a feed supplement contributed to the spread of the disease in cattle. As a result, the use of processed animal proteins (PAPs) in animal feeds is regulated in many parts of the world. Although feed testing is the only definitive means to certify compliance, regulatory compliance often relies solely on paper certification. Recently, rapid methods have become available that can be used by regulators to determine compliance during routine inspections. We describe a rapid, immunochromatographic strip test that can detect 0.1% MBM in animal feed. The test takes 15 min to perform and large numbers of samples can be screened for PAPs simultaneously.