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排序方式: 共有611条查询结果,搜索用时 30 毫秒
1.
Synthesis of novel nonionic surfactants has attracted attention of synthetic chemists due to the issues of the currently used commercial surfactants. The synthesis of three biocompatible triazole-based nonionic surfactants is reported for nanovesicular drug loading. The surfactants were synthesized in a three-step reaction and characterized using 1HNMR and mass spectroscopy techniques. They were investigated for their critical micelle concentration (CMC) using a UV–Visible spectrophotometer. Their biocompatibility was investigated against cell culture and in blood. All the synthesized nonionic surfactants were further explored for their nanovesicular drug loading using clarithromycin as a model hydrophobic drug. Nonionic surfactants revealed lower CMC in 35–45 μM and were less hemolytic and cytotoxic. They were capable of self-assembling in nanosize niosomal vesicles encapsulating increased amounts of drug. The results suggest the synthesized nonionic surfactants as biocompatible nanotechnology-based drug-delivery vehicles. 相似文献
2.
Md. Abdur Rahim Shamim Mahbub Md. Kamrul Islam Sk. Md. Ali Ahsan Shahed Rana Malik Abdul Rub Anish Khan Md. Anamul Hoque 《Journal of surfactants and detergents》2020,23(2):457-470
Conductometric and cloud point (CP) measurement studies have been performed to investigate the interaction of tetradecyltrimethylammonium bromide (TTAB) and Triton® X-100 (TX-100) with ciprofloxacin hydrochloride (CFH) in different solvents over the temperature range of 295.15–315.15 K. CFH is used for the treatment of various bacterial infections. The observed critical micelle concentration (CMC) values of TTAB were found to be reduced in the presence of electrolytes (Na2SO4/Na3PO4), and this reduction proceeds with the elevation of salt concentration. The order of the CMC of TTAB follows the trend: > >. The observed CMC values of TTAB were found to increase with increasing temperature and decrease with increasing concentration of CFH in aqueous medium. The values of Gibbs free energy of micellization () for the TTAB/TTAB + CFH mixture were found to be negative, implying spontaneous micellization. The estimated CP of TX-100 decreases with increasing concentration of TX-100 in aqueous medium. The CP values first decrease with increasing concentration of CFH and then increase at higher concentration of CFH almost in all cases investigated. The values of free energy of clouding were found to be positive in all cases studied implying that phase separation of TX-100 was nonspontaneous. The other thermodynamic parameters associated with the micellization of TTAB and the phase separation of TX-100 were estimated and explained. 相似文献
3.
4.
Nabel?A.?NegmEmail author Salwa?M.?I.?Morsy 《Journal of surfactants and detergents》2005,8(3):283-287
A weight loss technique was used to determine the corrosion inhibition efficiency of synthesized alkyl mono-and dibenzoate
triethanolammonium bromide derivatives (TEAMB, TEADB) in an acidic medium (2 N HCl) at different doses (50, 100, and 200 ppm).
The results showed that monoderivatives had a higher corrosion inhibition efficiency than diderivatives. The results were
correlated with several factors, including the alkyl chain length of the hydrophobic chains, interfacial tension (IT), critical
micelle concentration (CMC), and adsorption free energy of these inhibitors. Increasing the geometric length of the alkyl
chains in the synthesized inhibitors had an increasing effect on their corrosion inhibition efficiency, whereas decreasing
the CMC and IT had an increasing effect on their tendency toward corrosion inhibition. The number of hydrophobic chains attached
to the inhibitor molecules had a vital influence on their efficiency as corrosion inhibitors. 相似文献
5.
用Modbus协议实现DCS与PLC之间的串行通讯 总被引:2,自引:0,他引:2
本文主要通过讨论HoneywellPKS集散系统与Ingersoll—randCMC可编程序控制器之间实现串行通讯所需的Modbus协议,硬件配置,软件组态以及连线,来说明用Modbus协议实现DCS与PLC之间串行通讯的一般方法及注意事项。 相似文献
6.
Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed. 相似文献
7.
Instant messaging (IM) has become a popular and important mode of staying in touch for teens and young adults. It allows for easy, frequent and lightweight interaction that contributes to building and sustaining friendships, as well as coordinating social activities. Despite the initial appeal of IM, however, some have found it too distracting and have changed their usage or abandoned it. I interviewed 21 former users of IM about their adoption, usage and eventual abandonment of the technology. Results show that participants were initially attracted to features of IM that enabled them to maximize their use of leisure time via easy and frequent interaction with their friends, but that, in a different usage context, these same features became distracting and annoying. Participants adapted their behavior to avoid these drawbacks, but IM did not support these adaptations effectively. In particular, IM did not allow for control over interruptions, which became more important as their contact lists grew and social time became scarce; and they ultimately abandoned the technology. These results point to a need for understanding use beyond adoption, and a theoretical and practical focus on understanding the adaptation and changing utility that accompany long-term usage of technologies. 相似文献
8.
The goal of this study is to explore how experiencing flow with IM, an Internet-based communication technology, can facilitate an individual’s perception on creativity. We argue that certain capabilities in IM, telepresence and perceived control, provide users a means to experience flow. We further investigate whether flow and its outcomes, positive affect and exploratory behavior have any influence on the perception of creativity of the users. Using an online survey with 207 observations we found that user’s perceived control over the technology and its ability to transport the user to a virtual environment were shown to facilitate the experience of flow. We found that flow in itself does not influence perceived expected creativity in its users but does indirectly influence perceived expected creativity through exploratory behavior and positive affect. From these initial findings we believe that our study provides implications for both users and designers on IT. Furthermore, managers can apply the findings during implementation and use of interactive information technologies for communications in the workplace. 相似文献
9.
《Behaviour & Information Technology》2012,31(6):489-496
Two experiments aimed to explore the general usability of filenames that were either chosen for personal use or designed for another user, within a document-filing scenario. Both experiments revealed a strong benefit for using self-chosen names over using names that were chosen by another for their personal use. However, both experiments also showed that participants could to some extent adapt their chosen names for use by a wider population. In experiment one, users could recall these ‘designed’ names more accurately than names that had been chosen for personal use by another (although this difference was not evident in a recognition test). Experiment two supported this effect; names designed for general use were more accurately recalled by another than the names designed for self-use after two sessions of use. Names designed for general use employed higher frequency words than did the self-chosen names, which supports the view that the benefit for self-chosen names partly lies in their exploitation of idiosyncratic associations. 相似文献
10.
研究了脂肪胺聚氧乙烯醚(AE18)和十二烷基苯磺酸钠(LAS)在水溶液中相互作用。通过表面张力法测定了AE18和LAS不同比例下的临界胶束浓度(CMC)。两种表面活性剂以任何比例复配时,复配体系的CMC都明皿低于LAS的CMC;并且在摩尔比n(LAS):n(AE18)=1:9时,混合体系的CMC比任何单一表面活性剂CMC都低。复配体系达到CMC时的表面张力(γCNC)介于两种表面活性剂之间。运用Clint提出的理想混合胶团公式对CMC值进行了计算,与CMC实验值比较.发现随AE18摩尔分数的增加,CMC的实验值与计算值相近。 相似文献