The generalized discrete ‐centroid problem

The ‐centroid problem or leader–follower problem is generalized considering different customer choice rules where a customer may use facilities belonging to different firms, if the difference in travel distance (or time) is small enough. Assuming essential goods, some particular customer choice rules are analyzed. Linear programming formulations for the generalized ‐medianoid and ‐centroid problems are presented and an exact solution approach is applied. Some computational examples are included.     

2-Phenyloxazole-4-carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase B

A series of 2-phenyloxazoles bearing an amide group at position 4 were designed and synthesized for evaluation as potential inhibitors of human recombinant monoamine oxidases (hrMAOs). Results of kinetics experiments demonstrated that all compounds behave as competitive MAO inhibitors, with good selectivity toward the MAO-B isoform. The most potent and selective derivatives are characterized by inhibition constant (K_i) values in the sub-micromolar range and a good selectivity index (K_{i MAO-A}/K_{i MAO-B}>50). Some derivatives were also found to be able to inhibit MAO activity in nerve growth factor (NGF)-differentiated PC12 cells, taken as a model of neuronal cells. In particular, 2-(2-hydroxyphenyl)-N-phenyloxazole-4-carboxamide (compound 4 a ) may be a promising new scaffold, exerting the highest selectivity and inhibitory effect toward MAOs in NGF-differentiated PC12 cell lysates, without compromising cell viability. Molecular docking analysis allowed a rationalization of the experimentally observed binding affinity and selectivity.     

Denying History: Comment.

Comments on an article by Eidelson and Eidelson (see record 2003-03645-004) which made an important contribution, at a critical juncture, to the discussion of international conflicts by identifying core dimensions that allow for the systematic examination of the problem. Their article also posed a danger that mirrors a disturbing trend in the public discourse about conflicts and injustice. In response to the recent escalation of international violence and years of mixed results of engagement in debates centered around grievances of injustice (such as the Palestinian-Israeli conflict), many politicians, pundits, and scholars have advocated addressing conflicts by separating them from the underlying grievances and the ongoing injustice. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

制造业企业竞争情报系统建设浅析

讨论了制造业企业信息化进程中包含竞争情报系统的必要性。论述了该类企业竞争情报系统的内涵及功能特征。较详细地介绍了相应系统常用外部数据资源内容及各自应用特点;此外本文还简要地说明了该类系统现有开发支持工具软件、开发关键步骤等内容。     

神经网络在缺陷识别中的应用

为了准确、快速地进行缺陷识别，介绍了一种新型的前馈神经网络模型，即径向基概率神经网络。与以往的算法相比，该方法具有分类识别精度高且速度快的优点。仿真获得了很好的结果。     

浅谈抽水蓄能电站的特点及其优越性

本文介绍了国外抽水蓄能电站的发展过程与现状，修建抽水蓄能电站的八大优点。为了改善我省电力系统的运行条件，提出了在我省修建抽水蓄能电站的四点建议。     

浙江省铜加工产业国际竞争力因素分析、应对思路

文章从提高铜加工产业国际竞争力角度,比较宏观地分析了浙江省铜加工产业国际竞争力提高的环境、积极与消极因素,针对性地提出了提升浙江省铜加工产业国际竞争力的应对思路。     

浅议实施差异化战略的措施

随着我国市场的开放，企业面对的竞争日趋激烈，而且企业的竞争优势主要表现为差异化。根据差异化与买方价值的关系，通过技术创新、观念创新实施差异化。     

某半导体产品的设计和快速实现研究

研究了产品开发及快速实现过程中任务获取、任务分配、进度的协调、信息传输等相关问题,并以某半导体产品为例,进行了产品的设计和快速实现,为缩短产品开发和上市周期、提高产品的市场竞争力积累经验。     

试论入世对中国氧化铝工业的影响

随着中国加入WTO，给企业带来了发展的机会，也带来了挑战。本文通过对中国氧化铝工业的现状及其与世界水平的差距的分析，阐明了入世后随着关税等贸易壁垒的消除，国内、国际市场的竞争更加激烈。明确指出了我国氧化铝工业面临的多重挑战，以及给中国氧化铝工业带来的机遇。强调充分利用WTO给企业创设的权利，借入世东风，促进我国氧化铝工业快速发展，只有发展，中国氧化铝工业才有出路。