From IP to Start-up： Building a Robust Life Science Incubator

An incubator is an organization that supports new ventures to grow and survive during the early stages. Mainly dedicated to information technology, life science may appear to be the next hot spot for incubators. Are there stabilized good practices？ Are the business models in information technology and in life science comparable when it goes to start-ups＇ incubation？ Leveraging our experience as practitioner in this field and using an inductive methodology, this paper tends to propose simple principles to help build robust incubators in life science, and to contribute to disseminate an entrepreneurial approach through an industry still dominated by blue chips.     

建工实验室培养箱的温度测量不确定度评定

介绍了建工实验室培养箱温度测量的依据、标准及方法,根据温度示值误差测量数学模型,就温度示值标准不确定度的评定作了研究,以期选择符合实验条件的培养箱,提高建工实验准确度。     

基于模糊PID算法的婴儿培养箱的研究

婴儿培养箱广泛的应用于临床医疗中,主要是为早产婴儿或发育不良的新生儿创造一个温湿度相适宜的理想舒适环境,尤其是它的温度一定要精确稳定。市场上的婴儿培养箱总是存在着预热时间长、波动大的问题。鉴于此,本文基于模糊PID算法设计出了一种恒温婴儿培养箱,通过单片机实现其整个控制过程。分别介绍了其硬件组成及软件结构。该方法与采用传统的PID算法相比具有响应速度快、超调量小、鲁棒性强、精度高的优点。     

A model for selecting appropriate technology for incubator-university collaboration by considering the technology transfer mechanism

A technology incubator provides an important support for a technology transfer mechanism. A technology incubator bridges the incubatees to the technology provider. In our research, we propose a technology selection model for the incubatees. Incubator managers, as decision-makers, attempt to evaluate new technology for the incubatees by comparing its profit with that of the old or established technology. The technology is proposed by a technology provider, which in this case is a university. In the technology selection activity, the distance between the technology level of incubatees and transferred technology should be considered. Unfortunately, there has been no effort to formulate a technology selection model in the technology incubator that considers the technology distance and is linked to the incubatees’ profit as financial performance. We examine the impact of the technological-level and technology assimilation rate in the technology selection process in the technology incubator. We analyse the external factor of customer acceptance of new technology with a probabilistic value and technology obsolescence. Furthermore, we introduce a profit-sharing scheme to share the profit of the incubatees with the university as a technology provider. Utilising a profit-sharing scheme means sharing the risk between incubatees and the university.     

关于摇床的在线监测电路设计

生物摇床是一种实验室常见的微生物、细菌与细胞培养仪器。传统摇床仅能为被培养物质提供良好的培养环境,却无法获知其实时生长状况。为此,文中在浊度法的基础上设计了一种在线吸光度检测电路。该电路由LED控制电路、光电转换电路、放大电路与A/D采样电路4个模块组成,引入该电路系统的摇床能在生物培养的同时实现实时生物浓度检测。通过搭建相关实验平台,对该电路检测的准确性及稳定性做了系统验证。实验结果表明,设计的培养监测电路的吸光度检测误差控制在3%以内,能准确地反应出当前被培养物质的吸光度值,即该电路能实现生物摇床的在线监测培养。     

Influence of temperature on growth of Legionella pneumophila biofilm determined by precise temperature gradient incubator

Bacterial growth is influenced by several different culture conditions. Temperature is one of an essential component which regulates bacterial growth and their morphology. The influence of temperature on the length of bacteria was investigated in broth and on agar in a temperature range from 30.0 degrees C to 47.0 degrees C in 0.5 degrees C steps using a newly developed temperature gradient incubator. The incubator is able to reach a set temperature within 2 h and maintain temperature as accurate as +/-0.1 degrees C of the set temperature. Three Legionella pneumophila serotype 1 strains were incubated for 48 h in BCYE-alpha agar at various temperatures ranging from 30.0 degrees C to 48.0 degrees C and length of bacteria grown at each temperature was microscopically measured. Ability of bacteria to multiply at a given temperature was also determined. L. pneumophila serotype 1 strains ATCC 33152, a clinical isolate Okinawa 02-001 were going to elongate to longer than 100 mum when cultured higher than at 39.5 degrees C and at 41.5 degrees C, respectively. Each strain was unable to multiply when cultured higher than at 44.2 degrees C (ATCC 33152) or at 44.0 degrees C (Okinawa 02-001). Those data would provide insights for establishing regulations in terms of maintaining hot water temperature in a facility where a circulating hot water supply-system is available and contamination with Legionella spp. is likely to happen.     

Quantitative evaluation of bone resorption activity of osteoclast‐like cells by measuring calcium phosphate resorbing area using incubator‐facilitated and video‐enhanced microscopy

Quantitative evaluation of the ability of bone resorption activity in live osteoclast‐like cells (OCLs) has not yet been reported on. In this study, we observed the sequential morphological change of OCLs and measured the resorbing calcium phosphate (CP) area made by OCLs alone and with the addition of elcatonin utilizing incubator facilitated video‐enhanced microscopy. OCLs, which were obtained from a coculture of ddy‐mouse osteoblastic cells and bone marrow cells, were cultured on CP‐coated quartz cover slips. The CP‐free area increased constantly in the OCLs alone, whereas it did not increase after the addition of elcatonin. This study showed that analysis of the resorbed areas under the OCL body using this method enables the sequential quantitative evaluation of the bone resorption activity and the effect of several therapeutic agents on bone resorption in vitro. Microsc. Res. Tech, 2009. © 2008 Wiley‐Liss, Inc.     

从两个设计实例谈科技孵化楼的适宜性表达

建筑创作是一个多因素综合求解的过程。科技孵化楼作为一种研发、办公性质的建筑,需要统筹考虑环境、功能、文化等因素并寻求适宜的表达方式。文章结合两个科技孵化楼的设计实践,通过对设计问题的解答、设计过程的剖析,阐述了科技孵化楼的适宜性表达方式。     

基于无线数据传输的婴儿培养箱检测仪的设计

本文介绍了一种基于无线数据传输技术的婴儿培养箱检测仪的设计,该检测仪测温系统选用PT100铂金属温度传感器,测温精度为0.01℃。无线数据传输模块采用nRF905,测温探头配备检测支架,可以方便快捷地调整传感器布置点,检测完全自动化。开发软件用采用美国NI公司的LabVIEW2011可视化开发系统,人机交流界面友好。     

气相色谱仪柱温箱升温程序的调试方法

目的探究调试气相色谱仪柱温箱升温程序方法。方法比较分析柱温箱升温程序调试过程中柱流速、升温速率、不同温度下的保持时间等调试步骤对分离色谱峰的影响,确定调试步骤的前后顺序及调试方法。结果调试柱温箱升温程序后,在丁体六六六和氧化氯丹中间的干扰峰,出峰于丁体六六六和氧化氯丹后面,完全分离出来,减少了干扰峰对结果的影响。结论该方法可以更快速、有效的调试柱温箱升温程序,分离干扰峰,适合气相色谱仪柱温箱升温程序的调试。