The Influence of Nano-apatite on c-myc and p53 Gene in the Hepatocellular Carcinoma

The influence mechanism of the nano-apatite on the human hepatocellular carcinoma in vitro was investigated. Using the homogeneous precipitation method, the nano-apatite was synthesized at room temperature, and it was characterized with transmission electron microscopy (TEM) and the Zataplus. The influence on the expression of the c-myc and p53 gene in the human hepatocellalar carcinoma cell lines were tested with the TEM and hybridization in situ. The TEM and the Zataplus analyses show that the nano-apatite is distributed homogenously in size and needle-shaped sizes, which ranges from 67.5 nm to 88.3 nm. It is found that the nanoapatitet increases the volume of the human hepatocellalar carcinoma cells, makes extensive cytoplasmic vacuolization, the mitochondria swelling, chromatin in nucleus dispersed partially and condensed around the nuclear membranes. The interspace in nuclear membranes were separated and even the cytoplasm dissolved. It is also found that the expression of the c-myc gene is inhibited, but the p53 /s enhanced. The experimental results demonstrate that the nano-apatite enables the oneosis of the human hepatocellular carcinoma cells by down-regulation of the expression of the c-myc and up-regulation of the expression of the p53 in vitro.     

Preparation of Perovskite-Type Oxides La1-x Srx Fe1-y Coy O3 Using EDTA Sol-Gel Method

Two series of perovskite-type oxides with composition La1-xSrxFeO3 (x≤0.8)and La1-xSrxFe1-yCoyO3( x = 0.2；y = 0.2, 0.4 ) powder productions were synthesized by EDTA complexing sol-gel method. The products were characterized by XRD, TEM, SEM, BET method (N2 adsorption)and laser granularity analysis for different synthesis conditions to obtain the optimum conditions for the preparation process. Single-phased, uniform perovskite-type oxides with small particle size were obtained by EDTA sol-gel process with high stability and repeatability,and the process temperature is much lower than that of solid state reaction method.     

万吨级高吸水树脂光催化梯次引发聚合反应器工艺包开发及控制优化研究

以丙烯酸及盐溶液聚合和光催化梯次辐射能传递自由基聚合相结合的工艺流程,从工业化聚合装置的角度对丙烯酸系溶液聚合光催化反应器进行了剖析,研究了丙烯酸及盐溶液聚合复杂体系的热力学物性计算模型及其参数确定方法;从丙烯酸及盐聚合反应过程的光催化机理和反应动力学入手,基于梯次光催化反应动力学对万吨级工业化聚合装置全流程动态建模,进行反应器操作条件、动态特性、物态物性等分析,工业示范装置流程优化运行及工业化实验装置的带料调试。对聚合反应器体系进行项目开发评价,对指导项目开发具有重要的实践和指导意义。     

Photochemical synthesis and characterization of novel narrow size distribution core-shell magnetic nanogels

Modified magnetic nanoparticles have gained considerable attention because of their great potential applications in biomedical fields, such as protein and enzyme immobilization, bioseparation, immunoassays and biosensor etc. In recent years, great efforts have been made in developing targeted drug carriers by use of magnetic nanogels.     

诺兰达炉渣综合利用研究(下)

诺砂中含有70％～80％的铁橄榄石矿物成分，是自然界中罕见的矿产资源。诺砂中的非晶质玻璃相、初生态铁橄榄石及水解反应中生成的Fe(OH)3与Fe(OH)2凝胶体，它们在水泥混凝土制品中有“活化”“密填”及“胶凝”3种增强作用。通过大量试验数据及生产实践证实上述结论的可靠性。若能将诺砂有效利用，定能获得丰厚的经济效益。     

用含氯试剂改性三元乙丙橡胶

俄罗斯科研人员十分关注这一加工工艺一文中用大量的科研数据，用热机械化学方法改性橡胶，介绍了该工艺的技术原理，在热机械化学改性过程中，通过三元乙丙橡胶与舍氯试剂相互作用．制得舍氯三元乙丙橡胶，在热机械作用下，三元乙丙橡胶的分子量开始增加，然后再下降，凝胶体含量发生类似的变化在用舍氯试剂对三元乙丙橡胶进行热机械化学改性的过程中，当采用改性剂M，时三元乙丙橡胶的反应能力高于采用改性剂M!时的反应能力，改性产品中舍氯量接近，但结构不同，在三元乙丙橡胶大分子结构中添加氯会使混炼胶的硫化速率加快。     

海藻酸钠凝胶特性的研究

研究了海藻酸钠的浓度、氯化钙浓度、凝胶温度及增塑剂对海藻酸钠凝胶强度、持水性、弹性以及外观特性的影响,采用L9(34)正交实验优选出最佳凝胶条件.实验结果表明:海藻酸钠凝胶特性与凝胶体内的钠钙比率有密切关系;凝胶的温度及增塑剂对凝胶特性也有影响.通过正交实验得到最优实验方案:3%的海藻酸钠溶液与5%的氯化钙在60℃下胶化成形,所形成的凝胶性能最好.     

褐藻酸钙凝胶制备法

褐藻酸钙凝胶(以下称Aeg-Ca凝胶)在食品上的应用,目前还是一个尚未完全解决的问题,这是因为Aeg-Ca凝胶有以下的特点:难以从褐藻酸钠(以下称Aeg-Na)水溶液中直接方便地、大量地生产:均质成型较困难;极易受各种具有螯合作用的螯合剂的影响;制品口感不如琼胶。之类凝胶制品等。但也由于Aeg-Ca凝胶具有较好的抗拉、抗压和耐热性,所以又一直吸引着食品业界的研究人员继续努力探讨其有效的利用途径。本文将简要介绍Aeg-Ca凝胶的制备法及几个实例。     

物理作用力对k—卡拉胶凝胶体质构特性影响的研究

研究了不同的盐类和有机试剂对κ 卡拉胶凝胶体质构特性的影响。结果表明 ,NaCl和NaSCN对凝胶特性的影响显著不同 ,随着NaCl浓度的增加 ,卡拉胶的硬度和破裂强度逐渐增加但凝胶体的其他特性即下降 ;NaSCN在低浓度时 (≤ 0 1mol/L)显著增加了凝胶体的硬度和破裂强度 ,而其他特性也下降。随着NaSCN浓度的增加 (>0 1mol/L) ,凝胶体的所有特性都下降 ;添加 0 1mol/L的KCl和KSCN极大的提高了凝胶体的质构特性。KCl和KSCN对凝胶体质构特性的影响趋势相似 ,但KCl的影响更大。氢键也是κ 卡拉胶形成凝胶的主要作用力     

溶凝胶体开辟进入主流的道路

溶凝胶 ,一种用来生产初级氧化物陶瓷玻璃的低温工艺 ,正逐步从实验室走向市场。预期用溶凝胶生产膜层、透镜和波导的光学工业在 2 0 0 3年将占溶凝胶体市场的 40 % ,据商务通信公司的估计。其时全球的溶凝胶销售量将达 3.4亿美元。虽然溶凝胶研究在过去十年有极大的增加 ,技术和经济上的壁垒使其商业化步伐很慢。虽然如此 ,几种光学产品已上市销售 ,包括梯度折射率透镜、用于阴极射线管的相衬增强膜层、一氧化碳传感器和用于窗口、反射镜和激光器的防反 (增透 )膜层 (见表 1 )。从化学品到玻璃溶凝胶能用碱氧化物或以水为基础的工艺生成。…