The Grand Work of Fiction: The Detail as Narrative

A practising architect and Professor at the University of Virginia School of Architecture, Edward Ford is the leading expert on the architectural detail and the author of three seminal books on the subject. Here Ford explains that, though the decision ‘to abstract or to articulate’ architecture ‘may be largely subconscious’, it is never ‘arbitrary’. For ‘in the well-designed building, it is done in the service of the creation of a larger narrative, a unity of vision’.     

Symbolic and numeric computations of the Barnes function

This paper discusses some theoretical aspects and algorithms for high-precision computation of the Barnes gamma function.     

关于32维Barnes-Wal格的有效译码算法

本文给出了３２维Ｂａｒｎｅｓ－Ｗａｌ格的一个有效的译码算法，该算法将这个格的译码问题转化为在ＲＭ（２，５）＝（３２，１６，８）码的修正赋权格子图上求最短路径的问题，该算法在最坏情况下的译码时间复杂性为２２７８３次二元运算，小于Ｆｏｒｎｅｙ给出算法的最坏时间复杂性。此外，该算法结构简单易于实现     

Alfred Stieglitz and New Yark Dada

Abstract

In February of 1921 the photographer and entrepreneur Alfred Stieglitz mounted the fIrst public exhibition of his work since the closing of his pioneering art gallery, ‘291’, nearly four years earlier.1 An exhibition of 146 of Stieglitz's photographs was held at the Anderson Galleries in New York during February of 1921. This show was instrumental in helping Stieglitz ultimately to reassert his prominence in the New York art world and re-establish his status as an important American artist. Curiously, however, the manner in which Stieglitz and his associates chose to promote the photographer was somewhat unusual. They repeatedly described the camera as an extension of Stieglitz's own body, and his photographs as an extension of his spirit. As a result, they claimed that Stieglitz had achieved a profound physical and spiritual union both with his machinery and with the subjects he photographed.     

An n-3 fatty acid deficiency impairs rat spatial learning in the Barnes maze.

In this study, the authors demonstrate that rats with n-3 fatty acid deficiency display spatial learning deficits in the Barnes circular maze. Dams were deprived of n-3 fatty acids during pregnancy and lactation, and their offspring were weaned to the same deficient diet. There was a 58% loss of brain docosahexaenoic acid (DHA) in the n-3 fatty acid-deficient rats in comparison to n-3 fatty acid-adequate rats. At 8 weeks of age, deficient rats demonstrated moderate impairment in Barnes maze performance compared with the n-3 fatty acid-adequate rats during the initial training. In the reversal learning task, the n-3 fatty acid-deficient rats showed a profound deficit in performance: They required more time to find a new position of the escape tunnel, which was accompanied by a higher number of errors and perseverations. The n-3 fatty acid-deficient rats had reduced tissue levels of dopamine in the ventral striatum and enhanced levels of the metabolite 3,4-dihydroxyphenylacetic acid in frontal cortex and hypothalamus. In summary, this study demonstrates that rats with low brain DHA have a deficit in spatial reversal learning that could be related to changes in dopamine transmission in critical brain circuits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

深井阳极地床设计中沿深度方向土壤电阻率的测试与分析

指出目前深井阳极地床设计沿深度方向土壤电阻率测试中存在的问题,主要体现在缺少对测试结果的进一步分析,从而使得测试结果对工程实践指导意义不大。介绍了巴恩斯分析法在沿深度方向土壤电阻率测试中的应用,结合工程实例对该方法进行分析和验证,得出了具有原理简单,计算简便及满足工程精度要求等结论。提出在应用时应注意的问题,特别是数据拟合方法在数据处理时是不适用的。     

受地理边界限制的Barnes插值

以地面近实时气象要素分析图Web服务为目标,提出一种基于地理边界的Barnes插值方案,实现地面气象观测数据对格点场的插值。首先使用数值微分法和种子填充法得出地理边界剪裁矩阵,进而从Barnes插值算法中分离出插值权值常量,最后将其用于格点插值分析工作。方案不仅可以改善图形分析品质,而且去除了GIS出图过程中的图形剪裁步骤,明显缩短图形分析产品所花费的时间。该技术已用于中国天气网、四川气象网、成都公共气象服务网、四川农村信息网等多个公共服务网站的二维、三维地面近实时气象要素图形分析服务。     

真的存在科学革命吗? --试论巴恩斯对库恩的诘问

库恩把科学分为常规科学和科学革命两个交替的阶段。然而巴恩斯对此提出了不同的意见，他认为科学革命没有存在的必要。因为如同科学革命时期一样，在常规科学时期：意义的变化、技术的变化、新的解题方式的发明和新的判断标准都会出现。     

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice

Alzheimer’s disease (AD) is a chronic neurodegenerative disorder. This study was designed to investigate the effects of cyclopentanone derivative i.e., 2-(hydroxyl-(3-nitrophenyl)methyl)cyclopentanone (3NCP) on behavior, amyloid β (Aβ) plaque deposition, and βAPP cleaving enzyme-1 (BACE-1) expression in the 5xFAD mouse brain. In this study, computational studies were conducted to predict the binding mode of the 3NCP with target sites of the β-secretase. In vivo studies were performed on the 5xFAD mice model of AD using different behavioral test models like light/dark box, elevated plus maze (EPM), and the Barnes maze tests for the assessment of anxiety, spatial learning and memory. The thioflavin-S staining, immunohistochemistry (IHC), and RT-PCR studies were carried out to find the effect of the 3NCP on the β-amyloid plaques formation and BACE-1 expression. The results of the computational studies showed that the 3NCP has excellent binding affinities for beta-secretase. The light/dark box study depicted that the 3NCP does not cause anxiety. The 3NCP treatment effects in the EPM and Barnes maze tests showed a significant effect on learning and memory. Furthermore, the results of the thioflavin staining and IHC revealed that the 3NCP significantly reduced the formation of the beta-amyloid plaques in brain tissues. Moreover, the RT-PCR study showed that 3NCP significantly reduced the BACE-1 expression in the brain. Conclusively, the results of the current study demonstrate that the 3NCP may be a potential candidate for AD treatment in the future.