Piperacillin/tazobactam‐induced neurotoxicity in a hemodialysis patient: A case report

Antibiotics are potentially a cause of neurotoxicity in dialysis patients, the most common are the beta‐lactams as ceftazidime and cefepime, and few cases have been reported after piperacillin/tazobactam use. This report presents a case of a hypertensive and diabetic 67‐year‐old woman in regular hemodialysis, which previously had a stroke. She was hospitalized presenting pneumonia, which was initially treated with cefepime. Two days after treatment, she presented dysarthria, left hemiparesis, ataxia, and IX and X cranial nerves paresis. Computed tomography showed no acute lesions and cefepime neurotoxicity was hypothesized, and the antibiotic was replaced by piperacillin/tazobactam. The neurologic signs disappeared; however, 4 days after with piperacillin/tazobactam treatment, the neurological manifestations returned. A new computed tomography showed no new lesions, and the second antibiotic regimen withdrawn. After two hemodialysis sessions, the patient completely recovered from neurological manifestations. The patient presented sequentially neurotoxicity caused by two beta‐lactams antibiotics. This report meant to alert clinicians that these antibiotics have dangerous neurological effects in chronic kidney disease patients.     

Inhibition of Spore Germination of Phakopsora Pachyrhizi Using Crude Extracts of Amaranthus Spinosus

The effectiveness of methanolic and n-hexane crude extracts of Amaranthus spinosus to inhibit the spore germination of Phakopsora pachyrhizi, a causal agent of soybean rust disease was studied. Both methanolic and n-hexane crude extracts inhibited spore germination at concentrations of 0.1% to 5.0%. Methanolic extract of the roots at a concentration of 2.5% inhibited 55% of spore germination, and this result was similar when higher concentration at 5% of methanolic and n-hexane extracts of the flowers was used. The presence of alkaloids, flavonoids, tannins, saponins, and terpenoids in the extract may be responsible for the inhibition. The extract was potential to be utilized as a botanical fungicide.     

积极降压对脑小血管病防治策略的影响

2017年,美国心脏病学会和美国心脏协会提出将高血压诊断标准降为130/80 mm Hg (1 mm Hg=0. 133 kPa),这与其他指南有所不同。降压治疗的核心目标在于靶器官的保护,近年来降压治疗与脑小血管病预防的相关问题日益受到临床重视。目前研究结果表明,降压治疗对腔隙性卒中患者的二级预防以及白质病变进展的预防可能有一定积极意义,但确切的降压目标值并未确定。血压与临床结局可能呈现J型关系,血压过低或过高可能均有害,而取得最大获益的降压目标有待进一步探索。     

An evaluation of biological and abiotic controls for grapevine powdery mildew. 2. Vineyard trials

Grapevine powdery mildew ( Erysiphe necator) affects grape yield and fruit quality worldwide. Managers of conventional vineyards rely mainly on synthetic fungicides and sulfur to control powdery mildew, while in organic vineyards sulfur is the main control agent, often in rotation with canola-based oils, bicarbonates and biological control agents. The efficacy of those materials has not been evaluated critically under field conditions in Australia. Accordingly, a range of materials showing most promise in previous greenhouse trials (Crisp et al. 2006 Australian Journal of Grape and Wine Research 12 , pp. 192–202) were assessed via field trials in commercial vineyards. Applications of either milk or whey (alone, or mixed with a canola oil-based product), as well as applications of potassium bicarbonate (commercial formulation), all reduced the severity of powdery mildew compared with untreated vines. Eight applications of a 1:10 dilution of milk, 45 g/L whey powder or programs comprising rotations of potassium bicarbonate plus oil and whey, applied at 10–14 day intervals, reduced the severity of powdery mildew to levels not significantly different from that on vines sprayed with sulfur (wettable powder, 3–6 g/L). However, the relative control of powdery mildew by the test materials in field trials was dependent on the susceptibility of the grapevine cultivar and the extent of spray coverage achieved. In vineyards where highly susceptible cultivars were planted, and spray coverage was compromised, the resultant control of powdery mildew was reduced; and sometimes to commercially unacceptable levels.     

The five elements and chinese-american mortality.

D. P. Phillips, T. E. Ruth, and L. M. Wagner (1993) reported that 1969-1990 California mortality data show that Chinese Americans are particularly vulnerable to diseases that Chinese astrology and traditional Chinese medicine associate with their birth years. For example, because fire is associated with the heart, a Chinese person born in a fire year (such as 1937) is more likely to die of heart disease than is a Chinese person born in a nonfire year. However, many diseases were excluded from this study, some diseases that were included have ambiguous links to birth years, and the statistical tests were indirect. A more complete statistical analysis and independent California mortality data for the years 1960-1968 and 1991-2002 did not replicate the original results. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

牙鲆淋巴囊肿病的PCR诊断方法研究

以中国养殖牙鲆 (Paralichthysolivaceus)淋巴囊肿病毒 (Lymphocystisdiseasevirus,LCDVcn)主要衣壳蛋白 (majorcapsidprotein ,MCP)基因的中间保守序列为目标基因 ,设计了一对特异性引物。该引物可扩增出 172bp的病毒DNA片段 ,其最小DNA检出量为 0 0 183ng。用PCR法从人工感染淋巴囊肿病毒 3天的牙鲆血、鳃、肝、脾、肠、胃及自然发病牙鲆的肿瘤中 ,分别检测到了LCDV的存在。本实验结果证明 ,PCR法对于早期检测LCDV是十分有效的。     

陕西南部路基病害分布特征及主要控制因素探讨

在统计分析的基础上,归纳总结了陕西南部各类路基病害的分布特征,并从自然因素和人为因素两个方面分析了各类路基病害发生的主要控制因素。     

Working memory in mild Alzheimer's disease and early Parkinson's disease.

Alzheimer's disease (AD) and Parkinson's disease (PD) impair working memory (WM). It is unclear, however, whether the deficits seen early in the course of these diseases are similar. To address this issue, the authors compared the performance of 22 patients with mild AD, 20 patients with early PD and without dementia, and 112 control participants on tests of inhibition, short-term memory, and 2 commonly administered tests of WM. The results suggest that although mild AD and early PD both impair WM, the deficits may be related to the interruption of different processes that contribute to WM performance. Early PD disrupted inhibitory processes, whereas mild AD did not. The WM deficits seen in patients with AD may be secondary to deficits in other cognitive capacities, including semantic memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Risk Factors for Course of Posttraumatic Stress Disorder Among Vietnam Veterans: A 14-Year Follow-Up of American Legionnaires.

Risk factors affecting the course of posttraumatic stress disorder (PTSD) are poorly understood. As part of a larger study on characterizing exposure to herbicides in Vietnam, the authors investigated this issue in a random sample of 1,377 American Legionnaires who had served in Southeast Asia during the Vietnam War and were followed over a 14-year period. High combat exposure, perceived negative community attitudes at homecoming, minority race, depression symptoms at Time 1, and more anger at Time 1 predicted a more chronic course. Community involvement at Time 1 was protective and associated with decreased risk at Time 2. Discomfort in disclosing Vietnam experiences was associated with an increased risk for developing PTSD but did not predict its course. Combat exposure predicted PTSD course more strongly than any other risk factor. Findings suggest recovery from PTSD is significantly influenced by perceived social support. (PsycINFO Database Record (c) 2010 APA, all rights reserved)