药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

青年医学工作者科普能力培养新模式

为了培养青年医师运用医学科普语言传播医学知识的能力，向社会提供更优质、可及的健康知识，改善医患关系，促进社会和谐；同时出于向社区、媒体推送一批优秀青年医学科普人才的考虑，本文在总结北京协和医院培养青年医务人员医学科普能力经验的基础上，尝试构建一套适合大型公立医院（尤其是教学医院）培养青年医务人员医学科普能力的新模式——“科普训练营”。本文旨在系统介绍该模式的产生背景、实践经验及初期效果，阐释实施后的重要意义，及实施过程中的挑战与应对策略。     

A semantic modeling approach for image retrieval by content

We introduce a semantic data model to capture the hierarchical, spatial, temporal, and evolutionary semantics of images in pictorial databases. This model mimics the user's conceptual view of the image content, providing the framework and guidelines for preprocessing to extract image features. Based on the model constructs, a spatial evolutionary query language (SEQL), which provides direct image object manipulation capabilities, is presented. With semantic information captured in the model, spatial evolutionary queries are answered efficiently. Using an object-oriented platform, a prototype medical-image management system was implemented at UCLA to demonstrate the feasibility of the proposed approach.     

Alpha induced reactions on Sn: An experimental study of excitation functions and possible production pathways

In the frame of a systematic study of light ion induced threshold reactions on natural tin (Sn) excitation functions for alpha particles induced reactions are presented in a 12–38 MeV energy domain. Using a stacked foil activation method the following radioisotopes were identified: ¹¹⁶Te, ¹¹⁷Te, ¹¹⁸Te, ¹¹⁹Te, ¹²¹Te, ¹²³Te, ¹¹⁷Sb, ¹¹⁸Sb, ¹²⁰Sb, ¹²²Sb, ¹²⁴Sb, ¹²⁶Sb, ¹¹⁷Sn, ¹¹¹In. The experimental cross sections for these isotopes are presented for the first time in this energy range and a direct comparison with values calculated with the ALICE-IPPE code is discussed. Possible use of these data for production of some isotopes relevant in nuclear medicine is suggested.     

Mass customization of medical devices and implants: state of the art and future directions

The medical field is one in which the need for customization can be clear cut, as providing tailored devices and implants for unique physiologies can provide for a better overall treatment than the use of 'off the shelf' devices and implants. Customization in the production of medical products can be roughly divided into consideration of medical devices, and of implantable parts or systems. The present paper outlines the current state of the art in both of these areas, presents details of projects that are ongoing at the University of Leeds and outlines future research directions.     

宝鸡市医用诊断X线照射频度调查

本文报道从1984年6月1日至1985年5月31日对宝鸡市五县(区)医用诊断 X 线照射频度的调查结果。结果表明,胸透和群检胸透医照率最高,占医疗照射总人次数的68.7%,门诊医照率为70.8人次/千人·年,人群受照率为344。5人次/千人·年。按年龄比较,青壮年组医照率最高,占医照总人次数的57.2%。按性别比较,男性多于女性。     

启发式教学的Visual FoxPro课堂实践

《VisualFoxPro程序设计》是医学院校普遍开设的计算机课程,结合医学院校中《VisualFox—Pro程序设计》课程特点,提出在课堂教学过程巧用启发式教学。并结合教学实例说明启发式教学能充分调动学生积极性,使学生真正参与课堂．从而取得好的教学效果。     

Quadratic polynomial guided fuzzy C-means and dual attention mechanism for medical image segmentation

Medical image segmentation is the most complex and important task in the field of medical image processing and analysis, as it is linked to disease diagnosis accuracy. However, due to the medical image's high complexity and noise, segmentation performance is limited. We propose a novel quadratic polynomial guided fuzzy C-means and dual attention mechanism composite network model architecture to address the aforementioned issues (QPFC-DA). It has mechanisms for channel and spatial edge attention, which guide the content and edge segmentation branches, respectively. The bi-directional long short-term memory network was added after the two content segmentation branches to better integrate multi-scale features and prevent the loss of important features. Furthermore, the fuzzy C-means algorithm guided by the quadratic polynomial can better distinguish the image's weak edge regions and has a degree of noise resistance, resulting in a membership matrix with less ambiguity and a more reliable segmentation result. We also conducted comparison and ablation experiments on three medical data sets. The experimental results show that this method is superior to several other well-known methods.     

零库存流程管理在医院成本核算中的应用

随着各类医用耗材、消毒品数量和种类的增加,医院物资管理在医院运营中的作用越来越显著。在提倡以患者为中心,提高患者满意度的宗旨下,与患者直接接触的HIS、LIS、PACS、CIS等医疗系统发展十分迅速,而医院内部使用的物资管理系统却比较落后。针对在医院实际医用物资管理中,时常发生医疗物资积压和医疗耗材缺货导致医疗时机延误等问题,对现有物资管理系统中的不足进行分析,并提出一种以零库存管理为基础的新工作流程,以解决现有的一些问题,并在继续深入探讨和研究。     

Evaluation of a haptics-based virtual reality temporal bone simulator for anatomy and surgery training

Introduction

Virtual reality simulation training may improve knowledge of anatomy and surgical skills. We evaluated a 3-dimensional, haptic, virtual reality temporal bone simulator for dissection training.

Methods

The subjects were 7 otolaryngology residents (3 training sessions each) and 7 medical students (1 training session each). The virtual reality temporal bone simulation station included a computer with software that was linked to a force-feedback hand stylus, and the system recorded performance and collisions with vital anatomic structures. Subjects performed virtual reality dissections and completed questionnaires after the training sessions.

Results

Residents and students had favorable responses to most questions of the technology acceptance model (TAM) questionnaire. The average TAM scores were above neutral for residents and medical students in all domains, and the average TAM score for residents was significantly higher for the usefulness domain and lower for the playful domain than students. The average satisfaction questionnaire for residents showed that residents had greater overall satisfaction with cadaver temporal bone dissection training than training with the virtual reality simulator or plastic temporal bone. For medical students, the average comprehension score was significantly increased from before to after training for all anatomic structures. Medical students had significantly more collisions with the dura than residents. The residents had similar mean performance scores after the first and third training sessions for all dissection procedures.

Discussion

The virtual reality temporal bone simulator provided satisfactory training for otolaryngology residents and medical students.