二甲氨基丙基丙烯酰胺改性含氢硅油的合成

以氯铂酸-异丙醇为催化剂,二甲氨基丙基丙烯酰胺与含氢硅油为原料,在甲苯为溶剂的条件下,通过硅氢加成反应,将二甲氨基丙基丙烯酰胺接枝到含氢硅油侧链,合成了氨基改性硅油,其中甲苯的质量为含氢硅油与二甲氨基丙基丙烯酰胺质量总和的1.5倍,阻聚剂0.5%(对单体质量),n(含氢硅油)∶n(二甲氨基丙基丙烯酰胺)=1∶1.1,催化剂用量为反应物质量的50×10-6,120℃进行硅氢加成反应.并对其进行了红外光谱测试,结果表明:氨基基团已成功地引入到含氢硅油侧链上,合成了氨基改性硅油.     

Preparation,characterization, and in vitro bioactivity of magnetic co-polymer [N,N-dimethylaminopropylacrylamide-co-1-allylimidazole] as a new nanocarrier for delivery of cefotaxime

In this research, new magnetic nanoparticles (MNPs) conjugated radical co-polymerization with N, N-dimethylaminopropylacrylamide (N, N-DMAPAAm) as a thermosensitive monomer and 1-allylimidazole (AI) as a cross-linker agent was prepared as a magnetic nanocomposite (MNC). The synthesized MNC were characterized by Fourier transform infrared spectroscopy, Elemental analysis (CHN), Field emission scanning electron microscopy, Vibrating Sample Magnetometer, and Thermo Gravimetric Analysis. Cefotaxime was selected as a model drug and was loaded into the synthesized polymer. The main factors of adsorption process such as pH, contact time, temperature, and eluent were evaluated and optimized. The mechanism of cefotaxime adsorption is explained by Langmuir isotherm. Also, in vitro cefotaxime delivery in the simulated gastric and intestinal fluids was investigated. The drug release profile revealed that about 30.35% of the adsorbed cefotaxime was released in the first 30 min. at pH =1.2 (simulated gastric fluid) and 62.65% was released during 15 h at pH =7.4 (simulated intestinal fluid).     

丙烯酰胺丙基二甲基胺

以丙烯酰胺和N,N-二甲基丙胺为原料,吩噻嗪为阻聚剂,制备了丙烯酰胺丙基二甲基胺。最佳反应条件是反应温度165℃,反应时间6h,阻聚剂的加入量为0·5%。得到的产品质量分数为98·28%,收率达86·2%。