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The problem of operating freeze drying of pharmaceutical products in vials placed in trays of a freeze dryer to remove free water (in frozen state) at a minimum time was formulated as an optimal control problem. Two different types of freeze dryer designs were considered. In type I freeze dryer design, upper and lower plate temperatures were controlled together, while in type II freeze dryer design, upper and lower plate temperatures were controlled independently. The heat input to the material being dried and the drying chamber pressure were considered as control variables. Constraints were placed on the system state variables by the melting and scorch temperatures during primary drying stage. Necessary conditions of optimality for the primary drying stage of freeze drying process in vials are derived and presented. Furthermore, an approach for constructing the optimal control policies that would minimize the drying time for the primary drying stage was given. In order to analyze optimal control policy for the primary drying stage of the freeze-drying process in vials, a rigorous multi-dimensional unsteady state mathematical model was used. The theoretical approach presented in this work was applied in the freeze drying of skim milk. Significant reductions in the drying times of primary drying stage of freeze drying process in vials were obtained, as compared to the drying times obtained from conventional operational policies. 相似文献
3.
中厚板轧制边部不均匀变形机理的探讨 总被引:1,自引:0,他引:1
通过分析宽中厚板轧制过程中的边部不均匀变形,探讨了其影响因素及大宽度板“切边纵裂”的产生原因,提出了解决问题的具体办法。 相似文献
4.
针对中小型企业销售管理的现状,利用J2EE架构技术设计了面向中小型企业的销售管理信息系统,该系统具有良好的跨平台性和可移植性,并且经过测试运行,达到了预期的效果。 相似文献
5.
跳出传统的设计思路,提出装多件内装物的瓦楞纸箱尺寸优化设计方法,建立优化设计模型,编写程序用于生产,节省纸用量,降低成本。 相似文献
6.
This investigation proposes a fixed collision rate (FCR) back-off algorithm for wireless networks. The proposed scheme takes advantage of the central unit (CU) in a wireless network to broadcast a common back-off window size to all the users, significantly alleviating the unfairness of bandwidth utilization in conventional binary exponential back-off (BEB) algorithms. It is shown that, when maximum throughput is achieved, collision rate is almost a constant for any traffic load. In the operation of the FCR, the CU dynamically adjusts the back-off window size to keep the collision rate at a constant level for maximum throughput. Simulation results demonstrate that the unfairness of bandwidth utilization in the BEB is significantly lessened and the throughput can be maintained at e-1≈0.368 when the number of users approaches infinity. The capture effect even further improves system performance. 相似文献
7.
Optimal synthesis of tunable elastic wave-guides 总被引:1,自引:0,他引:1
Anton Evgrafov Cory J. Rupp 《Computer Methods in Applied Mechanics and Engineering》2008,198(2):292-301
Topology optimization, or control in the coefficients of partial differential equations, has been successfully utilized for designing wave-guides with precisely tailored functionalities. For many applications it would be desirable to have the possibility of drastically altering the wave-guiding properties of a device “on the fly,” in a controllable manner as an influence of some external input. This would enable wave-guides with highly non-linear input-output mappings, such as for example controllable wave switches.In this paper, we propose using finite elastic pre-straining for the purpose of tuning a wave-guide. In order to systematically formulate and solve the wave-guide synthesis problems we utilize mathematical programming methods in conjunction with topology optimization for parametrizing the design space. The resulting extremal problem is, from a practical point, equivalent to finding an optimal subdivision of a given control volume into two disjoint subsets occupied by two different materials, normally resulting in a highly heterogeneous elastic body with desired wave-guiding functionalities in the original and finitely deformed configurations.The proposed methodology is illustrated with numerical examples. 相似文献
8.
本文介绍了南钢中板厂将系统工程最优化技术中的随机服务系统理论和可靠性设计方法引入到电气设备的维护和管理工作中,并结合现场实际情况摸索出一套电气设备可靠性保障方法。 相似文献
9.
Gülü Insel Derin Orhon Peter A Vanrolleghem 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2003,78(4):437-445
Hydrolysis mechanism plays a dominant role in the delicate balance of electron donor/electron acceptor ratios in BNR and EBPR systems as an important carbon source. In this study, the surface‐saturation‐type hydrolysis kinetics was investigated based on respirometric measurements, within the context of the theoretical and the practical identifiability of mathematical models. The identifiable parameters of a selected model were derived from respirograms. In addition, the information from the experiments was evaluated on the basis of Optimal Experimental Design (OED) methodology for different initial conditions of the batch respirometric experiment. © 2003 Society of Chemical Industry 相似文献
10.
行激励级电路的设计是完全为行输出级服务的,它实质上是行输出级电路设计的一个重要而不可分割的组成部分。因此行激励级电路的设计,自然采用了从显象管偏转线圈和行输出管到激励变压器和行激励级的倒推设计法。 相似文献