钻井液振动筛叠层筛网透筛率的研究

从理论上详细论述了钻井液振动筛叠层筛网对固相颗粒分离的影响 ,首次提出用透筛率的概念定量地描述这一影响 ,并进行了实例计算。研究表明 ,当上下层筛网随机叠加时对透筛率的影响有以下几种情况 :(1)当上下层筛网开孔尺寸相除的余数为零 ,任意组合叠层筛网的透筛率分别为某一常数 ;(2 )上层筛网目数一定时 ,下层筛网目数越大 ,则透筛率越小 ;(3)上下层筛网的目数相差越小 ,透筛率越小 ;(4 )任意目数的上下层筛网随机叠加后 ,其透筛率仅在一个小范围内变化 ,因此任一叠层筛网有其固有的透筛率属性。     

水力自动翻板闸门的瞬心轨迹及其对稳定性的影响

分析了连杆滚轮式水力自动翻板闸门的运动轨迹，并由此得出闸门动、静坐标系间的转换关系．结合翻板闸门的运转机理，探讨了闸门在运行过程中的瞬心轨迹线及其对闸门稳定性的影响．结果表明，通过优化闸门结构可调整“瞬心”的位置，保证闸门运转的稳定性．     

绕扰流片分离流动的壁面压力测量

在风洞中用电子扫描阀进行测压实验，研究了底部间隙和锯齿高度对扰流片引起的壁面压力分布的影响。结果表明底部间隙在g／h≥1．0时对扰流片上游壁面压力分布曲线有较大影响，而对下游回流区压力分布曲线的影响主要在0≤g／h≤2．0的区域内；并且在g／^=0．2、1．0时，流动结构发生改变。另外，锯齿扰流片的当量面积与平板扰流片相等时，锯齿高度对下游底板压力分布特性的影响亦主要限于0≤x／h≤2．0的区域。     

Refining Genotypes and Phenotypes in KCNA2-Related Neurological Disorders

Pathogenic variants in KCNA2, encoding for the voltage-gated potassium channel K_v1.2, have been identified as the cause for an evolving spectrum of neurological disorders. Affected individuals show early-onset developmental and epileptic encephalopathy, intellectual disability, and movement disorders resulting from cerebellar dysfunction. In addition, individuals with a milder course of epilepsy, complicated hereditary spastic paraplegia, and episodic ataxia have been reported. By analyzing phenotypic, functional, and genetic data from published reports and novel cases, we refine and further delineate phenotypic as well as functional subgroups of KCNA2-associated disorders. Carriers of variants, leading to complex and mixed channel dysfunction that are associated with a gain- and loss-of-potassium conductance, more often show early developmental abnormalities and an earlier onset of epilepsy compared to individuals with variants resulting in loss- or gain-of-function. We describe seven additional individuals harboring three known and the novel KCNA2 variants p.(Pro407Ala) and p.(Tyr417Cys). The location of variants reported here highlights the importance of the proline(405)–valine(406)–proline(407) (PVP) motif in transmembrane domain S6 as a mutational hotspot. A novel case of self-limited infantile seizures suggests a continuous clinical spectrum of KCNA2-related disorders. Our study provides further insights into the clinical spectrum, genotype–phenotype correlation, variability, and predicted functional impact of KCNA2 variants.     

Melanin Distribution in Human Skin: Influence of Cytoskeletal,Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes

Melanin granules cluster within supra-nuclear caps in basal keratinocytes (KCs) of the human epidermis, where they protect KC genomic DNA against ultraviolet radiation (UVR) damage. While much is known about melanogenesis in melanocytes (MCs) and a moderate amount about melanin transfer from MC to KC, we know little about the fate of melanin once inside KCs. We recently reported that melanin fate in progenitor KCs is regulated by rare asymmetric organelle movement during mitosis. Here, we explore the role of actin, microtubules, and centrosome-associated machinery in distributing melanin within KCs. Short-term cultures of human skin explants were treated with cytochalasin-B and nocodazole to target actin filaments and microtubules, respectively. Treatment effects on melanin distribution were assessed by the Warthin–Starry stain, on centrosome-associated proteins by immunofluorescence microscopy, and on co-localisation with melanin granules by brightfield microscopy. Cytochalasin-B treatment disassembled supra-nuclear melanin caps, while nocodazole treatment moved melanin from the apical to basal KC domain. Centrosome and centriolar satellite-associated proteins showed a high degree of co-localisation with melanin. Thus, once melanin granules are transferred to KCs, their preferred apical distribution appears to be facilitated by coordinated movement of centrosomes and centriolar satellites. This mechanism may control melanin’s strategic position within UVR-exposed KCs.     

冲击式振动落砂机的动态响应与分叉

本文考虑一类振动落砂机简化力学模型的次谐运动、稳定性与分叉问题.数值工作表明该模型存在"跳跃"和多种分叉现象.     

液压卧倒闸坝在拦河坝工程中的应用

简述液压卧倒闸坝在江西省宜春市袁州区温汤镇防洪工程拦河坝中的应用。设计通过对多方案技术经济比选,推荐采用液压卧倒闸坝。可供类似工程参考。     

基于层次分析法的沈阳浑北灌区闸门安全评价

以《水闸安全鉴定管理办法》的评价指标体系为基础,引入层次分析法确定了指标权重,阐述了将层次分析法运用到灌区水闸安全评价的全过程,并以沈阳浑北灌区进行验证。结果表明,运用层次分析方法能对水闸的安全性作出全面、直观的评价,在一定程度上避免了评价中的主观影响。     

棉籽壳振动分离筛振动连板断裂事故分析

从振动力学和机械强度角度对棉籽壳振动分离筛连板断裂现象提出运动模型,并进行了分析计算,提出了相应的解决措施.     

电动振动台扩展台面的动力学性能分析

针对电动振动台系统中的部件——扩展台面，提出了一阶固有频率的有限元算法，建立了模态求解的数学方程式；并根据已有算法和数学方程进行了工程实例计算，计算结果与产品的实测数据吻合，为附加台面的有效设计提供了预评价方法。