全文获取类型
收费全文 | 4118篇 |
免费 | 428篇 |
国内免费 | 139篇 |
专业分类
电工技术 | 96篇 |
综合类 | 305篇 |
化学工业 | 1113篇 |
金属工艺 | 61篇 |
机械仪表 | 92篇 |
建筑科学 | 308篇 |
矿业工程 | 62篇 |
能源动力 | 26篇 |
轻工业 | 1667篇 |
水利工程 | 51篇 |
石油天然气 | 95篇 |
武器工业 | 7篇 |
无线电 | 161篇 |
一般工业技术 | 254篇 |
冶金工业 | 91篇 |
原子能技术 | 52篇 |
自动化技术 | 244篇 |
出版年
2024年 | 31篇 |
2023年 | 113篇 |
2022年 | 224篇 |
2021年 | 258篇 |
2020年 | 187篇 |
2019年 | 189篇 |
2018年 | 161篇 |
2017年 | 165篇 |
2016年 | 179篇 |
2015年 | 184篇 |
2014年 | 253篇 |
2013年 | 241篇 |
2012年 | 281篇 |
2011年 | 272篇 |
2010年 | 212篇 |
2009年 | 196篇 |
2008年 | 201篇 |
2007年 | 212篇 |
2006年 | 204篇 |
2005年 | 169篇 |
2004年 | 138篇 |
2003年 | 131篇 |
2002年 | 104篇 |
2001年 | 77篇 |
2000年 | 57篇 |
1999年 | 45篇 |
1998年 | 22篇 |
1997年 | 19篇 |
1996年 | 17篇 |
1995年 | 16篇 |
1994年 | 16篇 |
1993年 | 18篇 |
1992年 | 19篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1981年 | 1篇 |
1980年 | 6篇 |
1951年 | 1篇 |
排序方式: 共有4685条查询结果,搜索用时 15 毫秒
1.
David Diaz Elisa Lopez-Dolado Sergio Haro Jorge Monserrat Carlos Martinez-Alonso Dimitrios Balomeros Agustín Albillos Melchor Alvarez-Mon 《International journal of molecular sciences》2021,22(2)
Our aim was to investigate the subset distribution and function of circulating monocytes, proinflammatory cytokine levels, gut barrier damage, and bacterial translocation in chronic spinal cord injury (SCI) patients. Thus, 56 SCI patients and 28 healthy donors were studied. The levels of circulating CD14+highCD16−, CD14+highCD16+, and CD14+lowCD16+ monocytes, membrane TLR2, TLR4, and TLR9, phagocytic activity, ROS generation, and intracytoplasmic TNF-α, IL-1, IL-6, and IL-10 after lipopolysaccharide (LPS) stimulation were analyzed by polychromatic flow cytometry. Serum TNF-α, IL-1, IL-6 and IL-10 levels were measured by Luminex and LPS-binding protein (LBP), intestinal fatty acid-binding protein (I-FABP) and zonulin by ELISA. SCI patients had normal monocyte counts and subset distribution. CD14+highCD16− and CD14+highCD16+ monocytes exhibited decreased TLR4, normal TLR2 and increased TLR9 expression. CD14+highCD16− monocytes had increased LPS-induced TNF-α but normal IL-1, IL-6, and IL-10 production. Monocytes exhibited defective phagocytosis but normal ROS production. Patients had enhanced serum TNF-α and IL-6 levels, normal IL-1 and IL-10 levels, and increased circulating LBP, I-FABP, and zonulin levels. Chronic SCI patients displayed impaired circulating monocyte function. These patients exhibited a systemic proinflammatory state characterized by enhanced serum TNF-α and IL-6 levels. These patients also had increased bacterial translocation and gut barrier damage. 相似文献
2.
AbstractData mining techniques have been successfully utilized in different applications of significant fields, including medical research. With the wealth of data available within the health-care systems, there is a lack of practical analysis tools to discover hidden relationships and trends in data. The complexity of medical data that is unfavorable for most models is a considerable challenge in prediction. The ability of a model to perform accurately and efficiently in disease diagnosis is extremely significant. Thus, the model must be selected to fit the data better, such that the learning from previous data is most efficient, and the diagnosis of the disease is highly accurate. This work is motivated by the limited number of regression analysis tools for multivariate counts in the literature. We propose two regression models for count data based on flexible distributions, namely, the multinomial Beta-Liouville and multinomial scaled Dirichlet, and evaluated the proposed models in the problem of disease diagnosis. The performance is evaluated based on the accuracy of the prediction which depends on the nature and complexity of the dataset. Our results show the efficiency of the two proposed regression models where the prediction performance of both models is competitive to other previously used regression models for count data and to the best results in the literature. 相似文献
3.
Dr. Lina Liang Tong-You Wade Wei Pei-Yu Wu Wouter Herrebout Ming-Daw Tsai Prof. Stéphane P. Vincent 《Chembiochem : a European journal of chemical biology》2020,21(20):2982-2990
d -Glycero-d -manno-heptose-1β,7-bisphosphate (HBP) and d -glycero-d -manno-heptose-1β-phosphate (H1P) are bacterial metabolites that were recently shown to stimulate inflammatory responses in host cells through the activation of the TIFA-dependent NF-κB pathway. To better understand structure-based activity in relation to this process, a family of nonhydrolyzable phosphonate analogues of HBP and H1P was synthesized. The inflammation modulation by which these molecules induce the TIFA-NF-κB signal axis was evaluated in vivo at a low-nanomolar concentration (6 nM) and compared to that of the natural metabolites. Our data showed that three phosphonate analogues had similar stimulatory activity to HBP, whereas two phosphonates antagonized HBP-induced TIFA-NF-κB signaling. These results open new horizons for the design of pro-inflammatory and innate immune modulators that could be used as vaccine adjuvant. 相似文献
4.
Daniel H. Stones Anne-Marie Krachler 《International journal of molecular sciences》2015,16(2):2626-2640
The ability of bacterial species to colonize and infect host organisms is critically dependent upon their capacity to adhere to cellular surfaces of the host. Adherence to cell surfaces is known to be essential for the activation and delivery of certain virulence factors, but can also directly affect host cell signaling to aid bacterial spread and survival. In this review we will discuss the recent advances in the field of bacterial adhesion, how we are beginning to unravel the effects adhesins have on host cell signaling, and how these changes aid the bacteria in terms of their survival and evasion of immune responses. Finally, we will highlight how the exploitation of bacterial adhesins may provide new therapeutic avenues for the treatment of a wide range of bacterial infections. 相似文献
5.
稠油微生物开采技术现状及进展 总被引:2,自引:0,他引:2
综述了用微生物方法开采稠油的技术现状与进展,论题如下。①概述。②基本方法:异源微生物采油,包括微生物吞吐和微生物驱;本源微生物采油压大港孔店油田的实例。③主要机理,包括产表面活性剂,降解稠油中重质组分及其他。④技术研究,包括机理性、可行性及经济效益研究,列举了国内外6个实例。⑤现场应用,包括国外1个、国内6个实例。⑥该技术的优势及问题。参22。 相似文献
6.
内循环好氧三相流化床处理造纸中段废水 总被引:6,自引:0,他引:6
本实验采用内循环好氧三相流化床处造纸中段废水,经过一段时间的驯化,获得了稳定的出水。CDO去除经保持在65%以上,系统对进水污染负荷的变化具有较大的承受能力。出水Cl^-的浓度有所增加,说明驯化后的微生物可能对有抽氯化物具有一定的降解作用。水气比在1/120至1/140之间可获得最好的COD去除效果。后进行絮凝处理后,出水COD降为60-80mg/L,BODo 50-60/L,色度为100-150CU,挥发性酚的质量浓度小于0.0265mg/L。 相似文献
7.
8.
The coupling of the changes in bacterial quantitative and metabolic aspects during Microcystis aeruginosa bloom conditions together with several environmental parameters was studied in the hypereutrophic Villerest reservoir, France. Bacterial abundance varied from 5.20 to 21.28 × 106 bacteria-mL?1, while bacterial biomass ranged between 75 and 507 μg C mL?1. These results confirmed the highly eutrophic status of the Villerest reservoir. The relative quantitative importance of attached bacteria increased as Microcystis proliferated. Methyl-3H incorporation and D-(U-14C) glucose uptake varied from 8.99 to 60.57 × 106 cells-mL?1, and 0.016 to 1.587 μg CL?1 h?1, respectively. Correlations between several abiotic and biotic parameters showed that phytoplankton regulated bacterial growth by releasing organic carbon which is directly uptaken by heterotrophic bacteria. In the hypolimnion, the sedimentation of decaying algae represented a substantial substrate for bacterial growth. 相似文献
9.
Yong Ma Yong‐zhen Peng Xiao‐lian Wang Shu‐ying Wang 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(10):1118-1124
The laboratory scale anaerobic–anoxic–aerobic (A2O) process fed with synthetic brewage wastewater was designed to investigate the effects of changing feed C/P ratio on the performance of biological nutrient removal (BNR) processes. In the experiment, the influent chemical oxygen demand (COD) concentration was kept at approximately 300 mg L?1 while the total phosphorus concentration was varied to obtain the desired C/P ratio. Results showed that when the C/P ratio was lower than 32, phosphorus removal efficiency increased as C/P ratio increased linearly, while when the C/P ratio was higher than 32, the P removal efficiency was maintained at 90–98%, and effluent P concentration was lower than 0.5 mg L?1. However, regardless of the C/P ratio, excellent COD removal (90% or higher) and good total nitrogen removal (75–84%) were maintained throughout the experiments. It was also found that very good linear correlation was obtained between COD uptake per unit P released in the anaerobic zone and C/P ratio. In addition, the P content in the wasted activated sludge increased with the decrease in the C/P ratio. Based on the results, it was recommended that the wastewater C/P ratio and its effects be incorporated into BNR design and operational procedures, appropriate C/P ratios were used to achieve the effluent treatment goals. Copyright © 2005 Society of Chemical Industry 相似文献
10.
R. T. DeHoff 《Journal of microscopy》1985,138(2):143-151
Elements of surfaces that bound a phase (β) in a two phase mixture (α+β) may be classified as: (a) convex (++) if both principal curvatures are positive; (b) concave (? ?) if both are negative; and (c) saddle (+ ?) if one is positive and the other negative. This classification excludes the limiting cases for which one or both of the principal curvatures is zero. The traces of these surfaces that form the boundaries of the β areas on a representative two dimensional section may also be: (a) convex (+) if the local curvature is positive; or (b) concave (?) if it is negative. Line intercepts may be tabulated separately for intersections with convex (+) and concave (?) segments of boundary. This paper presents a derivation of fundamental stereological formulae that relate these counting measurements to three-dimensional geometric properties of the structure they sample. 相似文献