Extracellular Vesicles and Asthma—More Than Just a Co-Existence

Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.     

INTOOLS仪表设计软件的选择分析

介绍INTOOLS仪表设计软件的组成及功能,分析该软件成为目前世界上在仪表设计领 域运用比较广泛的仪表集成设计软件之一的原因,以及我们选择此软件实际应用的理由和价值。     

GAO Feng~1,LI Wei~2,TANG Zon

tific Experiment Center of Guangxi Medical University,Nanning 530021,China)Objective:To investigate the mutation pattern of adenomatous polyposis coli(APC),Kirsten-ras(K-ras) and p53 genes in sporadic colorectal cancer tissues.Meth     

Analyses and Solutions of Specific Cases in Spatial Angles Calculation

1 Introduction “Spatial Angles Calculations” means that all the calculations of given and unknown parameters are related to calculating angles in 3D space. The functions and relevant parameters in 3D space are much more complicated than that in 2D space, i.e. on a plane. Professor Sun, based on his research conducting for more than a decade, presented a series of new algorithms to calculate angles in space which are valuable in both theory and applications[1]. The authors found that, in g…     

Storage Changes of Fresh and Pasteurized Blue Crab Meat in Different Types of Packaging

We investigated pasteurization and storage of blue crabmeat in steel cans, aluminum cans, plastic cans, nonbarrier pouches, and barrier pouches. Fresh meat was packed in copolymer polyethylene/polypro-pylene cups, Saran® over-wrapped or vacuum skin packaged polystyrene trays, and nonbarrier pouches. Meat pasteurized in plastic and aluminum cans had better sensory and microbiological quality and longer shelf life than meat packed in steel cans. Oxygen-barrier pouches had the lowest quality and shortest shelf life. Nonbarrier pouches had product with quality similar to meat in steel cans, but with an extended shelf life. No packaging materials improved the microbiological shelf life of freshly cooked meat. Vacuum skin packaging resulted in improved sensory qualities of freshly cooked and picked meat.     

基于自适应共振理论(ART)网络的机床设备实例的分类

阐述了自适应共振理论(ART)网络的原理及训练算法.利用ART网络良好的自组织,自学习,可塑性强的特点,提出基于神经网络的机床设备实例分类的策略.该方法求解简单快速,容易实现,效率高,在实际工程中具有良好的应用前景.     

Safety-based availability assessment at design stage

The availability of a system or equipment is one of the crucial characteristics that measures the customer satisfaction and strongly influences his final choice decision between concurrent products. The aim of this work is to provide an approach to improve the products availability assessment by taking into account the safety criteria by considering the use situations at design stage. Our work focuses on the routine design of complex products. The availability is often simply estimated considering reliability and maintainability. Basically, the intrinsic availability is the probability that it is operating satisfactorily at any point in time when used under conditions stated by design specifications. The time considered includes operating time and active repair time. Thus, intrinsic availability excludes from consideration all other times in the product lifecycle such as: accident management time, storage time, administrative time or logistic time. But many studies show that the loss of availability performance is also due to accidents that occur in different unforeseeable utilization situations. This engenders stops of the system to ensure the users safety according to standards recommendations. In this purpose, we consider the structural product architecture and the different use cases that correspond to the operational states and downtimes due to stop events that may happen during the utilization like failures, maintenance tasks and accidents. Then, we propose a product behavioral analysis including the use cases to describe interactions between the product and users or maintenance operators. We use Markov chains to model the use cases corresponding to operating time (OT), maintenance time (MT) and preparing time after accidents (RT). Then these three parameters are considered to specify a generic approach to improve the availability assessment. Such an approach provides the traceability of the product behavior along its lifecycle. In this way, the main causes of stop can be identified and this may guide the designer for improving the availability of the product future versions. To validate our approach, an application is presented considering a printing line. The comparison of our simulation considering an industrial case study shows a good agreement about the influence of safety on the availability.     

Fuzzing技术的样本数据组合研究*

提出了基于样本数据组合的Fuzzing技术,并抽象出了解决样本数据覆盖问题（data sample covering problem,DSCP）的数学模型;为了更好地解决样本数据覆盖问题,提出了改进遗传算法(developed genetic algorithm,DGA),通过实例实验说明了DGA的有效性,并且通过仿真实验,验证了算法在求解复杂协议文件样本数据覆盖问题时比贪心算法和简单遗传算法具有更高的效率。