Twin screw granulation – review of current progress

Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique.     

低剂量抑制剂Inhibex501存在下的甲烷水合物相平衡研究

含动力学抑制剂的天然气水合物相平衡研究对新型低剂量抑制剂的开发具有指导作用。在283.6 ~ 290.9 K和7.51 MPa ~ 15.97 MPa的温压范围内研究了抑制剂Inhibex501及其溶剂2-乙二醇单丁醚对甲烷水合物相平衡条件的影响。实验结果显示，0.5wt%和2.0wt%浓度的Inhibex501对甲烷水合物形成的热力学条件具有促进作用，能使甲烷水合物形成移向更高的温度或者更低的压力，而2-乙二醇单丁醚在浓度0.2wt% ~ 1.0wt%范围几乎不改变甲烷水合物形成的热力学条件，N-乙烯基己内酰胺与N-乙烯基吡咯烷酮的共聚物对水合物形成热力学条件的改变起主要作用。     

Behavioral Phenotype of the Reeler Mutant Mouse: Effects of Reln Gene Dosage and Social Isolation.

Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

SBR工艺污泥膨胀的纠正方法

在对国内外有关资料的研究基础上，介绍了几种应对SBR反应池内污泥膨胀的措施。着重叙述了氯化法和无机合成絮凝剂法的应用注意点及如何定量运用这两种方法，同时给出了相应的工程实例。     

QUANTITATIVE ANALYSIS OF FLAVANOIDS IN BARLEY,HOPS AND BEER BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

This work describes a method for the quantitative analysis of flavanoids of barley, hops and beer by HPLC. This method requires only about 4 h and it gives representative and reproducible results. A few results obtained by this method are given for barley and hops.     

Application of a Compaction Simulator to the Design of a High-Dose Tablet Formulation. Part I

The compaction properties of an investigational drug are studied by the use of a compaction simulator. The effects of punch velocity over the range of 30-640 mm^-1 on the compaction properties of the pure drug and a variety of formulas incorporating a high dose of the active compound have been investigated. The data were analyzed by applying the Heckel equation. The pure drug was found to have a high yield pressure at a relatively low punch velocity of 31 mm^-1. As the punch velocity was increased there was a decrease in crushing strength, primarily as a result of increasing yield pressure. These findings indicate that the pure drug predominantly consolidated by fragmentation and elastic deformation, with a slow plastically deforming component. The information obtained on the consolidation mechanism of the pure drug and, subsequently, on model formulas were instrumental in the design and selection of a robust formula and granulation process. The advantages of conducting dosage form design and characterization studies during the early phase of tablet formulation using means such as a compaction simulator are emphasized in this investigation.     

Air entrainment in fresh concrete with PFA

The results of a study into the influence of PFA on air entrainment in fresh concrete are discussed It is shown that the required dosage of AEA to produce an air content of 5.5 ± 0.5% in a PFA modified concrete mix is two-six times that required in the corresponding neat OPC concrete mix. The dosage of a vinsol based air entraining agent (AEA) required appears to be directly related to the PFA content of the mix. Similar direct relationships were obtained with a range of different PFAs. The dosage of an AEA based on the salt of a fatty acid appears to be sensitive to both PFA and OPC contents. For the type of PFA used, the variability of measured air content or the amount of air retained after continued agitation both indicated that vinsol based AEAs show the highest variability whilst fatty acid based AEAs show low variability. The between batch variability of air content was significantly improved by the addition of PFA regardless of the AEA used.     

Integration of Data from Liquid–Liquid Phase Separation Databases Highlights Concentration and Dosage Sensitivity of LLPS Drivers

Liquid–liquid phase separation (LLPS) is a molecular process that leads to the formation of membraneless organelles, representing functionally specialized liquid-like cellular condensates formed by proteins and nucleic acids. Integrating the data on LLPS-associated proteins from dedicated databases revealed only modest agreement between them and yielded a high-confidence dataset of 89 human LLPS drivers. Analysis of the supporting evidence for our dataset uncovered a systematic and potentially concerning difference between protein concentrations used in a good fraction of the in vitro LLPS experiments, a key parameter that governs the phase behavior, and the proteomics-derived cellular abundance levels of the corresponding proteins. Closer scrutiny of the underlying experimental data enabled us to offer a sound rationale for this systematic difference, which draws on our current understanding of the cellular organization of the proteome and the LLPS process. In support of this rationale, we find that genes coding for our human LLPS drivers tend to be dosage-sensitive, suggesting that their cellular availability is tightly regulated to preserve their functional role in direct or indirect relation to condensate formation. Our analysis offers guideposts for increasing agreement between in vitro and in vivo studies, probing the roles of proteins in LLPS.     

含氰污水处理工程设计体会

龙泉金矿在全泥氰化提金过程中产生含氰化物１７４．７６ｍｇ／Ｌ的洗涤废水，通过碱式氯化法处理后，再由渣浆泵送入尾矿库进行自然净化作用，污水得到进一步净化，尾矿库溢流废水氰化物浓度低于０．５ｍｇ／Ｌ，废水排入小梅溪后，下游第一个居民取水点氰化物浓度低于０．００４ｍｇ／Ｌ，达到了国家规定的标准。     

给水处理投药控制的非线性数学模型及仿真

为了更好地控制给水处理系统中的投药量,本文用机理建模及分布参数系统建模的方法,建立了可用于给水处理投药过程控制的数学仿真模型,该仿真模型包括了给水处理过程中混凝、絮凝、沉淀3步最基本过程,反映了水厂各设计参数对水处理投药控制效果的影响以及混凝药剂与絮凝池、沉淀池出水浊度之间的动态响应关系.仿真模拟了水厂原水浊度发生突变对絮凝池及沉淀池的出水浊度的动态影响,仿真结果与实际水厂数据相近.研究结果可以用来进一步研究水处理过程控制,为更深入研究适用于给水处理的非线性控制方法提供良好的模拟仿真分析平台.