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Veronica Cocetta Vincenzo Quagliariello Francesco Fiorica Massimiliano Berretta Monica Montopoli 《International journal of molecular sciences》2021,22(4)
Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients. 相似文献
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D. P. Phillips, T. E. Ruth, and L. M. Wagner (1993) reported that 1969-1990 California mortality data show that Chinese Americans are particularly vulnerable to diseases that Chinese astrology and traditional Chinese medicine associate with their birth years. For example, because fire is associated with the heart, a Chinese person born in a fire year (such as 1937) is more likely to die of heart disease than is a Chinese person born in a nonfire year. However, many diseases were excluded from this study, some diseases that were included have ambiguous links to birth years, and the statistical tests were indirect. A more complete statistical analysis and independent California mortality data for the years 1960-1968 and 1991-2002 did not replicate the original results. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Psychoanalytic psychotherapy is threatened by two underlying social and economic developments. One is pressures of the marketplace that are altering all traditional professional relationships, threatening to undermine our familiar relationship with clients. The second is changes in the medical profession that call into question the appropriateness and utility of our long-standing link with medicine. The problems are explored and some suggestions put forth. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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中药大蜜丸及所用包装材料软、粘、轻、小、光,较难实现机械化自动包装。通常的监控方法不适合蜜丸的自动包装。采用红外线光电控制器,解决了自动包装蜜丸时出现的瞬间无纸、无丸等自动控制。 相似文献
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Scheduling emergency medicine residents (EMRs) is a complex task, which considers a large number of rules (often conflicting) related to various aspects such as limits on the number of consecutive work hours, number of day and night shifts that should be worked by each resident, resident staffing requirements according to seniority levels for the day and night shifts, restrictions on the number of consecutive day and night shifts assigned, vacation periods, weekend off requests, and fair distribution of responsibilities among the residents. Emergency rooms (ERs) are stressful workplaces, and in addition shift work is well-known to be more demanding than regular daytime work. For this reason, preparing schedules that suit the working rules for EMRs is especially important for reducing the negative impact on shift workers physiologically, psychologically, and socially. In this paper, we present a goal programming (GP) model that accommodates both hard and soft constraints for a monthly planning horizon. The hard constraints should be adhered to strictly, whereas the soft constraints can be violated when necessary. The relative importance values of the soft constraints have been computed by the analytical hierarchy process (AHP), which are used as coefficients of the deviations from the soft constraints in the objective function. The model has been tested in the ER of a major local university hospital. The main conclusions of the study are that problems of realistic size can be solved quickly and the generated schedules have very high qualities compared to the manually prepared schedules, which require a lot of effort and time from the chief resident who is responsible for this duty. 相似文献
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