A Smart Hyperthermia Nanofiber-Platform-Enabled Sustained Release of Doxorubicin and 17AAG for Synergistic Cancer Therapy

This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(ε-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.     

Deacetylated Cellulose Acetate/Polyurethane Composite Nanofiber Membranes with Highly Efficient Oil/Water Separation and Excellent Mechanical Properties

Nowadays, oil pollution has become more serious, which causes great threats both to the ecological environment and human life. In this study, a novel type of multifunctional deacetylated cellulose acetate/polyurethane (d-M_CA:M_TPU) composite nanofiber membranes for oil/water separation are successfully fabricated by electrospinning, which show super-amphiphilicity in air, super-hydrophilicity in oil, and oleophobicity in water. All the d-M_CA:M_TPU composite nanofiber membranes with different mass ratios can be used as water-removing, oil-removing, and emulsion separation substance only by gravity driving force. The highest separation flux for water and oil reaches up to 37 000 and 74 000 L m⁻² h⁻¹, respectively, and all the separation efficiencies are more than 99%. They have outstanding comprehensive mechanics performance, which can be controlled by simply adjusting the mass ratios. They show excellent antifouling and self-cleaning ability, endowing powerful cyclic stability and reusability. Those results show that d-M_CA:M_TPU composite nanofiber membranes have great application prospects in oil/water separation.     

Flexible poly(styrene-ethylene-butadiene-styrene) hybrid nanofibers for bioengineering and water filtration applications

Among the thermoplastic elastomers that play important roles in the polymer industry due to their superior properties, styrene-based species and polyurethane block copolymers are of great interest. Poly(styrene-ethylene-butadiene-styrene) (SEBS) as a triblock copolymer seems to have the potential to meet many demands in different applications due to various industrial requirements where durability, biocompatibility, breaking elongation, and interfacial adhesion are important. In this study, the SEBS triblock copolymer was functionalized with natural (Satureja hortensis, SH) and synthetic (nanopowder, TiO₂) agents to obtain composite nanofibers by electrospinning and electrospraying methods for use in biomedical and water filtration applications. The results were compared with thermoplastic polyurethane (TPU) composite nanofibers, which are commonly used in these fields. Here, functionalized SEBS nanofibers exhibited antibacterial effect while at the same time improving cell viability. In addition, because of successful water filtration by using the SEBS composite nanofibers, the material may have a good potential to be used comparably to TPU for the application.     

Research on hydrophobicity of electrospun Fe3O4/PVDF nanofiber membranes under different preparation conditions

Abstract

Preparation condition can affect the structure and the properties of nanofiber membrane. In order to explore suitable conditions to prepare the Fe₃O₄/PVDF nanofiber membrane with good hydrophobicity, the hydrophobicity of Fe₃O₄/PVDF nanofiber membranes obtained by electrospinning was investigated by changing preparation conditions like weight percentage of Fe₃O₄ nanoparticles, blending quality concentration of poly (vinylidene fluoride) (PVDF) and Fe₃O₄ nanoparticles, and positive voltage. And the variations of hydrophobicity of Fe₃O₄/PVDF nanofiber membranes modified by 1H, 1H, 2H, 2H-perfluorodecyl trimethoxysilane were studied. The results show that the hydrophobicity of Fe₃O₄/PVDF nanofiber membranes has changed under different preparation conditions. The contact angles of samples increased after a modification by 1H, 1H, 2H, 2H-perfluorodecyl trimethoxysilane, which indicates that the hydrophobicity of Fe₃O₄/PVDF nanofiber membranes has been enhanced.     

Effect of La doping on structural, magnetic and microstructural properties of Ba1 − x La x Fe12O19 ceramics prepared by citrate combustion process

La-substituted M-type barium ferrites, Ba_{1 − x} La _x Fe₁₂O₁₉, with x = 0.00–0.30 were successfully prepared via a citrate combustion process. Properties of the ceramics were characterized by powder X-ray diffraction, vibrating sample magnetometry and scanning electron microscopy. XRD patterns revealed only magnetoplumbite structure without minor phases. With increasing the La substituted content, the saturation magnetization (M _S ) was increased and reached to a maximum at x = 0.15 and then decreased but coercivity (H _C ) was increased. SEM micrographs of the dense ceramics showed the hexagonal platelet shape at low La content and the irregular shape at high La content.     

Affine Dependence Classification for Communications Minimization

This paper introduces results on placement and communications minimization for systems of affine recurrence equations. We show how to classify the dependences according to the number and nature of communications they may result in. We give both communication-free conditions and conditions for an efficient use of broadcast or neighbor-to-neighbor communication primitives. Since the dependences of a problem can generally not be all communication-free, we finally introduce a heuristic to globally minimize the communications based on the classification of dependences.     

Parallelization of WHILE loops on pipelined architectures

Modulo scheduling theory can be applied successfully to overlap Fortran DO loops on pipelined computers issuing multiple operations per cycle both with and without special loop architectural support. This paper shows that a broader class of loops—REPEAT-UNTIL, WHILE, and loops with more than one exit, in which the trip count is not known beforehand—can also be overlapped efficiently on multiple-issue pipelined machines. The approach is described with respect to a specific machine model, but it can be extended to other models. Special features in the architecture, as well as compiler representations for accelerating these loop constructs, are discussed. Performance results are presented for a few select examples.An earlier version of this paper was presented at Supercomputing '90.     

直扩接收机基带迟早门跟踪环的简化设计

针对要求设计简化、资源有限的设备和系统 ,通过对直扩接收机基带迟早门跟踪环的性能分析 ,在扩频增益比较大时 ,提出了一种简化设计结构 ,用两个由扩频码的部分序列构成的相关器分别替代原来早门和迟门的完全序列相关器。仿真表明该结构在给定足够的相关值情况下 ,性能略有恶化 ,但资源却得到较大节约 ,设计可大大简化。     

EIGENVECTORS-BASED PARALLELISATION OF NESTED LOOPS WITH AFFINE DEPENDENCES

Abstract

This paper presents a method for parallelising nested loops with affine dependences. The data dependences of a program are represented exactly using a dependence matrix rather than an imprecise dependence abstraction. By a careful analysis of the eigenvectors and eigenvalues of the dependence matrix, we detect the parallelism inherent in the program, partition the iteration space of the program into sequential and parallel regions, and generate parallel code to execute these regions. For a class of programs considered in the paper, the proposed method can expose more coarse-grain and fine-grain parallelism than a hyperplane-based loop transformation.