Tedesko’s Philadelphia Skating Club: Refinement of an Idea

This paper presents new aspects of Anton Tedesko’s design for an important thin shell concrete roof. The study of this roof results from the examination of original engineering drawings and calculations which we present with the goal of promoting a greater understanding of the structural design of a major figure in the tradition of 20th century building.     

新型重整催化剂的研究——Pt／L中沸石酸碱性的作用

Ｐｔ／ＫＬ、Ｐｔ／ＢａＫＬ及Ｐｔ／ＨＬ上的铂与沸石的酸碱位发生相互作用，导致催化剂上存在不同电子状态和粒度分布的铂位，从而产生有着完全不同催化作用、不同抗硫性能的两类催化剂，即以碱性沸石为载体的“单功能”催化剂和以酸性沸石为载体的“双功能”催化剂。在Ｐｔ／ＫＬ、Ｐｔ／ＢａＫＬ催化剂上，存在着对硫敏感的具有环化脱氢功能和对硫不敏感的仅具有脱氢功能的两类铂活性位。     

SO_4~(2-)-Fe_2O_3/Hβ增强酸催化剂上合成乙酸丁酯

将超强酸中心引入Ｈβ沸石表面，制备出具有增强酸性的ＳＯ２－４－Ｆｅ２Ｏ３／Ｈβ催化剂，并用于乙酸与正丁醇的酯化反应。采用数学模拟方法定量表征该催化剂的酸强度分布。建立了合成乙酸丁酯反应动力学模型。讨论不同类型沸石、氧化物改性对酯化反应性能的影响及表面酸性与酯化性能的关系。     

静态水热脱铝处理对HZSM-5分子筛的结构、酸性和催化性能的影响

开发了一种静态水热脱铝的方法。HZSM-5经此法处理后,正戊烷的裂解活性增加,脱氢和芳构化性能加强。可用改变处理温度的方法来控制脱铝的程度。用XRD和吡啶吸附红外技术进行了研究。HZSM-5分子筛催化剂性能的变化用非骨架铝产生的强L酸中心来解释。     

Ammoxidation of methylaromatics over vanadium phosphate catalysts II. Catalyst formation, active sites and reaction mechanism

The interactions of VOHPO₄· 0.5H₂O and (VO)₂P₂O₇ with the ammoxidation feed and the single components such as ammonia, oxygen, water and component mixtures were studied in detail using XRD and temperature-programmed reaction spectroscopy. The aim of this work was to improve the knowledge of the formation of the active phases or active sites of the catalysts from their precursors under the condition of the ammoxidation reaction. Similar catalytic properties of various applied VPO materials were discussed in terms of the presence of similar structure elements (domains of adjacent edge-sharing VO₆ octahedra-units and P-O-NH₄ groups).     

河南洛阳天津桥的演变史

河南洛阳龙门道上，有一孔古朴的石拱桥，上建小亭，为隋唐天津桥故址残迹。天津桥经历了的历代的兴衰，见证了从隋炀帝大业元年到新中国成立后的历史和发展。     

福禄宫“蝼蜂窠”制作技术初探

福禄宫位于湖南长沙市城西区,始建于清代光绪年间。解放后,福禄宫因未及时修理维护,朽损情况严重,1983年底被拆毁。通过对残留木制装修构件拼凑,推算出该建筑的蝼蜂窠部分测绘图。福禄宫蝼蜂窠类似于北方斗栱中的平身科,是一种装饰性构件。福禄宫的昂嘴采用翼龙飞凤交错排列的形式,部分昂嘴端部另加雕饰花板。蝼蜂窠采用层层叠置出踩的形式,其表面只施以桐油或光油等透明涂料,未施其它色漆及彩绘。     

The Histidine Phosphocarrier Kinase/Phosphorylase from Bacillus Subtilis Is an Oligomer in Solution with a High Thermal Stability

The histidine phosphocarrier protein (HPr) kinase/phosphorylase (HPrK/P) modulates the phosphorylation state of the HPr protein, and it is involved in the use of carbon sources by Gram-positive bacteria. Its X-ray structure, as concluded from crystals of proteins from several species, is a hexamer; however, there are no studies about its conformational stability, and how its structure is modified by the pH. We have embarked on the conformational characterization of HPrK/P of Bacillus subtilis (bsHPrK/P) in solution by using several spectroscopic (namely, fluorescence and circular dichroism (CD)) and biophysical techniques (namely, small-angle X-ray-scattering (SAXS) and dynamic light-scattering (DLS)). bsHPrK/P was mainly a hexamer in solution at pH 7.0, in the presence of phosphate. The protein had a high conformational stability, with an apparent thermal denaturation midpoint of ~70 °C, at pH 7.0, as monitored by fluorescence and CD. The protein was very pH-sensitive, precipitated between pH 3.5 and 6.5; below pH 3.5, it had a molten-globule-like conformation; and it acquired a native-like structure in a narrow pH range (between pH 7.0 and 8.0). Guanidinium hydrochloride (GdmCl) denaturation occurred through an oligomeric intermediate. On the other hand, urea denaturation occurred as a single transition, in the range of concentrations between 1.8 and 18 µM, as detected by far-UV CD and fluorescence.     

Regulatory Light Chains in Cardiac Development and Disease

The role of regulatory light chains (RLCs) in cardiac muscle function has been elucidated progressively over the past decade. The RLCs are among the earliest expressed markers during cardiogenesis and persist through adulthood. Failing hearts have shown reduced RLC phosphorylation levels and that restoring baseline levels of RLC phosphorylation is necessary for generating optimal force of muscle contraction. The signalling mechanisms triggering changes in RLC phosphorylation levels during disease progression remain elusive. Uncovering this information may provide insights for better management of heart failure patients. Given the cardiac chamber-specific expression of RLC isoforms, ventricular RLCs have facilitated the identification of mature ventricular cardiomyocytes, opening up possibilities of regenerative medicine. This review consolidates the standing of RLCs in cardiac development and disease and highlights knowledge gaps and potential therapeutic advancements in targeting RLCs.     

Quest for the Crypto-phosphoproteome

Protein phosphorylation is one of the most studied post-translational modifications (PTMs). Despite the remarkable advances in phosphoproteomics, a chemically less-stable subset of the phosphosites, which we call the crypto-phosphoproteome, has remained underexplored due to technological challenges. In this Viewpoint, we briefly summarize the current understanding of these elusive protein phosphorylations and identify the missing pieces for future studies.