Micro‐Raman Spectroscopy Study of Human Pterygium and Conjunctival Melanocytic Nevi

Pterygium, a common ophthalmic disease that is caused by fibrovascular growth of conjunctiva and conjunctival melanocytic nevi that is another conjunctival disease, are detected by Raman spectroscopy in the present study. We find that there is an obvious increase in the intensity at the peak of 1,583 cm^?1 that is assigned to C=C unsaturated fatty acids stretch of lipids in the pterygium tissue, and 1,639 cm^?1 also increased which belongs to amide I. Also, PCA (Principal Component Analysis) was used to classify the normal conjunctiva from the pterygium tissue. For the conjunctival melanocytic nevi, the intensity of Raman spectrum region between 1,550 cm^?1 and 1,650 cm^?1 that belong to protein has increased, which indicates that the content of protein in conjunctival melanocytic nevi is more richer than the normal ones. SCANNING 34: 395–398, 2012. © 2012 Wiley Periodicals, Inc.     

润尔乐滴眼液治疗翼状胬肉术后角膜上皮愈合不良的疗效观察

目的观察润尔乐滴眼液对翼状胬肉术后角膜上皮愈合不良的治疗效果。方法随机将48例翼状胬肉术后角膜上皮愈合不良患者分为2组,一组给予人工泪液滴眼,另一组给予润尔乐滴眼液滴眼,分别观察2组患者角膜上皮的修复情况。结果使用润尔乐滴眼液组临床症状缓解迅速,角膜上皮修复良好。结论对翼状胬肉术后角膜上皮愈合不良的患者使用润尔乐滴眼液滴眼,可以较好地缓解眼部刺激症状,并能有效地促进角膜上皮修复。     

翼状胬肉切除并生物羊膜移植术治疗翼状胬肉的疗效

目的探讨翼状胬肉切除并生物羊膜移植术治疗翼状胬肉的临床疗效。方法将117例（155眼）翼状胬肉患者根据手术方式不同分为2组：治疗组72例（93眼）和对照组45例（62眼）。治疗组采用翼状胬肉切除并生物羊膜移植术,对照组采用传统的翼状胬肉切除术。结果 2组患者术后均随访1年,治疗组、对照组翼状胬肉复发分别为6眼（6.5%）、15眼（24.2%）,2组翼状胬肉复发率比较差异有统计学意义（P〈0.05）。结论采用翼状胬肉切除并生物羊膜移植术治疗翼状胬肉可以明显的降低术后复发率,并能改善创面愈合。     

DHA-丝裂霉素C偶联前药的制备 及角膜透过性研究

为了降低丝裂霉素C(MMC)在治疗翼状胬肉时经角膜吸收所导致的副作用,将其与DHA偶联为前药DHA-MMC。经离体角膜透过性实验及体外释放实验,结果发现:增大的相对分子质量可阻断MMC的角膜吸收,以避免其眼内副作用;MMC可以前药(DHA-MMC)形式积聚在眼表后逐渐释放MMC以产生活性。     

进行期翼状胬肉的透射电镜观察

本文采用ＨＵ－１２Ａ透射电镜对１０份进行翼状胬肉标本进行观察，结果发现翼状胬肉中存在正常及异常弹性纤维和胶原纤维，角膜上皮细胞下由于增生纤维的侵入，使Ｂｏｗｍｅｎ氏膜破坏。