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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Kathleen T. Lauser Amy L. Rueter Michelle A. Calabrese 《American Institute of Chemical Engineers》2022,68(12):e17850
While protein medications are promising for treatment of cancer and autoimmune diseases, challenges persist in terms of development and injection stability of high-concentration formulations. Here, the extensional flow properties of protein-excipient solutions are examined via dripping-onto-substrate extensional rheology, using a model ovalbumin (OVA) protein and biocompatible excipients polysorbate 20 (PS20) and 80 (PS80). Despite similar PS structures, differences in extensional flow are observed based on PS identity in two regimes: at moderate total concentrations where surface tension differences drive changes in extensional flow behavior, and at small PS:OVA ratios, which impact the onset of weakly elastic flow behavior. Undesirable elasticity is observed in ultra-concentrated formulations, independent of PS identity; higher PS contents are required to observe these effects than in analogous polymeric excipient solutions. These studies reveal novel extensional flow behaviors in protein-excipient solutions, and provide a straightforward methodology for assessing the extensional flow stability of new protein-excipient formulations. 相似文献
2.
A Pitot tube is a popular device used for the measurements of flow fields. To control the accuracy of the Pitot tube coefficient, the international standard organization (ISO), the American Society for Testing and Materials (ASTM), and the Japanese Industrial Standards (JIS) issued guidelines that recommended the shape and working conditions of these devices. However, many Pitot tubes on the market do not follow these guidelines. In the present study, various types of Pitot tubes in the market were tested at the National Metrology Institute of Japan (NMIJ) to determine the effects of the geometry and flow characteristics. The results revealed certain limitations in the existing ISO and JIS standards, specifically with regard to the recommended design parameters of the AMCA Pitot tube, the reference coefficient value for the JIS Pitot tube, and the redefinition and limitation of Reynolds numbers pertaining to Pitot tube working conditions. 相似文献
3.
Niccolò Renoldi Seyed Hadi Peighambardoust Donatella Peressini 《International Journal of Food Science & Technology》2021,56(7):3235-3244
In this work, corn extruded snack products were enriched with rice bran (RB) at 10% and 15%. A co-rotating twin-screw extruder was used with a feed moisture content of 16 g 100 g−1, a screw speed of 240 r.p.m. and four heating sections of the barrel (100, 140, 150 and 150 °C). The impact of RB inclusion on nutritional profile, starch digestion, physicochemical and textural properties of snack products was evaluated. RB-enriched extrudates showed a lower specific volume and hardness and higher crispness than control. RB at 15% gave a water-holding capacity lower than control. Rheology of extrudate dispersions indicated an increase in elastic interactions and solid-like behaviour with RB supplementation. Differences in rheological properties resulted in attenuation of predictive glycaemic response for RB-enriched snacks. 相似文献
4.
In the present work, two types of shear thickening fluids have been synthesized by using neat and aminosilane functionalized silica nanoparticles and their viscosity curves have been obtained by the rheometer. Based on the values of peak viscosity of synthesized shear thickening fluids, the surface functionalized nanosilica based shear thickening fluid has been chosen as a best candidate due to the high viscosity for impregnation into the neat Kevlar of different layers viz. four (04) and eight (08) layers for velocity impact study. The experimental investigations reveal high energy absorption of shear thickening fluid impregnated Kevlar as compared to the neat Kevlar. The maximum energy absorption 62 J is achieved corresponding to the initial velocity 154 m∙s−1 for 08 layers shear thickening fluid impregnated Kevlar specimen. The data have also been analytically determined and validated with the experimental data. The experimental data have good agreement with the analytical data within the accuracy of around 15 to 20%. The present findings can have significant inferences towards the fabrication of shear thickening fluids using nanomaterials for numerous applications such as soft armors, dampers, nanofinishing and so forth. 相似文献
5.
以重庆市甄子岩29号危岩体为研究对象,基于现场调查和分析解剖,建立UDEC离散元数值计算模型,对其演化变形过程进行模拟分析。研究表明,在巨大的自重作用下,由于基座岩体岩质软,岩体较破碎,且基座外侧为直立的陡崖,具有完整的临空面,从而使基座岩体易发生压缩流变及剪切流变,进而使危岩体存在滑移垮塌的危险。 相似文献
6.
为研究钢管套筒灌浆连接轴向受拉破坏过程及破坏机理,试验中设计了16组48个钢管套筒灌浆连接试件,试件采用钢板代替圆钢管,并进行静载试验。分析了灌浆料裂缝扩展过程、荷载-相对位移曲线,并对抗剪键高距比、灌浆料厚度、侧向力等因素对破坏过程及承载力的影响进行分析。结果表明:对于不设置抗剪键的套筒灌浆连接试件,斜裂缝随机产生,裂缝分布不均匀;对于设置抗剪键的套筒灌浆连接试件,裂缝首先出现在底部抗剪键位置处,与水平方向夹角约为30°,随后在中部和上部抗剪键位置处分别出现斜裂缝。由于每个抗剪键上荷载分担并不均匀,与抗剪键接触的灌浆料逐渐达到极限压应力,达到极限状态时,承载力全部由抗剪键间的机械咬合力承担,在连接承载力中,可忽略摩擦力和胶结力作用。随着抗剪键高距比h/s增大,各试件初始剪切刚度相差不大,承载力增大,但增幅逐渐减小,建议抗剪键高距比0.06g/s>0.3,同时需要满足灌浆料灌注的施工要求。 相似文献
7.
8.
Mechanical durability of extruded fish feed must be optimized to lower economic losses as well as emission of organic matter to aquatic environments. The glass transition hypothesis for viscoelastic biopolymers is demonstrated and confirmed experimentally to be valid for extruded fish feed pellets. It is proposed and demonstrated that it is important to avoid early glass transition onset, to optimize the obtained mechanical durability. From the proposed glass transition hypothesis, immediate process relevance to the pre-drying transport mechanism is demonstrated. Furthermore, measured mechanical durability is found to range from 1.5 to 5.0% loss, for different combinations of drying parameters. 相似文献
9.
Alberto Ballesteros Ester Laguna-Gutierrez Paula Cimavilla-Roman Maria Luisa Puertas Antonio Esteban-Cubillo Julio Santaren Miguel Angel Rodriguez-Perez 《应用聚合物科学杂志》2021,138(46):51373
In the present work blends of polystyrene (PS) with sepiolites have been produced using a melt extrusion process. The dispersion degree of the sepiolites in the PS has been analyzed by dynamic shear rheology and X-ray micro-computed tomography. Sepiolites treated with quaternary ammonium salts (O-QASEP) are better dispersed in the PS matrix than natural sepiolites (N-SEP) or sepiolites organo-modified with silane groups (O-SGSEP). A percolated network is obtained when using 6.0 wt% of O-QASEP, 8.0 wt% of N-SEP and 10.0 wt% of O-SGSEP. It has been shown that multiple extrusion processes have a negative effect on the polymer architecture. They produce a reduction in the length of the polymeric chains, and they do not lead to a better dispersion of the particles in the polymer matrix. Foams have been produced using a gas dissolution foaming process, where a strong effect of the dispersion degree on the cellular structure of the different foams was found. The effects on the cellular structure obtained by using different types of sepiolites, different contents of sepiolites and different extrusion conditions have been analyzed. The foams produced with the formulations containing O-QASEP present the lowest cell size and the most homogeneous cellular structures. 相似文献
10.
Linear-viscoelastic characteristics and performance are evaluated throughout the blending process of polyethylene and polypropylene with bitumen. Results indicate that type, form and percentage of polyolefin play a significant role in the time evolution of the composite's mechanical response. Toluene extraction of modified bitumen revealed, for the first time, the formation of a sponge-like polymer network. Visual inspection and Fourier transform infrared analysis of the polyolefins recovered after extraction indicates higher affinity of the polyethylene with bitumen in agreement with the rheological test results. The use of polypropylene is discouraged if rutting performance is a concern, and polyethylene in both pellets and powder form at 4%, and after 210 min of blending produces a modified bitumen with acceptable performance. 相似文献