转基因大豆油的安全性研究--动物实验

以转基因大豆油为原料,对其在急性毒性实验、长期毒性实验、病理组织学检查等几方面进行安全性的研究,结论显示转基因大豆油在中长期内食用是安全的,但还需要对慢性毒性实验以及不同加工工艺下的产品进行进一步的验证.     

Multiple roles of adrenomedullin revealed by animal models

The newly identified adrenomedullin (AM) gene codes for a potent, highly conserved vasodilator that is expressed in many tissues. Many biological functions have been ascribed to AM based on its broad expression pattern and numerous in vitro studies, and it is currently viewed as a multifunctional peptide hormone. Recent advances in gene manipulation have permitted the development of experimental animal systems to help distinguish between gene causes and effects in the context of otherwise normal physiology, and so the normal biological function of the AM gene can be studied within the intact physiological milieu of a whole animal. In this review article, we summarize the recent findings from three different types of genetic experiments involving the AM gene.     

转基因油料油脂的优劣性

通过对转基因油料、油脂特征指标测定,并与非转基因油料、油脂特征指标进行对比分析,评价转基因油料、油脂的优劣性.结果表明,转基因油料、油脂在特征指标和脂肪酸组成上与非转基因油料、油脂无明显的差别.     

MS-based analytical methodologies to characterize genetically modified crops

The development of genetically modified crops has had a great impact on the agriculture and food industries. However, the development of any genetically modified organism (GMO) requires the application of analytical procedures to confirm the equivalence of the GMO compared to its isogenic non-transgenic counterpart. Moreover, the use of GMOs in foods and agriculture faces numerous criticisms from consumers and ecological organizations that have led some countries to regulate their production, growth, and commercialization. These regulations have brought about the need of new and more powerful analytical methods to face the complexity of this topic. In this regard, MS-based technologies are increasingly used for GMOs analysis to provide very useful information on GMO composition (e.g., metabolites, proteins). This review focuses on the MS-based analytical methodologies used to characterize genetically modified crops (also called transgenic crops). First, an overview on genetically modified crops development is provided, together with the main difficulties of their analysis. Next, the different MS-based analytical approaches applied to characterize GM crops are critically discussed, and include "-omics" approaches and target-based approaches. These methodologies allow the study of intended and unintended effects that result from the genetic transformation. This information is considered to be essential to corroborate (or not) the equivalence of the GM crop with its isogenic non-transgenic counterpart.