Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Enzyme Deficiency

We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched by an age range of young adults (18–31 years) with 20 control subjects (8 male and 12 female). Dual energy X-ray absorptiometry was used to measure the fat distribution. Male patients demonstrated elevated indices of fat mass for total (7.7 ± 2.1 vs. 4.5 ± 1.3 kg/m², p = 0.003), trunk (4.0 ± 1.2 vs. 2.2 ± 0.8 kg/m², p = 0.005), android (0.63 ± 0.24 vs. 0.32 ± 0.15 kg/m², p = 0.008), gynoid (1.34 ± 0.43 vs. 0.74 ± 0.24 kg/m², p = 0.005), arm (0.65 ± 0.16 vs. 0.39 ± 0.10 kg/m², p = 0.009), and leg regions (2.7 ± 0.8 vs. 1.6 ± 0.4 kg/m², p = 0.005) than the control group, but not in females. However, female patients demonstrated elevated ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (1.90 ± 0.46 vs. 1.39 ± 0.47, p = 0.009) than the control group, but not in males. Total fat mass was inversely correlated with total testosterone (r = −0.64, p = 0.014) and positively correlated with leptin in males (r = 0.75, p = 0.002). An elevated daily HDE (β = 0.43, p = 0.038 and β = 0.47, p = 0.033) and trunk to total fat mass ratio (β = 0.46, p = 0.025, and β = 0.45, p = 0.037) were independently correlated with impaired lipid profile markers. Although there is no altered lipid profile, male patients demonstrated an increased fat distribution. However, female patients presented with an impaired lipid profile marker but demonstrated close values of normal fat distribution. Interestingly, the dose of glucocorticoid therapy can have some role in the lipid mechanisms.     

The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

The mammalian cell cycle is important in controlling normal cell proliferation and the development of various diseases. Cell cycle checkpoints are well regulated by both activators and inhibitors to avoid cell growth disorder and cancerogenesis. Cyclin dependent kinase 20 (CDK20) and p21^Cip1/Waf1 are widely recognized as key regulators of cell cycle checkpoints controlling cell proliferation/growth and involving in developing multiple cancers. Emerging evidence demonstrates that these two cell cycle regulators also play an essential role in promoting cell survival independent of the cell cycle, particularly in those cells with a limited capability of proliferation, such as cardiomyocytes. These findings bring new insights into understanding cytoprotection in these tissues. Here, we summarize the new progress of the studies on these two molecules in regulating cell cycle/growth, and their new roles in cell survival by inhibiting various cell death mechanisms. We also outline their potential implications in cancerogenesis and protection in heart diseases. This information renews the knowledge in molecular natures and cellular functions of these regulators, leading to a better understanding of the pathogenesis of the associated diseases and the discovery of new therapeutic strategies.     

基于实际井眼轨迹的抽油杆柱API设计方法

目前的抽油杆柱设计方法大都基于设计井眼轨迹或经验公式，因此设计的抽油杆柱与井眼的匹配性并没有达到最优，结果可能影响了抽油杆柱的受力特性和寿命。概述了目前现有的抽油杆柱设计方法，提出了基于实际井眼轨迹的抽油杆柱API设计方法，即考虑到在三维空间中井下粘滞阻力及动载的影响，利用微单元分析方法计算出轴向载荷与轴向应力，然后在此基础上进行杆柱组合设计，并给出了设计流程。以江苏油田永21-3井为例，对几种设计方法的设计结果进行了对比分析，结果表明，江苏油田目前采用的抽油杆柱设计方法包含了人为经验因素，并不是最优的杆柱设计结果，有待进一步改进。     

基于ADSP21XXC运行环境下FFT的实现

介绍了数字信号处理器ADSP21XX芯片的特点以及实现FFT(快速离散付里叶变换)的方法，给出了ADSP21XX的C和汇编混合编程的特点及技巧。     

曲靖经济区水资源持续利用及车马碧调水工程

1曲靖经济区水资源开发利用现状 云南省曲靖市经济区（特指麒麟、沾益、陆良3个区县的南盘江沾曲陆段）区域内人均水资源量892m^3／人，仅为云南省人均水资源量的17．8％，也只有全国平均水平的40．2％，属水资源紧张地区，现状水资源开发利用程度已达到41．7％。在云南省委省政府提出“与全国同步实现建设小康社会宏伟目标”、“工业强省倍增计划”等的发展战略，以及曲靖市提出“珠江源大城市”和“曲靖工业强市”战略的实施，城市生活和工业需水量将快速增长，水资源的供需矛盾越来越突出，研究南盘江上游的曲靖经济区水资源配置是十分紧迫和必要的。     

EFFECT OF AGING ON HYDROGEN EMBRITTLEMENT SUSCEPTIBILITY OF STEEL Cr21Ni6Mn9N

Effects of 650℃ aging for 1—1000 h on structure and hydrogen embrittlement susceptibility(HES)of steel Cr21Ni6Mn9N have been investigated.The results show that M_(23)C_6 typecarbide precipitates at grain boundaries and Cr-depletive region appears beside them duringaging.The precipitates grow and connect each other as the aging time prolongs.Meanwhile,the degree of Cr-depletion aggravates first and then recovers gradually while the aging time isvery long,i.e.,1000 h.The HES of the steel increases with increasing aging time but does notreduce with the recovery of Cr content at the Cr-depletive region.That implies that the ex-isting of carbides at grain boundaries might be the main reason which promotes the HES ofsteel during aging.     

基于MIKE FLOOD的洪泽湖周边滞洪区洪水演进模拟研究

基于实测断面资料建立了研究区的一维水动力模型,基于高精度DEM以及1∶10000地形图建立了研究区的二维水动力模型,并用MIKE FLOOD将一维模型和二维模型进行耦合,构建了洪泽湖周边滞洪区一、二维耦合的洪水演进数学模型。利用2003年历史洪水资料对模型参数进行了率定,并以2007年历史洪水资料进行了验证。以洪泽湖百年一遇设计洪水为模型上边界,二河闸、三河闸以及高良涧闸的现行调度方案的水位-流量关系为模型下边界,对洪泽湖百年一遇设计洪水方案进行模拟计算,当蒋坝水位达到14.33m时,洪泽湖周边滞洪区开始滞洪,得到开始滞洪后不同时段研究区内各类洪水风险要素的动态分布情况以及最大淹没水深、淹没历时,验证了模型的合理性,可用于蓄滞洪区洪水演算分析。     

Flood Inundation Modelling for Mid‐Lower Brisbane Estuary

This study utilizes a two‐dimensional hydrodynamic model to calibrate and validate an inundation model for the Brisbane River estuary in Queensland, Australia. The bathymetry data used in the hydraulic model are derived from one arc second (1 s) shuttle radar topography mission digital elevation model, and the two‐dimensional hydraulic model is parameterized using the generated bathymetry with four open boundaries with water level observations and roughness coefficients. The calibration performance is evaluated by comparing the simulated results with the digitized records during the January 2013 flood event (a low magnitude event) at three gauging stations. The calibrated model is validated with water level data and available discharge data during the January 2011 flood (a large magnitude event) at four gauging stations located along the Brisbane River. Different performance indices are applied to demonstrate that the developed model performs well during calibration and validation. A sensitivity analysis is presented to assess the influence of riverbed elevation changes on the model because the main uncertainty of the model is the bathymetry data. The proposed model with the shuttle radar topography mission digital elevation model‐derived riverbed elevation for the Brisbane estuary is able to predict the flood inundation extent at an accuracy of 66.9% which is higher than or comparable with the accuracies of the existing studies. However, it is expected that the accuracy will increase if some improved bathymetry data become available in the future. Copyright © 2016 John Wiley & Sons, Ltd.     

近海人工岛及沙坝工程与潮流的响应特征研究

北戴河新区位于最具发展潜力的环渤海经济圈中心地带,为满足旅游业发展需要而建的人工岛和保护旅游海滩而建的人工沙坝对近海潮流动力有不同程度的影响。该文基于MIKE21 FM模块通过大、中、小模型三层嵌套的方式建立洋河-葡萄岛近岸海域潮流数学模型,研究分析人工岛及沙坝工程建设前后的潮流动力变化特征,得到下列主要结论:工程建设后研究区域的主体潮流特征仍为顺岸往复流,流速变化量涨潮大于落潮;人工岛工程对流速场的影响范围和程度均明显大于沙坝工程,其中人工岛工程引起的流速变化量是沙坝工程的4倍;人工岛的建设使其内部形成一个相对封闭的水域,流速近乎为零,而养滩工程区在两侧水工建筑物和水下人工沙坝的掩护作用下流速基本减小至0.10 m/s以下。     

基于MIKE Flood的中小河流溃堤洪水演进数值模拟

针对水文资料缺乏的中小河流,以贵溪市罗塘河下游段为例,应用MIKE软件对河流溃堤洪水演进进行了研究。采用瞬时单位线法推求断面各频率的设计洪水,并将其作为洪水演进模型的输入;利用MIKE软件建立了贵溪市罗塘河下游段的一、二维耦合水动力模型,对该河下游段溃堤洪水演进过程进行了模拟;通过模拟分析,得到了溃口流量过程和堤防保护区洪水淹没过程。研究成果可为中小河流洪水风险分析和灾害损失评估提供技术支撑。