侵入物高速撞击下铰链式动车组的安全性

为探究侵入物高速撞击下铰链式动车组的安全性,在实物三维扫描重构的基础上,构建一种新的活体三维有限元层叠模型,并在LS-DYNA中进行摆锤侧面碰撞分析验证;通过铰链式动车组与活体在110 km/h速度下的碰撞仿真计算,讨论动车组运行的安全性以及吸能装置的可靠性.结果 显示:活体的有限元层叠模型既能保证计算精度,又能提高计算效率;在110 km/h的碰撞速度下,车体加速度为0.117g,轮对抬升量为0.238 mm,车钩每5 m长度的压缩量最大约为1.89 mm.各项指标都低于EN 15227标准,动车组行车安全性没有受到影响,吸能装置也能可靠工作.     

Aberrant protein expression in plasma and kidney tissue during experimental obstructive nephropathy

Kidney failure is a major health problem worldwide. Patients with end-stage renal disease require intensive medical support by dialysis or kidney transplantation. Current methods for diagnosis of kidney disease are either invasive or insensitive, and renal function may decline by as much as 50% before it can be detected using current techniques. The goal of this study was, therefore, to identify biomarkers of kidney disease (associated with renal fibrosis) that can be used for the development of a non-invasive clinical test for early disease detection. We utilized two protein-profiling technologies (SELDI-TOF MS and 2-D) to screen the plasma and kidney proteome for aberrantly expressed proteins in an experimental mouse model of unilateral uretric obstruction, which mimics the pathology of human renal disease. Several differentially regulated proteins were detected at the plasma level of day-3-obstructed animals, which included serum amyloid A1, fibrinogen α, haptoglobin precursor protein, haptoglobin and major urinary proteins 11 and 8. Differentially expressed proteins detected at the tissue level included ras-like activator protein 2, haptoglobin precursor protein, malate dehydrogenase, α enolase and murine urinary protein (all p<0.05 versus controls). Immunohistochemistry was used to confirm the up-regulation of fibrinogen. Interestingly, these proteins are largely separated into four major classes: (i) acute-phase reactants (ii) cell-signaling molecules (iii) molecules involved in cell growth and metabolism and (iv) urinary proteins. These results provide new insights into the pathology of obstructive nephropathy and may facilitate the development of specific assay(s) to detect and monitor renal fibrosis.     

基于三角形试验的引张线卡阻位置定位分析

引张线广泛应用于大坝水平位移监测,但在长期运行过程中会因线体卡阻而影响观测成果的真实性。因引张线的护管为不透明的PVC管或镀锌管,直接观察引张线卡阻部位存在一定难度,更换整根护管也显得不经济。为经济有效地消除卡阻,介绍运用三角形试验来准确判定卡阻位置的方法,并给出了相关计算公式。工程实例验证表明,该方法可准确找到卡阻位置,为以后引张线卡阻问题处理提供了参考。     

三山岛金矿新立分矿通风系统的研究及应用

新立矿井是新建大型黄金矿井,深度大,生产中段多,自投产以来,通风效果一直不理想,通过对矿井通风系统阻力测定数据的分析,提出通风系统的技改措施,并进行技术经济论证,以优化井下通风系统,达到建设经济节能型矿井目的。     

The Role of the Lymphatic System in the Pathogenesis and Treatment of Inflammatory Bowel Disease

Although the number of therapeutic options for the treatment of inflammatory bowel disease (IBD) has increased in recent years, patients suffer from decreased quality of life due to non-response or loss of response to the currently available treatments. An increased understanding of the disease’s etiology could provide novel insights for treatment strategies in IBD. Lymphatic system components are generally linked to immune responses and presumably related to inflammatory diseases pathophysiology. This review aims to summarize findings on immune-mediated mechanisms in lymphoid tissues linked with IBD pathogenesis and (potential) novel treatments. Enhanced innate and adaptive immune responses were observed in mesenteric lymph nodes (MLNs) and other lymphoid structures, such as Peyer’s patches, in patients with IBD and in animal models. Furthermore, the phenomenon of lymphatic obstruction in the form of granulomas in MLNs and lymphatic vessels correlates with disease activity. There is also evidence that abnormalities in the lymphatic stromal components and lymph node microbiome are common in IBD and could be exploited therapeutically. Finally, novel agents targeting lymphocyte trafficking have been added to the treatment armamentarium in the field of IBD. Overall, gut-associated lymphoid tissue plays a key role in IBD immunopathogenesis, which could offer novel therapeutic targets.     

一类椭圆变分不等式双侧障碍问题解的正则性

设 G是 n维欧几里得空间 En中的有界区域 ,令　 K ={u,u - u0 ∈ W1 ,p(G) ,φ1 (x)≥ u(x)≥φ2 (x) ,x∈ G}其中 u0 对任意的 x∈ G满足φ1 (x)≥ u0 (x)≥φ2 (x)。采用与以往不同的方法 ,研究了椭圆变分不等式　∫G{ (v - u) .A(x,u, u) (v - u) B(x,u, u) }dx≥ 0 , v∈ K在 A,B满足较为广泛的结构条件下 ,得到了其双侧障碍问题解的正则性 ,并推广、改进了 Mu J和 Zimer的主要结果 .     

穿甲弹异物阻滞膛炸机理数值仿真分析

以某穿甲弹近炮口处膛炸故障为背景,针对膛内存在异物时弹体和身管动态响应进行数值仿真,探讨膛炸机理并为故障分析与归零提供依据和参考。设定了两种典型异物阻滞形式：一是 异物阻滞造成弹体速度急剧下降或卡膛;二是弹体直接高速冲击膛内沙土类异物。采用有限元分析AUTODYN软件进行了多种不同工况数值计算,得到了弹体速度急剧下降时弹底燃气流场压力特征、身管变形与破裂形态,以及弹体高速冲击沙土类异物时结构动态响应、身管变形与破裂形态。研究结果表明：弹体膛内突然受阻和速度急剧下降,导致底部燃气中形成激波和局部高压区,局部高压区的存在可造成膛炸;弹体膛内近炮口处高速冲击沙土,身管受到复杂的强动载荷作用并可造成膛炸;数值仿真结果与实际故障情况相吻合并得到了故障复现试验的验证。     

Standardized MR protocol for the evaluation of MRA sequences and/or contrast agents effects in high-degree arterial stenosis analysis

Purpose To investigate the relative role of high resolution (spatial or temporal) magnetic resonance angiography (MRA) sequence and of contrast agent properties in the evaluation of high-degree arterial stenosis. Methods We qualitatively and quantitatively studied both 50 and 95% (300 μm diameter) stenosis of a 6 mm arterial phantom with two contrast agents (CA), Gd-DOTA (r₁ =2.9 mM⁻¹ s⁻¹) versus P760 (r₁ =25 mM⁻¹ s⁻¹) at several CA concentrations, including arterial peak concentration after injection of either a single or double dose of CA, using either a high temporal (booster) or high spatial (HR) resolution 3D MRA sequences. Experimental data were then compared to theoretical data. Results With the 3D HR sequence, both visual and quantitative analysis were significantly better compared to the 3D booster sequence, at each phantom diameter. Quantitative analysis was significantly improved by injection of a double versus a single dose of each CA (Gd-DOTA or P760), primarily in high degree stenosis. Conclusion Combined MRA spatial resolution and high CA efficiency are mandatory to correctly evaluate high degree stenosis.     

负载均衡技术在企业信息系统中的应用

针对企业信息系统在运行过程中出现阻塞的原因进行分析,得出通过负载均衡技术解决系统阻塞的结论,并对常见的几种负载均衡技术进行阐述和对比.