Fair‐Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration

Lipoxins (LXs) are autacoids, specialized proresolving lipid mediators (SPMs) acting locally in a paracrine or autocrine fashion. They belong to a complex superfamily of dietary small polyunsaturated fatty acid (PUFA)–metabolites, which direct potent cellular responses to resolve inflammation and restore tissue homeostasis. Together, these SPM activities have been intensely studied in systemic inflammation and acute injury or infection, but less is known about LX signaling and activities in the central nervous system. LXs are derived from arachidonic acid, an omega‐6 PUFA. In addition to well‐established roles in systemic inflammation resolution, they have increasingly become implicated in regulating neuroinflammatory and neurodegenerative processes. In particular, chronic inflammation plays a central role in Alzheimer's disease (AD) etiology, and dysregulated LX production and activities have been reported in a variety of AD rodent models and clinical tissue samples, yet with complex and sometimes conflicting results. In addition, reduced LX production following retinal injury has been reported recently by the authors, and an intriguing direct neuronal activity promoting survival and homeostasis in retinal and cortical neurons is demonstrated. Here, the authors review and clarify this growing literature and suggest new research directions to further elaborate the role of lipoxins in neurodegeneration.     

淤泥软基爆炸固结试验研究

对爆炸效应在淤泥软基工程中的应用问题进行了探讨，并首次提出了爆炸在淤泥软基中的分界应力特征以及排水固结及破坏分区的基本模式。为采用动力加速对淤泥软基工程的处理，提供了试验依据，具有实用价值和指导意义。     

利用黄河泥沙加固下游大堤

黄河是一条举世闻名的多泥沙河流，善淤、善决、善徒给沿河人民带来对过深重灾难，防洪问题一直是国家的心腹之患。泥沙问题是黄河防洪问题的症结所在。在总结固大堤经验的基础，进行挖河疏浚，淤筑“相对地下河”，已作为黄河治理的一项重大决策付诸实施。     

非饱和土的抗剪强度理论研究

从孔隙水的存在状态出发 ,围绕Bishop抗剪强度公式中存在的几个疑点展开讨论 .认为非饱和土中支配强度和变形的应力之所以不同 ,是因为非饱和土中存在一种性质与有效应力不同的应力———内部应力 ,它不传递 ,仅影响土的塑性变形 .同时还对Bishop ,Fredlund和卢肇钧提出的抗剪强度公式中的参数测试方法进行分析 ,指出 :各种抗剪强度理论在概念上都是相同的 ,其区别仅在于确定由吸力产生的那部分有效应力时采用的参数和测试方法不同     

压密注浆及其在地基加固中的应用

在简单介绍了压密注浆工法的加固机理、影响被加固土体强度的因素的基础上，结合工程实例介绍了压缩注浆工法的工程应用情况。     

饱和—非饱和土体非稳定渗流数值分析

本文对一般的非饱和渗流有限元计算方法加以改进，有效地消除了非饱和渗流数值计算中存在的数值弥散现象。同时还提出了一种简便有效的逸出面处理新方法，并给出了非饱和非稳定渗流计算的实例。     

一种带容性合并电路的外斜连MHD发电机

本文研究了有新颖容性合并电路的MHD发电机在法拉第联接下输出特性,指出由于新颖容性合并电路具有工作点可调性,在合理的参数匹配下有平稳的输出特性;从而提出了含补偿电源的容性合并电路和MHD发电机外斜连方案。该方案具有斜连发电机的特征,又具有法拉第发电机高焓取出的优点,而且可减小阴极导电渣对发电机寿命的影响,是一种有发展前景的功率调节器方案。     

Ultrasound‐activated Knoevenagel condensation of malononitrile with carbonylic compounds catalysed by alkaline‐doped saponites

α,β‐Unsaturated nitriles have been synthesized by Knoevenagel condensation of a carbonylic compound with malononitrile, assisted by sonochemical irradiation. Two alkaline‐promoted clays (Li⁺‐ and Cs⁺‐exchanged saponites) have been employed as catalysts. The influence of the carbonylic compound (benzaldehyde or cyclohexanone) and the use of a solvent on the catalytic activity have been studied. Remarkable increase in the conversion values has been found when the reaction is activated by ultrasound, as compared with the thermal activation. In this green, solvent‐free procedure, α,β‐unsaturated nitriles have been produced in very high yields (97%) when the Cs⁺‐saponite is used as catalyst. Copyright © 2004 Society of Chemical Industry     

Al-Cu-Fe QUASICRYSTALLINE PHASE FORMATION BY MECHANICAL ALLOYING

Al-Cu-Fe alloys were prepared from elemental powders in a high-energy planetary ball mill. A sequence of solid state reactions resulting in quasicrystal (QC) phase formation takes place during heating of the as-milled powder. These reactions were studied by both differential scanning calorimetry and x-ray diffraction methods. Mechanically alloyed powders were consolidated by cold and hot pressing, as well as by explosive compaction. After annealing at sufficiently high temperatures, the consolidated samples are single-phase QC, except the ones consolidated by explosion. The high reactivity of the as-milled alloys causes the appearance of high porosity of the consolidated samples after the annealing.     

纽柯公司2002年的运作及未来发展

介绍纽柯公司2002年的运作情况和做的几件大事：1)扩张与兼并；2)新工艺的采用；3)和外部的合作等。