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排序方式: 共有102条查询结果,搜索用时 1 毫秒
1.
近年来,各类视频应用上内容越来越丰富,页面上与当前用户无关的内容也越来越多。因此,市面上出现了多种不同的推荐算法来进行内容推荐。但是,不是每种推荐算法都能够解决所有的问题。基于个性化推荐系统的视频App,融合了多种推荐方法。首先为了解决推荐系统的冷启动问题,采用了基于统计学的推荐方式,同时,采用基于协同过滤的推荐算法,计算视频和用户间的隐藏特征,最后还有实时推荐模块,能够根据用户近期的行为对推荐内容进行调整。 相似文献
2.
Floodplain roughness parameterization using airborne laser scanning and spectral remote sensing 总被引:1,自引:0,他引:1
Floodplain roughness parameterization is one of the key elements of hydrodynamic modeling of river flow, which is directly linked to exceedance levels of the embankments of lowland fluvial areas. The present way of roughness mapping is based on manually delineated floodplain vegetation types, schematized as cylindrical elements of which the height (m) and the vertical density (the projected plant area in the direction of the flow per unit volume, m− 1) have to be assigned using a lookup table. This paper presents a novel method of automated roughness parameterization. It delivers a spatially distributed roughness parameterization in an entire floodplain by fusion of CASI multispectral data with airborne laser scanning (ALS) data. The method consists of three stages: (1) pre-processing of the raw data, (2) image segmentation of the fused data set and classification into the dominant land cover classes (KHAT = 0.78), (3) determination of hydrodynamic roughness characteristics for each land cover class separately. In stage three, a lookup table provides numerical values that enable roughness calculation for the classes water, sand, paved area, meadows and built-up area. For forest and herbaceous vegetation, ALS data enable spatially detailed analysis of vegetation height and density. The hydrodynamic vegetation density of forest is mapped using a calibrated regression model. Herbaceous vegetation cover is further subdivided in single trees and non-woody vegetation. Single trees were delineated using a novel iterative cluster merging method, and their height is predicted (R2 = 0.41, rse = 0.84 m). The vegetation density of single trees was determined in an identical way as for forest. Vegetation height and density of non-woody herbaceous vegetation were also determined using calibrated regression models. A 2D hydrodynamic model was applied with the results of this novel method, and compared with a traditional roughness parameterization approach. The modeling results showed that the new method is well able to provide accurate output data. The new method provides a faster, repeatable, and more accurate way of obtaining floodplain roughness, which enables regular updating of river flow models. 相似文献
3.
TAR DNA binding protein 43 (TDP-43) is a DNA/RNA binding protein involved in pivotal cellular functions, especially in RNA metabolism. Hyperphosphorylated and ubiquitinated TDP-43-positive neuronal cytoplasmic inclusions are identified in the brain and spinal cord in most cases of amyotrophic lateral sclerosis (ALS) and a substantial proportion of frontotemporal lobar degeneration (FTLD) cases. TDP-43 dysfunctions and cytoplasmic aggregation seem to be the central pathogenicity in ALS and FTLD. Therefore, unraveling both the physiological and pathological mechanisms of TDP-43 may enable the exploration of novel therapeutic strategies. This review highlights the current understanding of TDP-43 biology and pathology, describing the cellular processes involved in the pathogeneses of ALS and FTLD, such as post-translational modifications, RNA metabolism, liquid–liquid phase separation, proteolysis, and the potential prion-like propagation propensity of the TDP-43 inclusions. 相似文献
4.
Anna Shteinfer-Kuzmine Shirel Argueti-Ostrovsky Marcel F. Leyton-Jaimes Uttpal Anand Salah Abu-Hamad Ran Zalk Varda Shoshan-Barmatz Adrian Israelson 《International journal of molecular sciences》2022,23(17)
Impaired mitochondrial function has been proposed as a causative factor in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), caused by motor neuron degeneration. Mutations in superoxide dismutase (SOD1) cause ALS and SOD1 mutants were shown to interact with the voltage-dependent anion channel 1 (VDAC1), affecting its normal function. VDAC1 is a multi-functional channel located at the outer mitochondrial membrane that serves as a mitochondrial gatekeeper controlling metabolic and energetic crosstalk between mitochondria and the rest of the cell and it is a key player in mitochondria-mediated apoptosis. Previously, we showed that VDAC1 interacts with SOD1 and that the VDAC1-N-terminal-derived peptide prevented mutant SOD1 cytotoxic effects. In this study, using a peptide array, we identified the SOD1 sequence that interacts with VDAC1. Synthetic peptides generated from the identified VDAC1-binding sequences in SOD1 directly interacted with purified VDAC1. We also show that VDAC1 oligomerization increased in spinal cord mitochondria isolated from mutant SOD1G93A mice and rats. Thus, we used the novel VDAC1-specific small molecules, VBIT-4 and VBIT-12, inhibiting VDAC1 oligomerization and subsequently apoptosis and associated processes such as ROS production, and increased cytosolic Ca2+. VBIT-12 was able to rescue cell death induced by mutant SOD1 in neuronal cultures. Finally, although survival was not affected, VBIT-12 administration significantly improved muscle endurance in mutant SOD1G93A mice. Therefore, VBIT-12 may represent an attractive therapy for maintaining muscle function during the progression of ALS. 相似文献
5.
Cristina Porojan Simon M. Mitrovic Darren C. J. Yeo 《Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment》2016,33(10):1570-1586
Blue-green algae are responsible for the production of different types of toxins which can be neurotoxic, hepatotoxic, cytotoxic and dermatotoxic and that can affect both aquatic and terrestrial life. Since its discovery the neurotoxin β-methylamino-L-alanine (BMAA) has been a cause for concern, being associated with the neurodegenerative disease amyotrophic lateral sclerosis/Parkinsonism–dementia complex (ALS/PDC). The initial focus was on Guam where it was observed that a high number of people were affected by the ALS/PDC complex. Subsequently, researchers were surprised to find levels of BMAA in post mortem brains from Canadian patients who also suffered from ALS/PDC. Recent research demonstrates that BMAA has been found at different levels in the aquatic food web in the brackish waters of the Baltic Sea. There is emerging evidence to suggest that sand-borne algae from Qatar can also contain BMAA. Furthermore, there is now concern because BMAA has been found not only in warmer regions of the world but also in temperate regions like Europe. The aim of this review is to focus on the methods of extraction and analysis of the neurotoxic non-protein amino acid BMAA. We also consider the neurotoxicity, aetiology, and diverse sources and routes of exposure to BMAA. In recent years, different methods have been developed for the analysis of BMAA. Some of these use HPLC-FD, UPLC-UV, UPLC-MS and LC-MS/MS using samples that have been derivatised or underivatised. To date the LC-MS/MS approach is the most widely used analytical technique as it is the most selective and sensitive method for BMAA determination. 相似文献
6.
Extended HALS algorithm for nonnegative Tucker decomposition and its applications for multiway analysis and classification 总被引:1,自引:0,他引:1
Analysis of high dimensional data in modern applications, such as neuroscience, text mining, spectral analysis, chemometrices naturally requires tensor decomposition methods. The Tucker decompositions allow us to extract hidden factors (component matrices) with different dimension in each mode, and investigate interactions among various modalities. The alternating least squares (ALS) algorithms have been confirmed effective and efficient in most of tensor decompositions, especially Tucker with orthogonality constraints. However, for nonnegative Tucker decomposition (NTD), standard ALS algorithms suffer from unstable convergence properties, demand high computational cost for large scale problems due to matrix inverse, and often return suboptimal solutions. Moreover they are quite sensitive with respect to noise, and can be relatively slow in the special case when data are nearly collinear. In this paper, we propose a new algorithm for nonnegative Tucker decomposition based on constrained minimization of a set of local cost functions and hierarchical alternating least squares (HALS). The developed NTD-HALS algorithm sequentially updates components, hence avoids matrix inverse, and is suitable for large-scale problems. The proposed algorithm is also regularized with additional constraint terms such as sparseness, orthogonality, smoothness, and especially discriminant. Extensive experiments confirm the validity and higher performance of the developed algorithm in comparison with other existing algorithms. 相似文献
7.
Eukaryotic cells react to various stress conditions with the rapid formation of membrane-less organelles called stress granules (SGs). SGs form by multivalent interactions between RNAs and RNA-binding proteins and are believed to protect stalled translation initiation complexes from stress-induced degradation. SGs contain hundreds of different mRNAs and proteins, and their assembly and disassembly are tightly controlled by post-translational modifications. The ubiquitin system, which mediates the covalent modification of target proteins with the small protein ubiquitin (‘ubiquitylation’), has been implicated in different aspects of SG metabolism, but specific functions in SG turnover have only recently emerged. Here, we summarize the evidence for the presence of ubiquitylated proteins at SGs, review the functions of different components of the ubiquitin system in SG formation and clearance, and discuss the link between perturbed SG clearance and the pathogenesis of neurodegenerative disorders. We conclude that the ubiquitin system plays an important, medically relevant role in SG biology. 相似文献
8.
在语音信号处理的许多应用中,采用了无损音频压缩的方法.回顾了MPEG-4音频技术的现状,MPEG-4 ALS(Audio Lossless Coding)标准化过程以及编解码技术.详细介绍了编码器中的线性预测、量化、熵编码等模块,展望了MPEG-4 ALS的应用前景. 相似文献
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