交联透明质酸的降解及其释药性能

用己二酸二酰肼（ADH）对透明质酸（HA）进行化学修饰，制备交联透明质酸（HA-ADH）薄膜。粘度法测试表明HA-ADH是一种可降解的生物材料，并且与HA相比，HA．ADH的降解速率减慢。在此基础上，研究了以疏水性的替硝唑（TDZ）和亲水性的头孢唑啉钠（CEZ）为模拟药物的HA-ADH药物载体薄膜的释药性能。紫外-可见（UV-Vis）吸收光谱检测表明，HA-ADH是一种疏水性药物TDZ的优良缓释制荆，这是由于TDZ的疏水性和HA-ADH薄膜的缓慢溶胀和降解性能的结合而得到的，药物的释放主要受扩散机制控制。     

N-溴丁二酰亚胺／吡啶氧化合成己二酰基双偶氮化合物

以己二酰二氯和不同取代基的苯肼合成了N,N'-二芳基己二酰二肼类中间体,然后在N-溴丁二酰亚胺(NBS)／吡啶氧化体系下室温合成了8种己二酰基双偶氮化合物。第一步反应条件为:n(己二酰二氯):n(取代苯肼)=1:2,反应温度0-5℃,反应时间4 h,收率80%-93％;第二步反应条件为:n(N,N’-二芳基己二酰二肼):n(NBs／吡啶)=1:2,氧化反应时间0．5-1．0 h,收率80%-94%。并用元素分析、IR、1H NMR对合成的中间产物及目标化合物进行了表征。     

酮肼交联反应用于聚醋酸乙烯酯乳液改性

在制备低固含量的聚醋酸乙烯酯乳液的过程中,加入适量的双丙酮丙烯酰胺与醋酸乙烯酯共聚合,生成含有酮羰基的乳液,然后按照一定的比例加入己二酰肼,得到的乳液在使用时的脱水过程中酮羰基与肼发生交联反应,能够提高乳液的粘接强度和耐水性。     

酮肼交联对涂料印花用聚丙烯酸酯乳液的影响

以双丙酮丙烯酰胺(DAAM)作为官能单体,制备了含有酮羰基的聚丙烯酸酯乳液。将此乳液与己二酸二酰肼(ADH)混合,制得涂料印花用粘合剂。涂膜经红外光谱测试表明,乳液成膜时酮羰基与肼发生了交联反应。另外讨论了DAAM的用量与添加方式、DAAM与ADH的质量比以及固化温度等对织物印花各种性能的影响。     

室温交联丙烯酸乳胶漆的研制

对以双丙酮丙烯酰胺(DAAM)为交联单体,己二酰肼为固化剂制备室温交联丙烯酸乳胶漆进行了研究。采 用该交联体系,可显著提高涂膜的耐水性、耐溶剂性、光泽度及硬度,DAAM的用量以占总单体质量的6.5％为好。     

Synthesis and characterization of latexes based on copolymers BA\MMA\DAAM and BA\MMA\VEOVA-10\DAAM and the corresponding 1K crosslinkable binder using the adipic acid dihydrazide as crosslinking agent

In this study stable latexes of butyl acrylate (BA)/methyl methacrylate (MMA)/diacetone acrylamide (DAAM) copolymers and BA/MMA/vinyl neo-decanoate (VeoVa-10)/DAAM copolymers were synthesized by a modified semi-continuous microemulsion copolymerization. Ammonium persulfate was used as initiator and a redox system for post-polymerization to reduce the free monomers content. Methacrylic acid (MMA), 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylic acid (AA) and various “green” industrial anionic, non-ionic and anionic polymerizable surfactants free of alkylphenol ethoxylates (APEO free) were tested as a stabilizing system. The resulting latexes, their corresponding self-1K crosslinkable binder using the adipic acid (ADH) dihydrazide as crosslinking agent and their films were characterized with rotational viscometer, dynamic light scattering, gloss, dynamic mechanical analysis, minimum film forming temperature (MFFT), water resistance and swelling in methyl ethyl ketone measurements. The experiments showed that BA\MMA\VEOVA-10\DAAM latexes prepared with methacrylic acid and a polymerizable surfactant showed zero coagulation during polymerization. Their corresponding 1K crosslinkable binder with ADH were stable over 6 months storage time and showed good all around properties that makes them suitable for use in friendly to the environment coatings.     

Ionic liquid‐catalyzed aminolysis of poly(ethylene terephthalate) waste

Aminolytic depolymerization of poly(ethylene terephthalate) (PET) bottle waste with ethanolamine and hydrazine hydrate under atmospheric conditions was investigated in the presence of room temperature ionic liquids. 1‐Hexyl‐3‐methylimidazolium trifluoromethanesulfonate (Hmim.TfO) and 1‐butyl‐3‐methylimidazolium hydrogen sulfate (Bmim.HSO₄). (Hmim.TfO) was found to be the most efficient catalyst to obtain high yields of the aminolysis products bis(2‐hydroxy ethylene) terephthalamide and terephthalic dihydrazide using ethanolamine and hydrazine hydrate, respectively. These products were characterized by IR spectroscopy, ¹H NMR, ¹³C NMR, mass spectroscopy, and differential scanning calorimetry. The influence of experimental parameters, such as the amount of catalyst, reaction time, molar ratio of ethanolamine, and hydrazine hydrate with respect to PET was investigated. This protocol proves to be efficient and environmentally benign in terms of high yields (>84%) and low reaction times (up to 30 min). © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012     

草酸二酰肼在铝酸镧燃烧法合成中的应用

通过金属硝酸盐和草酸二酰肼氧化还原的事牧燃烧方法合成了钙钛矿型ＬａＡｌＯ３粉末，混合物在３５０℃着火燃烧后产物为非晶态，进一步在５００℃和６００℃焙烧后得到单相结晶的钙钛矿相。混合物的ＤＳＣ分析得知，混合物的着火起始温度为３４０℃。这种软化学方法的应用使钙钛矿型ＬａＡｌＯ３的合成温度达到了迄今为止的最低温度。     

改性咪唑的合成及其促进EP/己二酰肼固化体系的研究

以顺丁烯二酸作为2-乙基-4-甲基咪唑(EMI)的改性剂,合成出一种潜伏性促进剂——改性咪唑,并采用红外光谱(FT-IR)法对其结构进行了表征。以己二酰肼作为环氧树脂(EP)的固化剂,考察了改性咪唑对EP/己二酰肼胶粘剂的凝胶时间、固化特性、室温储存期和粘接性能等影响。结果表明:当w(改性咪唑)=1.5%时,改性咪唑对EP/己二酰肼体系具有较好的促进作用(体系放热温度下降了20℃左右);该胶粘剂的固化条件为"110℃/1 h→130℃/1 h",室温储存期超过60 d,并具有粘接性能优、耐水性能好等特点。     

酮肼交联反应在常温固化丙烯酸酯清漆制备中的应用

运用溶液聚合法合成了含有双丙酮丙烯酰胺(DAAM)单体的水溶性可常温固化的有机硅改性丙烯酸酯树脂,并添加一定量的中和剂三乙胺(TEA)、快干水(乙醇)、慢干水(丙二醇甲醚)、固化剂己二酸二酰肼(ADH)和助剂,利用酮肼交联反应,配制成丙烯酸酯清漆。考察了DAAM、ADH与TEA用量以及表干时间对漆膜性能、凝胶时间的影响,得出最佳条件为:DAAM用量控制在单体总质量的15.0%,DAAM与ADH的摩尔比为2∶1,表干时间45 min,中和度70%~80%。此时漆膜综合性能最好:光亮,硬度3H,附着力0级,耐水浸泡24 h完好,耐乙醇擦拭94次。