Role of Endocrine-Disrupting Chemicals in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: A Comprehensive Review

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required.     

Capture of Organic Vapors Using Adsorption and Electrothermal Regeneration

Activated-carbon-fiber cloth (ACFC) is an alternative adsorbent to granular activated carbon (GAC) for removing and recovering organic vapors from gas streams. Electrothermal desorption (ED) of ACFC provides rapid regeneration while requiring less energy compared to traditional regeneration techniques used with GAC. This paper provides proof-of-concept results from a bench-scale ACFC adsorption system. The automated system captured 1,000 ppmv of hazardous air pollutants/volatile organic compounds (HAPs/VOCs) from air streams and demonstrated the use of ED, using ac voltage, to recover the HAP/VOC as a pure liquid. The desorbed HAP/VOC condensed onto the inner walls of the adsorber and was collected at the bottom of the vessel, without the use of ancillary cooling. Seventy percent of the HAP/VOC was collected per cycle as condensate, with the balance being retained in the regenerated adsorber or recycled to the second adsorber. ED with in-vessel condensation results in minimal N2 consumption and short regeneration cycle times allowing the process to be cost competitive with conventional GAC-based adsorption processes. This technology extends the application of carbon adsorption systems to situations that were previously economically and physically impractical.     

明渠水流泥沙运动水深平均及力矩方程的理论和验证

首次提出了水流泥沙运动水深平均及其力矩方程的概念 ,并从理论上推导出这套方程组。提出水流泥沙运动力矩方程的目的有两个 ,一是在不增加空间维数的情况下可以有效地恢复水流泥沙因子沿水深分布信息 ,克服目前普遍使用的水深平均方程过多地忽略沿水深分布信息的缺点 ;二是增强模型的模拟能力。针对这两个目的是否能真正得到体现 ,分别从理论和实验室资料两个方面对新推导的力矩方程进行了全面的检验。理论验证结果表明 ,一维的力矩方程除了能模拟水深平均的流速和含沙量 ,还能够较好地模拟水流泥沙因子沿水深分布信息 ,这充分说明了一维力矩方程的二维特性。为了检验力矩方程的模拟能力 ,特别选取了一些极端的水流泥沙运动实验 ,如清水冲刷、点源加沙和深槽回淤等。模拟结果表明 ,力矩方程对于这些极端的水沙运动具有较好的模拟能力     

金刚烷最新研究

金刚烷是近 30年来发展起来的一种新型精细化工原料。简要介绍了金刚烷的分子结构、性质及其主要用途 ,重点对近年来国内外报道过的金刚烷合成方法进行了评述 ,在此基础上指出了金刚烷化工的未来发展趋势。     

基于数字CATV的超宽带技术研究

如何利用现有的数字CATV系统开展各种增值业务已成为一个重要课题.首先简要介绍了数字CATV和超宽带技术,然后给出了两种超宽带技术在现有数字CATV系统中的应用方案,利用这些方案可以有效地开展各项增值业务.     

关于建立纺织用染化料生态安全性评价体系的设想

从可持续发展战略和“绿色”、环保、生态等方面的需要提出关于建立纺织用染化料生态安全性评价体系的意义，并建议了列入安全性评价体系的项目及实施办法，同时也提出了需要解决的问题。     

分组交换网上的增值业务

本文介绍了公用和专用分组交换数据网的现状后，说明了开展标准的增值业务系统的重要性。论述了典型的增值业务系统－电子邮件和传真存储转发系统。     

溢流反弧段水流边界层有关概念的探讨

本文对溢流反孤段水流边界层的定义方法进行分析讨论。在分析及弧段流速分布的基础上提出离心力附加边界层厚度和粗糙度附加边界层厚度的概念,研究了壁面曲率和壁面粗糙度对溢流反弧段边界层发展的影响。     

卤水净化中储存加药方法的改进

制盐行业卤水净化都是采用库存药品和人工加药，这种做法劳动强度大，环境恶劣，影响人们健康，又不经济。为此介绍一种新的药品储存和投加工艺及设备。     

Artificial added mass instabilities in sequential staggered coupling of nonlinear structures and incompressible viscous flows

Within this paper the so-called artificial added mass effect is investigated which is responsible for devastating instabilities within sequentially staggered Fluid-structure Interaction (FSI) simulations where incompressible fluids are considered.A discrete representation of the added mass operator M_A is given and ‘instability conditions’ are evaluated for different temporal discretisation schemes. It is proven that for every sequentially staggered scheme and given spatial discretisation of a problem, a mass ratio between fluid and structural mass density can be found at which the coupled system becomes unstable. The analysis is quite general and does not depend upon the particular spatial discretisation schemes used. However here special attention is given to stabilised finite elements employed on the fluid partition. Numerical investigations further highlight the results.