Migraine: Calcium Channels and Glia

Migraine is a common neurological disease that affects about 11% of the adult population. The disease is divided into two main clinical subtypes: migraine with aura and migraine without aura. According to the neurovascular theory of migraine, the activation of the trigeminovascular system (TGVS) and the release of numerous neuropeptides, including calcitonin gene-related peptide (CGRP) are involved in headache pathogenesis. TGVS can be activated by cortical spreading depression (CSD), a phenomenon responsible for the aura. The mechanism of CSD, stemming in part from aberrant interactions between neurons and glia have been studied in models of familial hemiplegic migraine (FHM), a rare monogenic form of migraine with aura. The present review focuses on those interactions, especially as seen in FHM type 1, a variant of the disease caused by a mutation in CACNA1A, which encodes the α1A subunit of the P/Q-type voltage-gated calcium channel.     

豫西雷门沟钼矿水文地质条件分析及涌水量预测

豫西熊耳山雷门沟钼矿床位于东秦岭多金属成矿带东段,是已探明的超大型斑岩型钼矿,前人研究程度高、地质成果丰硕,但对矿床开采技术条件方面研究较少。本次通过地质调查工程、水文地质试验等方法,从水文地质角度,对雷门沟钼矿床水文地质条件进行研究,填补了该方面的空白,丰富了研究成果；采用水文地质比拟法预测未来矿坑最大排水量2613 m³/d,经实践检验结果较为可靠；总结的采坑排水量预测方法、含水层特点、矿床充水因素以及防治水措施,以期对该区域水文地质工作具有参考价值。     

Sleep Disorders Reduce Health-Related Quality of Life in Multiple Sclerosis (Nottingham Health Profile Data in Patients with Multiple Sclerosis)

Quality of Life (QoL) is decreased in multiple sclerosis (MS), but studies about the impact of sleep disorders (SD) on health-related quality of Life (HRQoL) are lacking. From our original cohort, a cross-sectional polysomnographic (PSG) study in consecutive MS patients, we retrospectively analysed the previously unpublished data of the Nottingham Health Profile (NHP). Those MS patients suffering from sleep disorders (n = 49) showed significantly lower HRQoL compared to MS patients without sleep disorders (n = 17). Subsequently, we classified the patients into four subgroups: insomnia (n = 17), restless-legs syndrome, periodic limb movement disorder and SD due to leg pain (n = 24), obstructive sleep apnea (n = 8) and patients without sleep disorder (n = 17). OSA and insomnia patients showed significantly higher NHP values and decreased HRQoL not only for the sleep subscale but also for the “energy” and “emotional” area of the NHP. In addition, OSA patients also showed increased NHP values in the “physical abilities” area. Interestingly, we did not find a correlation between the objective PSG parameters and the subjective sleep items of the NHP. However, this study demonstrates that sleep disorders can reduce HRQoL in MS patients and should be considered as an important confounder in all studies investigating HRQoL in MS.     

油层水洗级别的热解气相色谱定量判别

应用热解气相色谱资料开展水淹层评价是储层地球化学研究的一个新领域，目前，这方面的研究尚处于定性评价阶段。文章选择位于渤海湾盆地黄骅坳陷的港东油田和羊二庄油田新近系开发层系（包括馆陶组和明化镇组）为研究目的层，以岩心热解气相色谱分析为手段，开展了油层水洗级别的气相色谱定量判别的尝试。在系统分析各气相色谱参数的地质意义及其与油层水洗的关系的基础上，优选出合理的评价参数，并采用交会图技术建立不同级别水洗油层的定量判别标准，通过其他评价方法的验证，表明该定量判别方法具有实际应用价值。     

柯克亚油气田混合来源天然气的地球化学特征

柯克亚油气田是我国开发比较早的一个油气田,但由于受混源和其他因素的影响,对气源的认识众说纷纭。通过对天然气的地球化学特征的分析,并参照国内外关于甲烷、乙烷、丙烷碳同位素关系方面的资料,提出了如下看法:柯克亚天然气碳同位素相对较重,与塔里木盆地下古生界海相天然气的碳同位素组成区别较大;根据天然气40Ar/36Ar组成,柯克亚油气田的气源不是单一来源;柯克亚油气田绝大多数天然气的甲烷和乙烷碳同位素值关系符合Faber推断的 型有机质方程直线关系,说明有机质属于较好的有机质类型,或者是由原油裂解形成的天然气;除了K2井和K18井天然气成熟度较低以外,绝大多数天然气的成熟度大约在1.8%～2.2%之间,属于高过成熟气,但也混有一些成熟度在0.9%～1.2%的源岩形成的天然气;推测天然气主要来源于石炭系―二叠系源岩,而混有成熟度低的源岩形成的天然气则有可能来自侏罗系源岩。     

北部湾盆地福山凹陷CO2气成因探讨

北部湾盆地福山凹陷油气钻探中发现了高含CO₂气的天然气气藏。对CO₂气稳定碳同位素、伴生稀有气体氦和氩同位素进行了分析研究，结果显示，福山凹陷CO₂气稳定碳同位素偏重，(13C_CO2为-5.01～-10.08‰，绝大多数样品大于-7.0‰，为无机成因CO₂气特征；伴生稀有气体氦同位素³He/⁴He值为(4.74~5.03)×10^-6，R/Ra值为3.38～3.59；伴生稀有气体氩同位素⁴⁰Ar/³⁶Ar值为1881～2190，也显示出幔源或壳幔混合CO₂气的特征。综合判定认为，福山凹陷CO₂为壳幔混合成因。始新统流沙港组岩浆岩体分布特征与CO₂气藏分布范围基本一致，也表明幔源-岩浆可能是福山凹陷CO₂气的主要来源。与南海北部边缘盆地其它地区如珠江口盆地西部、琼东南盆地东部CO₂气成因一致，都为幔源-岩浆来源，或壳幔混合来源。     

泌阳凹陷复杂断块群油气分布控制因素

泌阳凹陷北部斜坡复杂断块群油田以断鼻、断块及断层+岩性油气藏为主,垂向含油层系多,平面上叠合连片,油气主要富集在鼻状构造主体部位的断鼻断块内。通过对研究区油气控制因素的分析,指出继承性的鼻状构造控制了油气聚集方向和富集程度,油气藏含油范围和油气藏高度则主要受断层封闭性和封闭程度的控制,油气分布规律受伸展构造所伴生的各种断块群构造型式的控制。     

Attentional Biases for Negative Interpersonal Stimuli in Clinical Depression.

An information-processing paradigm was used to examine attentional biases in clinically depressed participants, participants with generalized anxiety disorder (GAD), and nonpsychiatric control participants for faces expressing sadness, anger, and happiness. Faces were presented for 1,000 ms, at which point depressed participants had directed their attention selectively to depression-relevant (i.e., sad) faces. This attentional bias was specific to the emotion of sadness; the depressed participants did not exhibit attentional biases to the angry or happy faces. This bias was also specific to depression; at 1,000 ms, participants with GAD were not attending selectively to sad, happy, or anxiety-relevant (i.e., angry) faces. Implications of these findings for both the cognitive and the interpersonal functioning of depressed individuals are discussed and directions for future research are advanced. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

陆东凹陷油气藏烃类组成非均质性及其意义

陆东凹陷原油和油砂抽提物中烃类的宏观组成存在着明显的非均质性。在高孔隙度(>15%)储层单元中,饱和烃的含量高,占总组成的含量均大于40%,而极性化合物则相对较低,一般不足40%;相反,在低孔隙度(<15%)储层单元中,饱和烃的含量明显降低,而极性化合物则显著增加。此外,陆东凹陷原油和油砂抽提物中烃类成熟度亦存在着非均质性:在高孔隙度储层中,原油和油砂烃类的成熟度参数高,而在低孔隙度储层中原油和油砂烃类的成熟度参数低。根据原油和油砂抽提物中烃类的宏观组成特征和成熟度参数的变化规律,提出了陆东凹陷油气聚集模式。     

川西马井构造下白垩统含气性识别与评价

川西马进地区下白垩统含气性识别在测井解释上 ,主要在于储层含气水差异分辨较困难 ,气和水在测井曲线上的响应比较接近 ,过去解释的部分气层经测试却产水 ,常规的测井解释方法很难将二者区分开。以钻井录井显示和测试结果为依据 ,利用交会图分析技术 ,成功地对储层含气、水性质进行了识别 ;利用模糊聚类分析技术对含气性差异与含水性差异进行了判别。在此基础上 ,对含气性进行评价。