The Function of Sialidase Revealed by Sialidase Activity Imaging Probe

Sialidase cleaves sialic acid residues from glycans such as glycoproteins and glycolipids. In the brain, desorption of the sialic acid by sialidase is essential for synaptic plasticity, learning and memory and synaptic transmission. BTP3-Neu5Ac has been developed for sensitive imaging of sialidase enzyme activity in mammalian tissues. Sialidase activity in the rat hippocampus detected with BTP3-Neu5Ac increases rapidly by neuronal depolarization. It is presumed that an increased sialidase activity in conjunction with neural excitation is involved in the formation of the neural circuit for memory. Since sialidase inhibits the exocytosis of the excitatory neurotransmitter glutamate, the increased sialidase activity by neural excitation might play a role in the negative feedback mechanism against the glutamate release. Mammalian tissues other than the brain have also been stained with BTP3-Neu5Ac. On the basis of information on the sialidase activity imaging in the pancreas, it was found that sialidase inhibitor can be used as an anti-diabetic drug that can avoid hypoglycemia, a serious side effect of insulin secretagogues. In this review, we discuss the role of sialidase in the brain as well as in the pancreas and skin, as revealed by using a sialidase activity imaging probe. We also present the detection of influenza virus with BTP3-Neu5Ac and modification of BTP3-Neu5Ac.     

Nacre-Inspired,Liquid Metal-Based Ultrasensitive Electronic Skin by Spatially Regulated Cracking Strategy

The realization of liquid metal-based wearable systems will be a milestone toward high-performance, integrated electronic skin. However, despite the revolutionary progress achieved in many other components of electronic skin, liquid metal-based flexible sensors still suffer from poor sensitivity due to the insufficient resistance change of liquid metal to deformation. Herein, a nacre-inspired architecture composed of a biphasic pattern (liquid metal with Cr/Cu underlayer) as “bricks” and strain-sensitive Ag film as “mortar” is developed, which breaks the long-standing sensitivity bottleneck of liquid metal-based electronic skin. With 2 orders of magnitude of sensitivity amplification while maintaining wide (>85%) working range, for the first time, liquid metal-based strain sensors rival the state-of-art counterparts. This liquid metal composite features spatially regulated cracking behavior. On the one hand, hard Cr cells locally modulate the strain distribution, which avoids premature cut-through cracks and prolongs the defect propagation in the adjacent Ag film. On the other hand, the separated liquid metal cells prevent unfavorable continuous liquid-metal paths and create crack-free regions during strain. Demonstrated in diverse scenarios, the proposed design concept may spark more applications of ultrasensitive liquid metal-based electronic skins, and reveals a pathway for sensor development via crack engineering.     

三重介质油藏干扰试井压力动态特征

在建立三重介质油藏试井解释模型的基础上，对该类油藏的干扰试井压力动态变化进行了研究；分析了井筒储存、表皮系数、窜流系数以及弹性储容比对观测井井底压力的影响。结果表明，表皮系数对观测井的井底压力没有影响，而井筒储存是否会对观测井井底压力造成影响取决于井筒储存系数的大小以及激动井和观测井之间的距离，窜流系数和弹性储容比对观测井井底压力的影响与单井试井的结果相类似。     

红外热图技术在气功研究中的应用

本文用红外技术研究发功时上肢体表温度变化的特点和它的规律。     

银狐皮毛被及皮板组织构造的研究

用光学显微镜和扫描电镜观察了国产人工饲养银狐的毛被和皮板组织构造 ,测定了毛的长度、细度、密度、毛的鳞片高度和皮板厚度。提供了毛和皮板组织学图片 15幅。     

Modeling and Analysis of a Long Thin Conducting Stripline

A long thin conducting stripline embedded in a dielectric and centered between two large conducting plates, i.e., the stripline environment, is considered. The stripline is modeled as infinitely long, infinitely thin, and perfectly conducting by first considering a stripline of finite length, thickness, and conductivity in a dielectric layer. Starting from Maxwell's equations and assuming that the current on the stripline is a propagating wave in length direction, asymptotic expressions for the fields inside and in the neighbourhood of the stripline are deduced. These expressions are used to model the stripline in the stripline environment, which leads to a boundary-value problem for the electric potential. This problem is solved by two different approaches, leading to integral equations for the current and for an auxiliary function describing the electric potential. A relation between the current and the auxiliary function is deduced, which is used to obtain asymptotic expressions for current and impedance. Results are compared with a numerical solution of the integral equation for the current and with results in literature.     

新产品——钢带增强聚乙烯螺旋波纹管

钢带增强聚乙烯螺旋波纹管是一种创新的埋地排水管,把钢材的高刚度、高强度和聚乙烯的柔韧、耐腐结合在一起,突出的优点是环刚度高和节约原材料.     

井下伴热电缆导体集肤效应的有限元法分析

运用有限元法, 对交频井下伴热电缆导体内部的集肤效应现象进行了数值模拟和分析,比较直观地得出交频电缆中电流密度的分布特性, 以及交流电的不同频率对导体集肤深度的影响。在集肤效应作用下, 电缆导体内部的有效过流面积减小, 交流阻抗显著加大, 其发热量也很大,井下电缆伴热加热技术就是利用这一原理来加热原油的。通过数值模拟, 可以定量地说明电参数对加热效果的影响, 为稠油井井下电缆伴热技术中优化加热参数提供指导。     

可膨胀波纹管技术在韦15-19井的应用

可膨胀管包括可膨胀实体管和可膨胀波纹管，主要用于在不减小井眼尺寸的情况下封堵各种复杂地层，对损坏套管进行补贴修复，作为各种井筒封隔器以及延长技术套管长度。实体管和波纹管两者膨胀机理不一样，相比之下，可膨胀波纹管技术具有膨胀工艺简单，作业周期短的优点，该技术一直由俄罗斯掌握。中国石化勘探开发研究院经过多年的潜心研究，终于形成了具有自主知识产权的可膨胀波纹管产品及其配套的工艺技术，新研制的可膨胀波纹管壁厚8mm，抗内压强度35MPa，抗外挤强度10MPa，并在江苏油田韦15—19井进行了漏层封堵现场试验，经过扩眼、管串下入、水力膨胀、机械膨胀等工艺后获得圆满成功，标志着我国已经打破了国外公司对该技术的垄断，填补了国内在该领域的技术空白。