用于千兆以太网基带铜缆接收器均衡的甚高频自适应 连续时间Gm-C 二阶带通滤波器的研究和设计

本文设计了用于千兆以太网基带铜缆接收器均衡的甚高频自适应连续时间Gm-C二阶带通滤波器。基于最陡梯度下降算法，带通滤波器的零点在57－340MHz的频率范围内可以自适应地调节，中心频率为1.278GHz。通过外接电阻伺服环路，滤波器中跨导转换器的跨导值不受工艺偏差和温度变化的影响，采用CSMC－HJ0.6μm CMOS工艺器件模型，用Cadence Spectres仿真器仿真了设计的自适应滤波器电路，仿真结果验证了设计原理和设计的电路。系统的最长学习时间为880个参考时钟周期。     

超声波测距系统接收电路研究

介绍了超声波测距系统原理,针对超声波测距系统中常用的40 kHz超声波信号,提出了超声波接收电路设计原则,采用了集成运放OP27构成的同相放大器、仪表放大器、CX20106A红外接收芯片3种方案来检测超声波信号,设计了3种方法对应的接收电路,分析了各自的特点。     

简易超声波测距仪的制作

本系统利用AT89S51产生40kHz的频率驱动超声波换能器的发射头,接收头收到信号后,经CX20106A芯片进行放大、限幅、滤波、整形、比较后输出低电平送到单片机的外部中断0申请中断,单片机响应中断请求,取得定时器内的时间进行距离计算,用四位一体的数码管显示测出的距离,并可根据设定报警距离进行报警。制成的超声波测距仪性能良好,结构简单,达到了方便、快捷、准确地测量距离的目的,有较好的推广价值。     

Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia

Multiple lines of evidence support the pathogenic role of maternal immune activation (MIA) in the occurrence of the schizophrenia-like disturbances in offspring. While in the brain the homeostatic role of neuron-microglia protein systems is well documented, the participation of the CX3CL1-CX3CR1 and CD200-CD200R dyads in the adverse impact of MIA often goes under-recognized. Therefore, in the present study, we examined the effect of MIA induced by polyinosinic:polycytidylic acid (Poly I:C) on the CX3CL1-CX3CR1 and CD200-CD200R axes, microglial trajectory (MhcII, Cd40, iNos, Il-1β, Tnf-α, Il-6, Arg1, Igf-1, Tgf-β and Il-4), and schizophrenia-like behaviour in adult male offspring of Sprague-Dawley rats. Additionally, according to the “two-hit” hypothesis of schizophrenia, we evaluated the influence of acute challenge with Poly I:C in adult prenatally MIA-exposed animals on the above parameters. In the present study, MIA evoked by Poly I:C injection in the late period of gestation led to the appearance of schizophrenia-like disturbances in adult offspring. Our results revealed the deficits manifested as a diminished number of aggressive interactions, presence of depressive-like episodes, and increase of exploratory activity, as well as a dichotomy in the sensorimotor gating in the prepulse inhibition (PPI) test expressed as two behavioural phenotypes (MIA_PPI-low and MIA_PPI-high). Furthermore, in the offspring rats subjected to a prenatal challenge (i.e., MIA) we noticed the lack of modulation of behavioural changes after the additional acute immune stimulus (Poly I:C) in adulthood. The important finding reported in this article is that MIA affects the expression and levels of the neuron-microglia proteins in the frontal cortex and hippocampus of adult offspring. We found that the changes in the CX3CL1-CX3CR1 axis could affect microglial trajectory, including decreased hippocampal mRNA level of MhcII and elevated cortical expression of Igf-1 in the MIA_PPI-high animals and/or could cause the up-regulation of an inflammatory response (Il-6, Tnf-α, iNos) after the “second hit” in both examined brain regions and, at least in part, might differentiate behavioural disturbances in adult offspring. Consequently, the future effort to identify the biological background of these interactions in the Poly I:C-induced MIA model in Sprague-Dawley rats is desirable to unequivocally clarify this issue.     

A model for the structural dynamic response of the CX‐100 wind turbine blade

A geometrically exact beam model for simulating the structural dynamic response of the CX‐100 wind turbine blade is presented. The underlying geometrically nonlinear theory is detailed, and its implementation into a finite‐element code, NLBeam, developed as part of this research is outlined. The parameters used to represent the varying cross‐sectional distributions of stiffness and mass are calculated consistent with the geometrically exact beam theory by using the variational asymptotic method, as developed by Hodges and Yu et al. through the commercially available code, (VABS) variational asymptotic beam sectional analysis. Code and calculation verification are documented through a systematic grid convergence study applied independently to both the cross‐sectional, and static and dynamic beam simulations. An initial assessment of the model is made by comparing simulation results with experimental test data for three cases: quasistatic loading, linearized modal dynamic behavior and steady‐state oscillating dynamic loads. Simulation results are shown to be in reasonable agreement with experimental data. Future improvements to the model, as well as additional experimental characterization that can benefit such modeling efforts, are outlined. Copyright © 2013 John Wiley & Sons, Ltd.     

基于STC89C51单片机超声波测距系统的设计

介绍超声波测距原理和基于STC89C51单片机的超声波测距系统的组成、硬件结构和软件构成。从实验情况来看,该系统可靠性好、精度高。在设计中兼顾系统性能和器件成本的关系,降低整套系统的成本。     

三维叠前深度偏移在CX气田的应用

三维叠前深度偏移是解决复杂构造和速度横向变化剧烈地区地震资料成像问题的理想技术。应用三维叠前深度偏移成像技术,对CX气田的地震资料进行了三维叠前深度偏移处理,取得了良好的效果。其主要实现过程是:1在时间剖面上拾取速度层位,建立时间模型;2用相干反演法和叠加速度反演法相结合逐层求取层速度,建立层速度―深度地质模型;3用剩余速度分析修改和优化地质模型;4选用差分法实现三维叠前深度偏移。     

金融税控收款机系统中Modem的解决方案

介绍在金融税控收款机系统中Modem所应具有的同步/异步传输,高可靠兼容低速率及高速异步传输和支持快速握手协议的特点;详细介绍CX86500(Modem) CX20493(SmartDAA芯片)组成Modem方案的优点;说明CX86500 CX20493数据传输的硬件原理与软件实现。CX86500内部集成有MCU、DSP、RAM和ROM;外围元件很少,只需加入时钟与复位电路。用CX20493可以替代传统Modem方案中由模拟变压器、继电器和光电隔离器组成的DAA,有效地解决了POS行业Modem方案复杂的难题。     

高压气井CX488井天然气欠平衡压力钻井技术

新场构造沙溪庙组地层压力梯度高达0．015～O．018MPa／m，采用微超平衡压力钻井，在高密度钻井液条件下钻进，不但机械钻速低，还不利于发现和保护油气层。为此，在制定了详尽的完井方案、带压起下钻技术措施、岩屑分离方案和相关的应急措施后，CX488井在钻进沙溪庙组产层段时试验应用了天然气欠平衡压力钻井技术。试验结果表明，在高压地层采用天然气钻井技术可以大幅提高钻井速度，该井平均机械钻速达11．46m／h，与邻井相比机械钻速提高1倍以上。该技术在高压气井CX488井的成功应用为在高压地层应用气体钻井技术积累了经验。     

How miR-31-5p and miR-33a-5p Regulates SP1/CX43 Expression in Osteoarthritis Disease: Preliminary Insights

Osteoarthritis (OA) is a degenerative bone disease that involved micro and macro-environment of joints. To date, there are no radical curative treatments for OA and novel therapies are mandatory. Recent evidence suggests the role of miRNAs in OA progression. In our previous studies, we demonstrated the role of miR-31-5p and miR-33a families in different bone regeneration signaling. Here, we investigated the role of miR-31-5p and miR-33a-5p in OA progression. A different expression of miR-31-5p and miR-33a-5p into osteoblasts and chondrocytes isolated from joint tissues of OA patients classified in based on different Kellgren and Lawrence (KL) grading was highlighted; and through a bioinformatic approach the common miRNAs target Specificity proteins (Sp1) were identified. Sp1 regulates the expression of gap junction protein Connexin43 (Cx43), which in OA drives the modification of (i) osteoblasts and chondrocytes genes expression, (ii) joint inflammation cytokines releases and (iii) cell functions. Concerning this, thanks to gain and loss of function studies, the possible role of Sp1 as a modulator of CX43 expression through miR-31-5p and miR-33a-5p action was also evaluated. Finally, we hypothesize that both miRNAs cooperate to modulate the expression of SP1 in osteoblasts and chondrocytes and interfering, consequently, with CX43 expression, and they might be further investigated as new possible biomarkers for OA.