Fat Distribution and Lipid Profile of Young Adults with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Enzyme Deficiency

We aimed to compare detailed fat distribution and lipid profile between young adults with congenital adrenal hyperplasia due to 21-hydroxylase enzyme deficiency and a control group. We also verified independent associations of treatment duration and daily hydrocortisone dose equivalent (HDE) with lipid profile within patients. This case–control study included 23 patients (7 male and 16 female) matched by an age range of young adults (18–31 years) with 20 control subjects (8 male and 12 female). Dual energy X-ray absorptiometry was used to measure the fat distribution. Male patients demonstrated elevated indices of fat mass for total (7.7 ± 2.1 vs. 4.5 ± 1.3 kg/m², p = 0.003), trunk (4.0 ± 1.2 vs. 2.2 ± 0.8 kg/m², p = 0.005), android (0.63 ± 0.24 vs. 0.32 ± 0.15 kg/m², p = 0.008), gynoid (1.34 ± 0.43 vs. 0.74 ± 0.24 kg/m², p = 0.005), arm (0.65 ± 0.16 vs. 0.39 ± 0.10 kg/m², p = 0.009), and leg regions (2.7 ± 0.8 vs. 1.6 ± 0.4 kg/m², p = 0.005) than the control group, but not in females. However, female patients demonstrated elevated ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (1.90 ± 0.46 vs. 1.39 ± 0.47, p = 0.009) than the control group, but not in males. Total fat mass was inversely correlated with total testosterone (r = −0.64, p = 0.014) and positively correlated with leptin in males (r = 0.75, p = 0.002). An elevated daily HDE (β = 0.43, p = 0.038 and β = 0.47, p = 0.033) and trunk to total fat mass ratio (β = 0.46, p = 0.025, and β = 0.45, p = 0.037) were independently correlated with impaired lipid profile markers. Although there is no altered lipid profile, male patients demonstrated an increased fat distribution. However, female patients presented with an impaired lipid profile marker but demonstrated close values of normal fat distribution. Interestingly, the dose of glucocorticoid therapy can have some role in the lipid mechanisms.     

A design of experiments investigation into dry separation using a Knelson Concentrator

Enhanced gravity, or centrifugal, separators have revolutionised gold processing over the past decades, significantly increasing the recovery of fine (−100 μm) free gold. One of the main drawbacks of centrifugal gravity concentrators is the large volume of water required (even if it is all recycled). With water becoming an ever increasingly important “commodity”, reducing this is of importance both from an environmental and a monetary point of view. This work investigated operating a laboratory scale Knelson Concentrator with a dry feed and using air as the fluidising medium. The feed used was a synthetic mixture of tungsten and quartz, used to mimic a gold ore. The response surface method and central composite design techniques were used to design the experiments and to model the results, with the experimental variables being the bowl speed (G-Level), air fluidising pressure and the feed rate. The models corresponded well to the experimental results, indicating that for this experimental setup, the optimal conditions were a bowl G-Level of 40 G, a feed rate of 220 g/min and an air fluidising pressure of 8 psi.     

A multi-start central force optimization for global optimization

Central force optimization (CFO) is an efficient and powerful population-based intelligence algorithm for optimization problems. CFO is deterministic in nature, unlike the most widely used metaheuristics. CFO, however, is not completely free from the problems of premature convergence. One way to overcome local optimality is to utilize the multi-start strategy. By combining the respective advantages of CFO and the multi-start strategy, a multi-start central force optimization (MCFO) algorithm is proposed in this paper. The performance of the MCFO approach is evaluated on a comprehensive set of benchmark functions. The experimental results demonstrate that MCFO not only saves the computational cost, but also performs better than some state-of-the-art CFO algorithms. MCFO is also compared with representative evolutionary algorithms. The results show that MCFO is highly competitive, achieving promising performance.     

焊接试样的焊缝外形尺寸对爆炸试验的影响

选用水面舰艇用９４５钢和潜艇用９２１Ａ钢，研究了不同焊缝外形尺寸对爆炸试验中三缺口试样的中央缺口开裂行为的影响。通过大量的试验数据，确定了开裂判据ｅ≤ｅ_ｍ，为试验前预示中央缺口开裂与否提供了可靠的依据。     

城市中心区游憩功能的开发——以武汉市为例

从我国游憩空间建设实践中 ,概括出对城市游憩功能认识过程的四个阶段 .进而 ,从城市中心商业区、历史街区和城市滨水区三个方面讨论了城市中心区的游憩功能开发问题 .最后 ,以武汉市为例进行了分析     

户式中央空调发展方向的探讨

本文描述了我国户式中央空调的发展现状，分析了三种户式中央空调各自的特点，提出了把风管式机组作为我国户式中央空调的发展方向。     

浅析中央空调系统替代制冷剂的选择

根据大气臭氧层耗损和温室气体对全球气候变化的影响，分析了中央空调系统几种替代制冷剂的特性，探讨了在实际使用中如何进行替代制冷剂的选择。     

Effects of temperature, ammonium and glucose concentrations on yeast growth in a model wine system

In enology, alcoholic fermentation is a complex process involving several mechanisms. Slow and incomplete alcoholic fermentation is a chronic problem for the wine industry and factors leading to sluggish and stuck fermentations have been extensively studied and reviewed. The most studied cause of sluggish and stuck fermentation is the nitrogen content limitation. Nevertheless, other factors, such as temperature of fermentation and sugar concentration can affect the growth of yeasts. In this study we modelled the yeast growth‐cycle in wine model system as a function of temperature, sugar and ammonium concentrations; the individual effects and the interaction of these factors were analysed by means of a quadratic response surface methodology. Cell concentrations and weight loss were monitored in the whole wine fermentation process. The results of central composite design show that lower is the availability of nitrogen, higher is the cell growth rate; moreover, initial nitrogen concentration also influences survival time of Saccharomyces cerevisiae.     

中央空调系统变频节能改造方案

在我国经济快速发展的大背景下,能源（水、电、油）的消耗在企业中所占的比重越来越高,也受到愈来愈大的重视。同时也由于房地产的快速发展需求,中央空调的市场需求呈现强劲的增长。在市场容量不断增大的吸引下,越来越多的厂家加入到商用中央空调的领域。变频技术应用于中央空调系统,对提升中央空调自动化水平、降低能耗.减少对电网的冲击,延长机械及管网的使用寿命,都具有重要的意义。