基于椭圆曲线的KDM安全公钥加密方案

某些场合下敌手能够获取与私钥有关消息的密文,大多现有加密方案在上述情况下是不安全的。为抵抗这种攻击,给出一般子群不可区分困难假设的一个实例——椭圆曲线子群不可区分困难假设,并设计相应的归约算法。在此基础上,提出一个基于环 上椭圆曲线的公钥加密方案,并将该方案中的密文不可区分问题归约到椭圆曲线子群不可区分困难的假设上。分析结果证明,该方案在此假设下是安全的。     

Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring

Epigenetics play a vital role in early embryo development. Offspring conceived via assisted reproductive technologies (ARTs) have a three times higher risk of epigenetic diseases than naturally conceived children. However, investigations into ART-associated placental histone modifications or sex-stratified analyses of ART-associated histone modifications remain limited. In the current study, we carried out immunohistochemistry, chip-sequence analysis, and a series of in vitro experiments. Our results demonstrated that placentas from intra-cytoplasmic sperm injection (ICSI), but not in vitro fertilization (IVF), showed global tri-methylated-histone-H3-lysine-4 (H3K4me3) alteration compared to those from natural conception. However, for acetylated-histone-H3-lysine-9 (H3K9ac) and acetylated-histone-H3-lysine-27 (H3K27ac), no significant differences between groups could be found. Further, sex -stratified analysis found that, compared with the same-gender newborn cord blood mononuclear cell (CBMC) from natural conceptions, CBMC from ICSI-boys presented more genes with differentially enriched H3K4me3 (n = 198) than those from ICSI-girls (n = 79), IVF-girls (n = 5), and IVF-boys (n = 2). We also found that varying oxygen conditions, RNA polymerase II subunit A (Polr2A), and lysine demethylase 5A (KDM5A) regulated H3K4me3. These findings revealed a difference between IVF and ICSI and a difference between boys and girls in H3K4me3 modification, providing greater insight into ART-associated epigenetic alteration.     

基于DCR假设的KDM-CCA安全性

加密方案的KDM（Key-Dependent Message）安全性定义依赖于某一特定的函数族[F]。通过引入一类新的函数族,证明了在两个用户的情形下,Cramer和Shoup提出了基于DCR（Decisional Composite Residuosity）假设的方案（以下称为CS-DCR方案）,关于这类新函数族具有KDM-CCA安全性。由于CS-DCR方案本身非常得高效,因此,获得了兼有高效性和（相应）KDM-CCA安全性的加密方案。     

KDM4C Contributes to Trophoblast-like Stem Cell Conversion from Porcine-Induced Pluripotent Stem Cells (piPSCs) via Regulating CDX2

Studies on ESRRB-regulating porcine-induced pluripotent stem cells (piPSCs) converted to trophoblast-like stem cells (TLSCs) contribute to the understanding of early embryo development. However, the epigenetic modification regulation network during the conversion is poorly understood. Here, the global change in histone H3 Lysine 4, 9, 27, 36 methylation and Lysine 27 acetylation was investigated in piPSCs and TLSCs. We found a high modification profile of H3K36me2 in TLSCs compared to that of piPSCs, whereas the profiles of other modifications remained constant. KDM4C, a H3K36me3/2 demethylase, whose gene body region was combined with ESRRB, was upregulated in TLSCs. Moreover, KDM4 inhibitor supplementation rescued the AP-negative phenotype observed in TLSCs, confirming that KDM4C could regulate the pluripotency of TLSCs. Subsequently, KDM4C replenishment results show the significantly repressed proliferation and AP-positive staining of TLSCs. The expressions of CDX2 and KRT8 were also upregulated after KDM4C overexpression. In summary, these results show that KDM4C replaced the function of ESRRB. These findings reveal the unique and crucial role of KDM4C-mediated epigenetic chromatin modifications in determination of piPSCs’ fate and expand the understanding of the connection between piPSCs and TSCs.     

Knowledge Discovery Metamodel-ISO/IEC 19506: A standard to modernize legacy systems

Legacy systems age over time as a consequence of uncontrolled maintenance, thus they must be evolved while its valuable embedded knowledge is preserved. Software modernization, and particularly Architecture-Driven Modernization, has become the best solution in the legacy systems’ evolution. ADM defines the Knowledge Discovery Metamodel specification, now being adopted as ISO/IEC 19506 by the International Standards Organization. The KDM metamodel allows to represent all the software artifacts recovered during reverse engineering techniques at different abstraction levels. This paper presents how to use KDM to modernize legacy systems, making them more agile, preserving the embedded business knowledge and reducing maintenance costs.     

标准模型下KDM安全的对称加密方案

KDM(Key-Dependent Message)安全是考虑当加密的明文消息是所用加密方案私钥的函数时的安全问题。该文利用通用哈希函数(universal hash function),在标准模型下基于一种变形的剩余哈希引理(left-over hash lemma)构造出一个信息论KDM安全的无状态对称加密方案。该方案能够抵抗任意攻击者接近指数次边界的KDM加密询问攻击,并且攻击者询问的挑战函数可以是任意集合。最后通过合理选择参数,对比已有方案,证明该文所构造方案的安全性有所提高。     

数字影院系统中节目及密钥的安全机制及其实现过程

数字电影需要一定的安全机制来保护节目知识产权,DCI规范定义的数字影院系统采用AES加密节目,用数字证书技术、数字签名技术、RSA公钥技术保证节目密钥的安全传送,从而保证了数字电影节目的知识产权不受侵害。     

Histone Demethylase KDM7A Contributes to the Development of Hepatic Steatosis by Targeting Diacylglycerol Acyltransferase 2

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. While the development of NAFLD is correlated with aberrant histone methylation, modifiers of histone methylation involved in this event remain poorly understood. Here, we studied the functional role of the histone demethylase KDM7A in the development of hepatic steatosis. KDM7A overexpression in AML12 cells upregulated diacylglycerol acyltransferase 2 (DGAT2) expression and resulted in increased intracellular triglyceride (TG) accumulation. Conversely, KDM7A knockdown reduced DGAT2 expression and TG accumulation, and significantly reversed free fatty acids-induced TG accumulation. Additionally, adenovirus-mediated overexpression of KDM7A in mice resulted in hepatic steatosis, which was accompanied by increased expression of hepatic DGAT2. Furthermore, KDM7A overexpression decreased the enrichment of di-methylation of histone H3 lysine 9 (H3K9me2) and H3 lysine 27 (H3K27me2) on the promoter of DGAT2. Taken together, these results indicate that KDM7A overexpression induces hepatic steatosis through upregulation of DGAT2 by erasing H3K9me2 and H3K27me2 on the promoter.