Extracellular Vesicles and Asthma—More Than Just a Co-Existence

Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.     

单元串联式多电平高压变频器的起源、现状和展望

本文对单元串联式多电平高压变频器的起源和现状进行了总结,同时从无速度传感器矢量控制、大容量化、冗余设计等方面对该技术未来的发展趋势进行了展望。     

变频器的组成与常见故障及维修对策

本文介绍了变频器组成结构及相应故障与维修对策。     

基于IGBT的PWM大功率直流伺服驱动

本文介绍ＩＧＢＴ、ＥＸＢ８４１和ＬＥＭ模块在大功率ＰＷＭ直流伺服驱动系统中的应用和系统抗干扰设计。使用效果表明，基于ＩＧＢＴ的设计，可提高大功率直流伺服系统的可靠性和性能、减小体积、降低成本。     

连铸机中间罐车行走及升降机构的设计

阐述了中间罐车的设计要求及选型，较详细地分析了行走、升降机构的结构及设计。根据行走机构的特点，提出了２Ｋ－Ｈ型双速行星减速器的设计方法。     

一种悬臂式钢管喷印装置及其控制系统

本文介绍了一种用于成品钢管生产线上的悬臂式钢管喷印装置，它是一台结构和功能都较复杂的大型机电一体化设备。文中简介了它的性能、特点和工作原理，对其各部分机械装置的构成及动作以及喷印控制系统的组成和功能进行了较为深入的描述。     

步进电机在红外系统扫描机构中的应用

介绍了在红外系统中，采用步进电机作为扫描机构驱动元件，以Ｄ／Ａ数模转换器作细分方式的定频脉宽调制驱动方式，实现微机控制下的扫描机的构步距均匀稳定，满足红外系统分辨率的要求。     

128×128元IRCCD成像技术

研制成功了１２８×１２８元ＰｔｓｉＩＲＣＣＤ，获得了清晰的室温目标热像。文章叙述了该摄像机驱动逻辑电路的设计、驱动方式的研究和视频信号、数字信号的处理。     

CNC齿轮测量中心驱动控制与传动系统设计

描述了CNC齿轮测量中心的工作特点，着重介绍了测量中心驱动控制系统及机械进给系统的设计，并对机械传动系统的性能进行了分析，验算了主要设计参数。该测量机测量精度高，性能稳定，已开始小规模生产。     

Interactive fuzzy stochastic multi-level 0–1 programming using tabu search and probability maximization

In this paper, we consider interactive fuzzy programming for multi-level 0–1 programming problems involving random variable coefficients both in objective functions and constraints. Following the probability maximization model together with the concept of chance constraints, the formulated stochastic multi-level 0–1 programming problems are transformed into deterministic ones. Taking into account vagueness of judgments of the decision makers, we present interactive fuzzy programming. In the proposed interactive method, after determining the fuzzy goals of the decision makers at all levels, a satisfactory solution is derived efficiently by updating satisfactory levels of the decision makers with considerations of overall satisfactory balance among all levels. For solving the transformed deterministic problems efficiently, we also introduce novel tabu search for general 0–1 programming problems. A numerical example for a three-level 0–1 programming problem is provided to illustrate the proposed method.