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排序方式: 共有100条查询结果,搜索用时 31 毫秒
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Boshi Tian Shaohua Liu Chenghao Yu Shikai Liu Shuming Dong Lili Feng Narisu Hu Piaoping Yang 《Advanced functional materials》2023,33(25):2300818
As a less O2-dependent photodynamic therapy (PDT), type I PDT is an effective approach to overcome the hypoxia-induced low efficiency against solid tumors. However, the commonly used metal-involved agents suffer from the long-term biosafety concern. Herein, a metal-free type I photosensitizer, N-doped carbon dots/mesoporous silica nanoparticles (NCDs/MSN, ≈40 nm) nanohybrid with peroxidase (POD)-like activity for synergistic PDT and enzyme-activity treatment, is developed on gram scale via a facile one-pot strategy through mixing carbon source and silica precursor with the assistance of template. Benefiting from the narrow bandgap (1.92 eV) and good charge separation capacity of NCDs/MSN, upon 640 nm light irradiation, the excited electrons in the conduction band can effectively generate O2•− by reduction of dissolved O2 via a one-electron transfer process even under hypoxic conditions, inducing apoptosis of tumor cells. Moreover, the photoinduced O2•− can partially transform into more toxic •OH through a two-electron reduction. Moreover, the POD-like activity of NCDs/MSN can catalyze the endogenous H2O2 to •OH in the tumor microenvironment, further synergistically ablating 4T1 tumor cells. Therefore, a mass production way to synthesize a novel metal-free type I photosensitizer with enzyme-mimic activity for synergistic treatment of hypoxic tumors is provided, which exhibits promising clinical translation prospects. 相似文献
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Under water-rich conditions, small amphiphilic and hydrophobic drug molecules self-assemble into supramolecular nanostructures. Thus, substantial modifications in their interaction with cellular structures and the ability to reach intracellular targets could happen. Additionally, drug aggregates could be more toxic than the non-aggregated counterparts, or vice versa. Moreover, since self-aggregation reduces the number of effective “monomeric” molecules that interact with the target, the drug potency could be underestimated. In other cases, the activity could be ascribed to the non-aggregated molecule while it stems from its aggregates. Thus, drug self-assembly could mislead from drug throughput screening assays to advanced preclinical and clinical trials. Finally, aggregates could serve as crystallization nuclei. The impact that this phenomenon has on the biological performance of active compounds, the inconsistent and often controversial nature of the published data and the need for recommendations/guidelines as preamble of more harmonized research protocols to characterize drug self-aggregation were main motivations for this review. First, the key molecular and environmental parameters governing drug self-aggregation, the main drug families for which this phenomenon and the methods used for its characterization are described. Then, promising nanotechnology platforms investigated to prevent/control it towards a more efficient drug development process are briefly discussed. 相似文献
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Dynamic output feedback control of saturated switched delay systems under the PDT switching
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This paper is devoted to saturated control of switched delay systems. The main focus is to find a suitable switching law and saturated output feedback controllers such that the closed‐loop systems are asymptotically stable and have the disturbance tolerance/rejection capacity. A mixed slow/arbitrary switching approach, so‐called persistent dwell time (PDT) switching, is used to design the switching law. Compared with the slow switching, it is more general and leads to more flexibility in the process of constructing switching signals. More importantly, the proposed PDT is dependent on state delay, which includes the previous delay‐independent PDT. Next, time‐varying ellipsoids and a prescribe l2‐gain are introduced to characterize the disturbance tolerance and rejection capacities of systems, respectively. Based on the proposed results, the relation between delay‐dependent PDT and level of disturbance tolerance/rejection is shown. Finally, saturated controllers working in time‐varying hull controllable regions are designed. Thus, the considered problem is solved. An example is exploited to illustrate the effectiveness of the proposed results. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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差分吸收相干激光雷达中偏振分集技术研究 总被引:3,自引:3,他引:0
为减小差分吸收相干激光雷达(DIAL)中偏振衰落对 回波信号功率反演精度影响,研究了偏振分集技术(PDT)在相干DIAL中 的作用,构建了利用STM32控制的双光束切换DIAL实验装置。依托构 建的装置,利用平衡探 测,分别采用PDT和一般外差探测完成多组次实验,应用单频检测方法得到20m光程下吸收 气体不同浓度下相干中频信号的振 幅值,并由此求解出on光和off光回波信号功率。对回波信号功率值差分信息与由HITRAN得 到的参考差分信息比较 发现:应用PDT能使探测分辨率提高4倍,对应到2km距离内,可以探测到3.5×10-6ppm的CO2浓度变化,满足了 气候研究所需的优于1%的精度要求,验证了PDT消除偏振衰落以及提高相干DIAL分辨精度的 作用。 相似文献
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Ting Shang Cai-ding Wang Lei Ren Xin-hua Tian Dong-hui Li Xue-bin Ke Min Chen An-qi Yang 《Nanoscale research letters》2013,8(1):4
A near-infrared (NIR)-responsive Aurod@pNIPAAm-PEGMA nanogel was synthesized in two steps, growing a PEGMA monolayer on the surface of gold nanorods (AuNRs), followed by in situ polymerization and cross-linking of N-iso-propylacrylamide (NIPAAm) and poly-(ethylene glycol)-methacrylate (PEGMA). The AuNRs and Aurod@pNIPAAm-PEGMA nanogel were characterized by UV–vis spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy, respectively. The lower critical solution temperature of the Aurod@pNIPAAm-PEGMA nanogel could be tuned by changing the molar ratio of NIPAAm/PEGMA. The NIR-mediated drug release behavior of the Aurod@pNIPAAm-PEGMA nanogel was studied with zinc phthalocyanines (ZnPc4) as a drug model. It was also demonstrated that the loaded ZnPc4 could keep the capability of generating singlet oxygen, and the in vitro study showed a great photodynamic therapy (PDT) effect on Hela cells. It thus indicated the potential of this Aurod@pNIPAAm-PEGMA nanogel for application as a drug carrier in PDT, which might make contributions to oncotherapy. 相似文献
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目的 :通过细胞学水平研究确定ALA配合小剂量HPD激光光动力疗法促使肿细胞死亡及凋亡的光敏药用药剂量及与二者单独使用的差别方法 :以不同剂量的ALA(40 μg/ml、80 μg/ml、16 0 μg/ml)、HPD(2 .5 μg/ml、5 μg/ml、10 μg/ml)、二者联合与S180腹水瘤细胞一起培养 ,随后以 6 30nm半导体激光 2 0 0mW /cm2 ,照射肿瘤细胞 ,照射 2 0分钟 ,及与不用光敏剂单照激光、单用光敏剂不照光、不用光敏剂不照激光空白对照组比较。以流式细胞仪及倒置微镜观察促使肿瘤细胞凋亡或死亡的差别 ,寻找促使肿瘤细胞凋亡或死亡的最小合适剂量。结果 :ALA4 0 μg/ml配合HPD2 .5 μg/ml与S180腹水瘤细胞同时培养 ,6 30半导体激光 2 0 0mW /cm2 ,照射 2 0分钟组从形态学观察及流式细胞仪测定是能达到较佳的细胞凋亡的最小用光敏剂剂量。单纯ALA -PDT组中能达到小鼠S180腹水瘤细胞明显凋亡的最小剂量是ALA(80 μg/ml) ,单纯HPD -PDT组中能达到小鼠S180腹水瘤细胞明显凋亡最小剂量是HPD(5 μg/ml)。结论 :ALA4 0mg/kg配合HPD2 .5mg/kg ,6 30半导体激光2 0 0mW /cm2 ,照射 2 0分钟是能达到小鼠S180腹水瘤细胞明显凋亡的最小光敏剂剂量。 相似文献
9.
光动力疗法对肝癌小鼠的抗肿瘤及免疫效应研究 总被引:15,自引:0,他引:15
目的探讨光动力疗法(PDT)对肿瘤组织杀伤作用及免疫效应的机理。方法应用PDT对40只接种H22肝癌的昆明小鼠作杀伤实验,对组织形态学、抑瘤率及免疫学指标进行检测。结果PDT对肿瘤细胞具有选择性杀伤和抑制肿瘤组织生长的作用,激光照射5天与对照组瘤重分别为(0.760±0.613)g,(1.951±0.822)g;肿瘤体积为(1.648±0.683)cm3,(3.976±0.847)cm3,t=5.856,8.973,P<0.01,两组差异有非常显著性。对正常组织无损伤。各免疫指标与对照组差异有显著性。结论PDT具有直接杀伤癌细胞、抑制肿瘤组织生长的作用,并且对荷瘤小鼠的免疫功能有调节作用。 相似文献
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基于RFID和GPRS技术的城市物流配送系统研究 总被引:3,自引:0,他引:3
传统的城市物流配送系统普遍采用的PDT(Portable Data Terminal)虽然携带方便,但是却存在读写距离短、范围小,需要手工更新物流信息等不足.分析了传统城市物流配送系统中存在的一些缺点,提出了一种基于RFID(Radio Frequency Identification)和GPRS技术的城市物流配送系统框架,实现了大范围物流信息的采集、存储以及自动实时传输.详细分析了各组成部分主要功能及各子系统的具体实现. 相似文献