鸡蛋抗体的研究进展及其抗SARS病毒的可行性分析

鸡蛋抗体，即鸡卵黄中的免疫球蛋白，简称IgY。由于其具有不与人类补体结合，不与蛋白A结合以及不与类风湿因子结合等的免疫学特性，目前已被运用于疾病诊断检测和防治中。因此，利用IgY研制“非典”病毒特异性抗体，以用于预防“非典”病毒引起的呼吸道感染和治疗肺部感染及清除肠道中的病毒、防止排泄物引起的二次感染的设想有可能实现。本文就对鸡蛋抗体的研究进展及其抗SARS病毒的可行性作一分析、综述。     

弹载斜视FMCW-SAR的改进距离堆栈算法

分析了弹载斜视FMCW-SAR的成像几何关系,建立了其点目标回波信号模型和推导了回波信号的二维波数域形式.大斜视情况下,二次以上的高次距离方位耦合项不能忽略,所以FMCW-SAR中常用的改进频率变标算法不再适用.提出的距离堆栈改进算法在聚焦深度范围内利用相同的斜距值进行距离堆栈操作,其计算效率提高了2D2f*/( 1.57cλ)倍.与改进的频率变标算法相比,不同斜视角仿真实验的结果验证所提算法的有效性和正确性.     

Predictive factors of psychological disorder development during recovery following SARS outbreak.

Objective: To investigate strategies for broad mass isolation during outbreaks of infectious diseases. Design: A survey using a self-administered questionnaire was conducted on 300 printing company workers in Beijing, China, which was under mass isolation following the 2003 SARS outbreak, in the 7-8 months after the isolation was lifted. Main Outcome Measures: Individuals with psychological disorders were classified on the basis of scores on the 30-item General Health Questionnaire during the recovery period. Psychological disorders were observed in 49 of 187 respondents (26.2%; 95% CI = 20.2, 32.7). Results: The predicting factor with the highest correlation was income reduction, with an odds ratio of 25.0. Other items obtained were gender, range of activities, eating restrictions, restrictions in going out, disinfection of clothing, and infection control, with odds ratios of 3.2, 5.5, 3.9, 3.2, 0.2, and 0.1, respectively, and the contribution ratio was 87.7%. Conclusion: Securing income is suggested to be important in future strategies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Mechanistic Study of the Reaction of Thiol‐Containing Enzymes with α,β‐Unsaturated Carbonyl Substrates by Computation and Chemoassays

We investigated the reactions between substituted α,β‐unsaturated carbonyl compounds (Michael systems) and thiols by computations as well as chemoassays. The results give insight into variations in the underlying mechanisms as a function of the substitution pattern. This is of interest for the mechanisms of inhibition of the SARS coronavirus main protease (SARS‐CoV M^pro) by etacrynic acid derivatives as well as for the excess toxicity of substituted α,β‐unsaturated carbonyl compounds. This study compares possible reaction courses including 1,4‐addition followed by a ketonization step, and underscores the importance of a base‐catalyzed step for the reactivity of thiol groups in enzymes. Phenyl and methyl substituents at the Michael system decrease the reactivity of the electrophilic compound, but chlorophenyl substituents partly recover the reactivity. Computations also indicate that electron‐pushing substituents lead to a change in the reaction mechanism. The conformation of the Michael system is also found to significantly influence reactivity: the s‐cis conformation leads to higher reactivity than the s‐trans conformation. The computed data explain the trends in measured inhibition potencies of substituted α,β‐unsaturated carbonyl compounds and of reaction rates in chemical assays. They also indicate that the reversibility of inhibition does not stand in contrast to the formation of a new covalent bond between inhibitor and protease.     

用人工神经网络对SARS疫情进行分析与预测

采用三层结构的反向传播网络(backpropagationnetwork,简称BP网络),对SARS在中国的传播与流行趋势及控制策略建立了网络模型.并利用实际数据拟合参数,针对山西的疫情进行了计算仿真.结果表明,该网络模型算法收敛速度较快,预测精度很高.     

SARS风暴·从众心理·传媒责任

SARS风暴给生命健康带来严重威胁,但最大的影响是从众心理诱发的巨大恐慌.高度专制的封建社会是从众心理的历史根源;异常稳固的自然经济是从众心理的经济土壤;儒家独尊的文化格局是从众心理的思想温床;中国人的自身特点是从众心理的内质载体."科教兴国"战略是消除从众心理负面影响的有效途径,传媒对正确引导社会舆论有着不可推卸的责任.     

考虑自愈的SARS的传播模型

本文根据对SARS传播的分析,把人群分为5类:易感类、潜伏期类、患病未被发现类、患病已被发现类和治愈及死亡组成的免疫类,并考虑自愈因素,提出了两个模型:微分方程模型和基于SmallWorld Network的模拟模型.对微分方程模型,以香港为例讨论了自愈的影响,在一定意义下说明自愈现象在SARS传播中是普遍存在的.模拟模型利用Small-World Network[1]模拟现实中人们之间的接触;借鉴Sznajd模型[2]观念传播的基本思想"考察区域内每个成员如何影响与其有联系的其他成员",用影响类比传染,从患病者去传染与其有接触的健康人的角度,模拟SARS的传播过程;然后吸收元胞自动机模型[3]同步更新的思想,最终建立了一个患病者传染邻居,且一个成员同时受所有邻居影响的基于Small-WorldNetwork的模拟模型.对此模型,我们讨论了一些主要参数及接种疫苗的影响,最后拟合北京数据,讨论了提前或推迟5天采取措施的影响.