Activation of Nrf2/HO-1 by Peptide YD1 Attenuates Inflammatory Symptoms through Suppression of TLR4/MYyD88/NF-κB Signaling Cascade

In this study, we investigate the immunomodulatory effects of a novel antimicrobial peptide, YD1, isolated from Kimchi, in both in vitro and in vivo models. We establish that YD1 exerts its anti-inflammatory effects via up-regulation of the Nrf2 pathway, resulting in the production of HO-1, which suppresses activation of the NF-κB pathway, including the subsequent proinflammatory cytokines IL-1β, IL-6, and TNF-α. We also found that YD1 robustly suppresses nitric oxide (NO) and prostaglandin E2 (PGE₂) production by down-regulating the expression of the upstream genes, iNOS and COX-2, acting as a strong antioxidant. Collectively, YD1 exhibits vigorous anti-inflammatory and antioxidant activity, presenting it as an interesting potential therapeutic agent.     

UWinBatch配方管理软件在精细化工行业的应用研究

本文首先从核心理念、实现机理上对批量过程控制标准ISA S88进行了全面地解读分析,成功地将S88标准转换成了一个具体的产品--UWinBatch,然后以果汁生产线为例,对UWinBatch的开发过程、丰富的功能模块进行了介绍,最后在某公司的农药生产线项目应用中,以实际效果证明了UWinBatch是一款高度符合S88标准,能给用户带来极大收益的优秀产品。     

Adsorption and antibacterial effect of copper-exchanged montmorillonite on Escherichia coli K88

Calcium montmorillonite (Ca-MMT), sodium montmorillonite (Na-MMT) and acid-activated montmorillonite (AAM), and their Cu²⁺-exchanged montmorillonites (Cu-MMT), Cu*Ca-MMT, Cu*Na-MMT and Cu*AAM, were used to study the antibacterial activity on Escherichia coli K₈₈. AAM, Na-MMT and Ca-MMT showed some ability to reduce bacterial plate counts by 37.4%, 13.4% and 14.2%, respectively. Exchanging the montmorillonite with Cu²⁺ enhanced the antibacterial activity. The Cu*AAM, Cu*Na-MMT and Cu*Ca-MMT reduced the bacterial plate counts by 98.6%, 97.5% and 95.6%. Attempts were made to study the desorption of Cu²⁺ by washing with sterile physiological saline solution for 24 h. The washing solutions did not show a significant reduction of the bacterial counts, while the washed Cu-MMT retained their full antibacterial activity. Results from time-depending studies showed that the reduction of the bacterial counts by Cu-MMT increased during 24 h. The ranking of antibacterial activity of the three Cu-MMT was as Cu*AAM > Cu*Na-MMT > Cu*Ca-MMT. E. coli thrived optimally in a pH range from 5 to 7. Beyond this range, the bacterial counts decreased as the pH reduced the viability of the bacteria. The ranking of antibacterial activity of Cu-MMT was not affected by pH. The mechanism by which bacterial counts are reduced may involve the enhanced affinity of Cu-MMT for E. coli K₈₈ and the antibacterial activity of Cu²⁺.     

采用读卡机芯片FM1715SL设计的RFID读卡机

根据车辆管理系统对身份识别需求,提出基于国产芯片的RFID读卡机方案。数据接口设计为ISO14443TypeB的设备,在满足安全保密前提下,很好地兼顾了使用方便和高效便捷,大规模的车载应用验证了该方案的可靠性。     

USB主控制器在任意波发生器中的应用

研究和设计了嵌入式USB的主机系统,阐述了其工作机制,并给出了在任意波发生器控制面板上的具体实现,实现了改进波形数据输入方法的目的。首先研究了USB大容量存储类协议和USB主机在数据传输中的动作,然后根据任意波发生器的特点,利用SL811HS实现了USB主机功能,并在此基础上给出了USB存储设备的Bulk-In程序流程。     

适用于GEO卫星通信的单层重传机制

基于GEO卫星通信信道特性,分析现有LTE重传机制适应性改造所面临的问题,提出一种单层重传机制。该机制结合卫星链路时延大、信道质量较好的特点,去掉RLC层ARQ机制设计,并利用单层重传机制的通道数与RTD的相关性,通过扩展通道数及减少最大传输次数,提高现有重传机制对GEO卫星大时延信道特性的适应性。仿真结果表明,该重传机制能确保数据可靠性传输,缓解反馈信息带来的时延问题,提高系统吞吐量。     

基于DSP的自适应光纤/千兆网接口设计

本文以DSP芯片C6455为应用平台,介绍了一种自适应的光纤和网络接口通信设计方法。系统具有两个光纤和网络接口,可以自动识别所插入的设备,在不断电情况下可以任意交换接口,无须用户参与。文中详细介绍了该系统的软硬件设计方法。     

基于ATmega88的USART多处理机通信

单片机接口技术发展的一个趋势是：由并行外围总线接口向串行外围总线接口转变。USART全称是通用同步异步收发器,它是一种单片机外设模块,该资源常用于CPU与较远距离的设备进行通讯。USART接口可以用作同步传送或异步传送,是工业通信中的一种标准接口,而且USART串行接口外围扩展技术具有方便灵活、电路系统简单、占用I/O口资源少等特点。文章所实现的USART多处理机通信,通过地址和数据两种命令格式进行交互,此通信系统可以用作设备控制总线,方便灵活地控制外围设备。     

Quantifying requirements volatility effects

In an organization operating in the bancassurance sector we identified a low-risk IT subportfolio of 84 IT projects comprising together 16,500 function points, each project varying in size and duration, for which we were able to quantify its requirements volatility. This representative portfolio stems from a much larger portfolio of IT projects. We calculated the volatility from the function point countings that were available to us. These figures were aggregated into a requirements volatility benchmark. We found that maximum requirements volatility rates depend on size and duration, which refutes currently known industrial averages. For instance, a monthly growth rate of 5% is considered a critical failure factor, but in our low-risk portfolio we found more than 21% of successful projects with a volatility larger than 5%. We proposed a mathematical model taking size and duration into account that provides a maximum healthy volatility rate that is more in line with the reality of low-risk IT portfolios. Based on the model, we proposed a tolerance factor expressing the maximal volatility tolerance for a project or portfolio. For a low-risk portfolio its empirically found tolerance is apparently acceptable, and values exceeding this tolerance are used to trigger IT decision makers. We derived two volatility ratios from this model, the π-ratio and the ρ-ratio. These ratios express how close the volatility of a project has approached the danger zone when requirements volatility reaches a critical failure rate. The volatility data of a governmental IT portfolio were juxtaposed to our bancassurance benchmark, immediately exposing a problematic project, which was corroborated by its actual failure. When function points are less common, e.g. in the embedded industry, we used daily source code size measures and illustrated how to govern the volatility of a software product line of a hardware manufacturer. With the three real-world portfolios we illustrated that our results serve the purpose of an early warning system for projects that are bound to fail due to excessive volatility. Moreover, we developed essential requirements volatility metrics that belong on an IT governance dashboard and presented such a volatility dashboard.     

Robust model selection with flexible trimming

The forward search provides data-driven flexible trimming of a C_p statistic for the choice of regression models that reveals the effect of outliers on model selection. An informed robust model choice follows. Even in small samples, the statistic has a null distribution indistinguishable from an F distribution. Limits on acceptable values of the C_p statistic follow. Two examples of widely differing size are discussed. A powerful graphical tool is the generalized candlestick plot, which summarizes the information on all forward searches and on the choice of models. A comparison is made with the use of M-estimation in robust model choice.