跳时序列与跳频序列的性能比较

通过对传统通信中跳频序列与超宽带无线电通信中跳时序列的分析比较,得出了两者间相关性能的关系,论述了两者之间的差异,并总结出了将跳频序列转换成为跳时序列的方法,从而为超宽带无线电通信中跳时序列的构造提供了参考。     

膨胀管技术在西北油田TH10233CH井的应用

侧钻是降低油气开采成本的有效途径之一。西北油田受井眼尺寸、避水要求、不稳定泥岩、复杂压力体系等原因的影响,侧钻难度极大。为解决这一难题,在TH10233CH井采用膨胀管技术进行了实际应用。采用φ139.7mm膨胀管封固上部不稳定地层,膨胀管膨胀前内径124.2mm,膨胀后内径可达134.5mm,采用φ130mm钻头钻进,顺利完钻。膨胀管钻井技术在TH10233CH井的成功应用对西北油田侧钻井钻进具有重大指导意义。     

癌性腹水患者外周血TH1、TH2细胞免疫反应状态的研究

目的：研究辅助性T细胞（TH1、TH2）在癌性腹水患者中的作用及临床意义。方法：采用ELISA（酶联免疫吸附法）检测患者外周血和腹水中γ-干扰素（γ-INF）、白细胞介素（IL-4）水平,从而判断TH1、TH2细胞的活性。结果：癌性腹水患者外周血TH1细胞的活性较正常人明显降低,TH2细胞活性明显增强。治疗无效者外周血TH1细胞的活性进一步下降,TH2细胞活性进一步增强,而治疗有效者外周血TH1细胞功能逐渐增强,TH2细胞功能逐渐下降,其水平均接近于正常对照组。结论：外周血辅助性T细胞（TH1、TH2）的活性对癌性腹水患者的疗效及预后判断具有一定的价值。     

Antifreeze Proteins: Novel Applications and Navigation towards Their Clinical Application in Cryobanking

Antifreeze proteins (AFPs) or thermal hysteresis (TH) proteins are biomolecular gifts of nature to sustain life in extremely cold environments. This family of peptides, glycopeptides and proteins produced by diverse organisms including bacteria, yeast, insects and fish act by non-colligatively depressing the freezing temperature of the water below its melting point in a process termed thermal hysteresis which is then responsible for ice crystal equilibrium and inhibition of ice recrystallisation; the major cause of cell dehydration, membrane rupture and subsequent cryodamage. Scientists on the other hand have been exploring various substances as cryoprotectants. Some of the cryoprotectants in use include trehalose, dimethyl sulfoxide (DMSO), ethylene glycol (EG), sucrose, propylene glycol (PG) and glycerol but their extensive application is limited mostly by toxicity, thus fueling the quest for better cryoprotectants. Hence, extracting or synthesizing antifreeze protein and testing their cryoprotective activity has become a popular topic among researchers. Research concerning AFPs encompasses lots of effort ranging from understanding their sources and mechanism of action, extraction and purification/synthesis to structural elucidation with the aim of achieving better outcomes in cryopreservation. This review explores the potential clinical application of AFPs in the cryopreservation of different cells, tissues and organs. Here, we discuss novel approaches, identify research gaps and propose future research directions in the application of AFPs based on recent studies with the aim of achieving successful clinical and commercial use of AFPs in the future.     

Double beam near-infrared spectrometer for compensation of background water absorption and instrumental drift in intensity

A double beam near-infrared spectrometer is developed to compensate the water absorption and instrumental drift in intensity. The spectrometer may be used for both single and double beam measurements,and the two operation modes are compared. The results show that the double beam technique eliminates instrumental drift in the single beam measurement and therefore the stability of the system increases by more than 20%. The compensation of the double beam system on water absorption is verified by the measurement of fat content in milk. The results show that the spectrum data based on double beam mode get better calibration model and lower prediction error than traditional single beam mode.     

Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells

Loss of tolerance of the adaptive immune system towards indigenous flora contributes to the development of inflammatory bowel diseases (IBD). Defects in dendritic cell (DC)-mediated innate and adoptive immune responses are conceivable. The aim of this study was to investigate the expression of the inhibitory molecules CD200R1 and their ligand CD200 on DCs, to clarify the role of the DCs in the pathogenesis of IBD. Thirty-seven pediatric IBD patients (23 with Crohn’s disease (CD) and 14 with ulcerative colitis (UC)) with mean age 13.25 ± 2.9 years were included. Fourteen age-matched healthy pediatric volunteers (five males and nine females) served as a control group (HC). The percentage of CD11c⁺ myeloid dendritic cells (mDCs) and CD123⁺ plasmacytoid DCs (pDCs) expressing CD200R1 and CD200 were evaluated in peripheral blood using flow cytometry and were correlated with routine biochemical, serological markers, serum levels of cytokines and with the percentages of circulating regulatory T cells (Treg) and CD4⁺ producing IL-17 (Th17). IBD patients showed a significant decrease in the percentage of pDCs and mDCs expressing CD200R1 compared to that of HC. Patients with UC showed increased expressions of the CD200 molecule on pDCs as compared to HC. DCs expressing CD200R1 were found to be correlated positively with Treg and negatively with TH17 and erythrocyte sedimentation rate (ESR). Our findings suggest that IBD is associated with dysregulation in the CD200R1/CD200 axis and that the decrease in DCs expressing CD200R1 may contribute to the imbalance of Th17 and Treg cells and in the pathogenesis of IBD.     

Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish

Persistent organic pollutants (POPs) encompass an array of anthropogenic organic and elemental substances and their degradation and metabolic byproducts that have been found in the tissues of exposed animals, especially POPs categorized as organohalogen contaminants (OHCs). OHCs have been of concern in the circumpolar arctic for decades. For example, as a consequence of bioaccumulation and in some cases biomagnification of legacy (e.g., chlorinated PCBs, DDTs and CHLs) and emerging (e.g., brominated flame retardants (BFRs) and in particular polybrominated diphenyl ethers (PBDEs) and perfluorinated compounds (PFCs) including perfluorooctane sulfonate (PFOS) and perfluorooctanic acid (PFOA) found in Arctic biota and humans. Of high concern are the potential biological effects of these contaminants in exposed Arctic wildlife and fish. As concluded in the last review in 2004 for the Arctic Monitoring and Assessment Program (AMAP) on the effects of POPs in Arctic wildlife, prior to 1997, biological effects data were minimal and insufficient at any level of biological organization. The present review summarizes recent studies on biological effects in relation to OHC exposure, and attempts to assess known tissue/body compartment concentration data in the context of possible threshold levels of effects to evaluate the risks. This review concentrates mainly on post-2002, new OHC effects data in Arctic wildlife and fish, and is largely based on recently available effects data for populations of several top trophic level species, including seabirds (e.g., glaucous gull (Larus hyperboreus)), polar bears (Ursus maritimus), polar (Arctic) fox (Vulpes lagopus), and Arctic charr (Salvelinus alpinus), as well as semi-captive studies on sled dogs (Canis familiaris). Regardless, there remains a dearth of data on true contaminant exposure, cause-effect relationships with respect to these contaminant exposures in Arctic wildlife and fish. Indications of exposure effects are largely based on correlations between biomarker endpoints (e.g., biochemical processes related to the immune and endocrine system, pathological changes in tissues and reproduction and development) and tissue residue levels of OHCs (e.g., PCBs, DDTs, CHLs, PBDEs and in a few cases perfluorinated carboxylic acids (PFCAs) and perfluorinated sulfonates (PFSAs)). Some exceptions include semi-field studies on comparative contaminant effects of control and exposed cohorts of captive Greenland sled dogs, and performance studies mimicking environmentally relevant PCB concentrations in Arctic charr. Recent tissue concentrations in several arctic marine mammal species and populations exceed a general threshold level of concern of 1 part-per-million (ppm), but a clear evidence of a POP/OHC-related stress in these populations remains to be confirmed. There remains minimal evidence that OHCs are having widespread effects on the health of Arctic organisms, with the possible exception of East Greenland and Svalbard polar bears and Svalbard glaucous gulls. However, the true (if any real) effects of POPs in Arctic wildlife have to be put into the context of other environmental, ecological and physiological stressors (both anthropogenic and natural) that render an overall complex picture. For instance, seasonal changes in food intake and corresponding cycles of fattening and emaciation seen in Arctic animals can modify contaminant tissue distribution and toxicokinetics (contaminant deposition, metabolism and depuration). Also, other factors, including impact of climate change (seasonal ice and temperature changes, and connection to food web changes, nutrition, etc. in exposed biota), disease, species invasion and the connection to disease resistance will impact toxicant exposure. Overall, further research and better understanding of POP/OHC impact on animal performance in Arctic biota are recommended. Regardless, it could be argued that Arctic wildlife and fish at the highest potential risk of POP/OHC exposure and mediated effects are East Greenland, Svalbard and (West and South) Hudson Bay polar bears, Alaskan and Northern Norway killer whales, several species of gulls and other seabirds from the Svalbard area, Northern Norway, East Greenland, the Kara Sea and/or the Canadian central high Arctic, East Greenland ringed seal and a few populations of Arctic charr and Greenland shark.     

啤酒生产条件对酵母凝聚性的影响

本文规定了酵母凝聚性的测定方法,探讨了麦汁组成、发酵温度、pH值、酒精含量、发酵糖、无机离子、通风操作、污染菌、酵母代数和储存时间对酵母凝聚性的影响。     

塔河油田中半径水平井钻井液技术难点与对策

塔河油田中半径水平井存在直井段易缩径、三开井段井壁易坍塌、斜井段和水平段岩屑携带困难等技术难点，室内通过流型调节剂、防塌抑制剂和润滑剂的优选，开发出了性能优良的聚磺混油防塌钻井液体系，并制定了相应的现场施工技术措施。TK449H井、TH48—1井两口水平井的现场试验证明：聚磺混油防塌钻井液具有良好的防塌抑制性、流变性和润滑性，现场钻井液维护处理技术工艺合理、可操作性强；流变性控制理想，井眼清洁，携岩洗井效果好；试验井井壁稳定，井径较规则。聚磺混油防塌钻井液适合在该地区中半径水平井钻井中推广应用。     

TH系列防腐蚀涂料在炼油厂冷换设备上的应用

通过对炼油厂冷换设备腐蚀原因的分析 ,针对性地采用TH系列防腐蚀涂料 ,取得了良好的效果和经济效益 ,与涂刷前相比 ,设备使用寿命可由 2年延长到 6年。使用 10年来 ,其直接和间接经济效益达 6 70万元。