Vitamin D Compounds PRI-2191 and PRI-2205 Enhance Anastrozole Activity in Human Breast Cancer Models

1,25-Dihydroxycholecalciferol, the hormonally active vitamin D₃ metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the vitamin D active metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) and 1,25(OH)₂D₃ analog PRI-2205 was tested, and the in vitro activity of these analogs against different cancer cell lines was studied. We determined the effect of the two vitamin D compounds on anastrozole (An) activity against breast cancer based on antiproliferative activity, ELISA, flow cytometry, enzyme inhibition potency, PCR, and xenograft study. Both the vitamin D active metabolite and synthetic analog regulated the growth of not only estrogen receptor-positive cells (T47D and MCF-7, in vitro and in vivo), but also hormone-independent cancer cells such as SKBR-3 (HER-2-positive) and MDA-MB-231 (triple-negative), despite their relatively low VDR expression. Combined with An, PRI-2191 and PRI-2205 significantly inhibited the tumor growth of MCF-7 cells. Potentiation of the antitumor activity in combined treatment of MCF-7 tumor-bearing mice is related to the reduced activity of aromatase by both An (enzyme inhibition) and vitamin D compounds (switched off/decreased aromatase gene expression, decreased expression of other genes related to estrogen signaling) and by regulation of the expression of the estrogen receptor ERα and VDR.     

继电保护中多路模拟量采集系统的设计

介绍了一种基于高性能浮点DSP芯片TMS320C32、CPLD芯片XC95288和A/D采样芯片AD976组成的多路采集系统的工作原理以及设计方法。通过对第一路施加特殊的电压量,在CCS开发环境下读取采样缓冲区的值,并利用Matlab对采样数据进行了全波傅氏变换。此外,该系统已在继电保护中得到广泛应用,实践表明,该系统能较好地解决多路模拟量的采集,并确保了采样数据的安全可靠性。     

可编程模拟器件与技术新进展

简述可编程模拟器件的基本原理、典型应用和开发方法,介绍并比较主要的模拟可编程实现技术与主流器件系列,指出现存的主要问题并展望其未来发展方向.     

模拟信号的恢复及其误差研究

数模混合仿真中模拟信号的恢复及其误差对整个仿真过程具有重要影响。本文探讨了用零阶保持和一阶保持进行信号恢复的方法，比较了它们的误差及工作特点。特别指出了一阶保持中，由于存在积分器复原时间及数字机操作时间的影响而会带来附加的误差，因此一阶保持方法较难达到其理论的精度。     

Generation of Technology-Independent Retargetable Analog Blocks

This paper introduces a complete methodology for retargeting of analog cells to different sets of specifications. This methodology is technology-independent, thus allowing the migration, from one technology to another, of the circuit under retargeting. Careful integration of the device sizing and layout generation tasks via the incorporation of layout constraints during the sizing process allows to generate fully functional designs in a few minutes. The methodology is illustrated via the retargeting of a fully-differential Miller-compensated two-stage operational amplifier for a new set of specifications and two different technological processes.An erratum to this article can be found at     

一种动态开关电容运算放大器共模负反馈电路

本文主要介绍了一种应用于Cascode结构运放中的开关电容共模负反馈电路，它具有稳定性好、对运放频率特性影响小、不消耗额外功率等优点。对电路运用Hspice进行了模拟，并给出了模拟结果。     

Integrated Smart Sensor Calibration

In many applications electronic sensors are used toimprove performance and reliability of measurement systems. Suchsensors should provide a correct transfer from the physical signalto be measured to the electrical output signal. One importantstep to achieve this, is to calibrate each sensor by applyingdifferent reference input signals and adjusting the sensor transferaccordingly. Besides expensive reference equipment the calibrationprocess takes much time and attention per individual sensor,which means a considerable increase in sensor production costs.By including at the sensor or sensor interface chip a programmablecalibration facility the calibration of such smart sensors caneasily be automated and can be executed for a batch of sensorsat a time, thus minimizing the calibration time and costs. Thispaper presents a calibration method and options for integrationin the smart sensor concept, in hardware as well as in software.An advantage of the proposed method is that it does not needa large matrix of calibration data, which needs to be storedin a look-up table or converted into a correction formula, butinstead it uses a step-by-step approach to correct the sensortransfer at each calibration measurement until the error is sufficientlysmall.     

基于MOCCⅡ多功能滤波器的设计

本文简要介绍了Mulitple-output CCⅡ（简称MOCCⅡ）器件的电路特性，提出了一个新颖的基于MOCCⅡ多功能滤波器的电路。该电路可同时实现一阶低通以及二阶低通、高通、带阻、全通和带通等输出。经分析，该电路具有很低的灵敏度。电路中所有RC元件均接地，便于集成等优点。     

EWB应用于模拟电路分析的研究

介绍了将EWB用于“模拟电子技术”的课堂教学时，虚拟实验测量结果与理论计算值不一致时，如何去分析并解决问题。     

微波功率放大器预失真线性化技术分析

给出了两种基本形式的预失真线性化电路,对其工作原理和技术特点进行了分析。