Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature

Cerebral microbleeds (CMBs) are small hemosiderin deposits indicative of prior cerebral microscopic hemorrhage and previously thought to be clinically silent. Recent population‐based cross‐sectional studies and prospective longitudinal cohort studies have revealed association between CMB and cognitive dysfunction. In the general population, CMBs are associated with age, hypertension, and cerebral amyloid angiopathy. In the chronic kidney disease (CKD) population, diminished estimated glomerular filtration rate has been found to be an independent risk factor for CMB, raising the possibility that a uremic milieu may predispose to microbleeds. In the end‐stage renal disease (ESRD) population on hemodialysis, the incidence of microbleeds is significantly higher compared with a control group without history of CKD or stroke. We present an ESRD patient on chronic hemodialysis with a history of gradual cognitive decline and progressive CMBs. Through this case and literature review, we illustrate the need to develop detection and prediction models to treat this frequent development in ESRD patients.     

Skeletal Muscle Health and Cognitive Function: A Narrative Review

Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and reduced neurological drive. Cognitive decline refers to diminished or impaired mental and/or intellectual functioning. Contracting skeletal muscle is a major source of neurotrophic factors, including brain-derived neurotrophic factor, which regulate synapses in the brain. Furthermore, skeletal muscle activity has important immune and redox effects that modify brain function and reduce muscle catabolism. The identification of common risk factors and underlying mechanisms for sarcopenia and cognition may allow the development of targeted interventions that slow or reverse sarcopenia and also certain forms of cognitive decline. However, the links between cognition and skeletal muscle have not been elucidated fully. This review provides a critical appraisal of the literature on the relationship between skeletal muscle health and cognition. The literature suggests that sarcopenia and cognitive decline share pathophysiological pathways. Ageing plays a role in both skeletal muscle deterioration and cognitive decline. Furthermore, lifestyle risk factors, such as physical inactivity, poor diet and smoking, are common to both disorders, so their potential role in the muscle–brain relationship warrants investigation.     

蜡晶形态结构对原油降凝的影响

 采用偏光显微镜观察了不同条件下蜡晶的形态变化，对蜡结晶过程中的结构、分布状态和生长规律进行了深入的研究，采用气相色谱分析了用52#、62#、80#蜡配制的模拟油中蜡的碳数分布，考察了凝点与蜡含量之间的变化规律，以及沥青质、胶质和大分子降凝剂(PPD)对模拟油降凝、降粘的影响，为改善原油流动性提供理论依据。实验结果表明，蜡晶的微观形态结构、蜡在油中的溶解性能以及降凝剂的降凝作用与模拟油中蜡的碳数分布密切相关，只有当降凝剂分子结构与油中蜡的结构匹配时，才能达到理想的降凝效果。通过实验确定了模拟油降凝时的临界蜡含量为40%（质量分数），大于该临界值后，凝点随着蜡含量的变化幅度将大大降低。     

一种新型递减曲线的简单求法与应用

通过对油气藏产量递减的研究、线性最优化方法的分析研究及文献[1]提出的这种新型递减曲线的研究，提出了解这种方程的一个简单求法。通过现场的实例应用表明：提出的方法具有简单、方便、方法可靠的优点。采用此方法时，产量不以年为单位而是以月为单位进行计算，这将使计算更准确、更合理。     

输油管线停输期间开泵顶管时间周期的确定

对于间断性输送高凝点石油产品 ,在停输时间较长的情况下 ,为避免油品凝结 ,需定时开泵进行顶管。为减少操作频次 ,节约能量消耗 ,通过对管线油品温降的计算和分析 ,可以比较精确地测算出输油管线温降规律 ,从而确定停输期间开泵顶管的时间周期 ,为生产实际提供理论依据     

产量递减规律的诊断方法

传统的Arps产量递减分析方法要求事先选定递减规律的初始时间、初始产量及初始递减率,事实上这些参数是很难确定的。实际应用时不得不人为地加以臆断而使得此方法带有不确定性.为此提出了产量递减规律的诊断方法。应用诊断曲线很容易确定递减规律的模型参数,克服常规方法的不足。通过选用参考时间、参考产量和参考递减率,使得递减分析方法具有一定的灵活性和优越性、该方法简便、实用。     

�ݼ����߷����������Ϸ�

通过对J.J.Arps方程的推导,提出了油气藏产量递减曲线分析的最佳拟合法。用该法可直接求出递减指数N、初始递减率D1及油气递减前的稳定产量Qi,避免了使用试差法的大量运算过程,大大提高了油气藏工程中指标预测的精度。     

新区采油速度与稳产时间、递减率变化关系研究

针对新区稳产时间以及递减期递减余率大小难以确定等问题,通过对中原油田61个独立小区块进行分析对比,得出采油速度与稳产时间,不同采油速度下无因次采油速度与时间关系曲线,对于新区开发预测稳产时间以及预测递减期产量变化有着重要意义.     

衰减曲线分析的诺模图

基于Arps递减方程,建立了衰减曲线分析的诺模图。应用该诺模图,可以方便地确定油气田的可采储量。     

致密油藏直井多层缝网压裂产量递减分析

垂向多层发育的致密油藏常采用缝网压裂进行开采,从而改善储层渗透率,提高油井产量。为此建立直井多层缝网压裂不稳定渗流数学模型,压裂后各层划分为人工裂缝区、改造区和未改造区。绘制分析Blasingame产量递减典型曲线,曲线分为7个流动阶段,总裂缝长度一定时,裂缝半长短的储层流体渗流率先到达未改造区,流体渗流阻力大,Blasingame曲线靠下;总改造体积一定时,各层改造体积差异越大,Blasingame曲线越靠下。用所建立的模型,对实测生产资料进行解释,获得各层裂缝半长、改造区渗透率等相关地层参数,该模型对进行多层缝网压裂直井产量分析具有指导意义。