全文获取类型
收费全文 | 253篇 |
免费 | 12篇 |
国内免费 | 19篇 |
专业分类
电工技术 | 2篇 |
综合类 | 6篇 |
化学工业 | 152篇 |
金属工艺 | 12篇 |
机械仪表 | 6篇 |
建筑科学 | 12篇 |
轻工业 | 5篇 |
无线电 | 13篇 |
一般工业技术 | 17篇 |
冶金工业 | 30篇 |
原子能技术 | 1篇 |
自动化技术 | 28篇 |
出版年
2023年 | 8篇 |
2022年 | 82篇 |
2021年 | 61篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 8篇 |
2017年 | 10篇 |
2016年 | 4篇 |
2015年 | 4篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 3篇 |
2011年 | 8篇 |
2010年 | 10篇 |
2009年 | 3篇 |
2008年 | 3篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 13篇 |
2004年 | 6篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 3篇 |
1997年 | 1篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有284条查询结果,搜索用时 15 毫秒
1.
Jan H. Dring Julian Schrter Jerome Jüngling Saskia Biskup Kerstin A. Klotz Thomas Bast Tobias Dietel G. Christoph Korenke Sophie Christoph Heiko Brennenstuhl Guido Rubboli Rikke S. Mller Gaetan Lesca Yves Chaix Stefan Klker Georg F. Hoffmann Johannes R. Lemke Steffen Syrbe 《International journal of molecular sciences》2021,22(6)
Pathogenic variants in KCNA2, encoding for the voltage-gated potassium channel Kv1.2, have been identified as the cause for an evolving spectrum of neurological disorders. Affected individuals show early-onset developmental and epileptic encephalopathy, intellectual disability, and movement disorders resulting from cerebellar dysfunction. In addition, individuals with a milder course of epilepsy, complicated hereditary spastic paraplegia, and episodic ataxia have been reported. By analyzing phenotypic, functional, and genetic data from published reports and novel cases, we refine and further delineate phenotypic as well as functional subgroups of KCNA2-associated disorders. Carriers of variants, leading to complex and mixed channel dysfunction that are associated with a gain- and loss-of-potassium conductance, more often show early developmental abnormalities and an earlier onset of epilepsy compared to individuals with variants resulting in loss- or gain-of-function. We describe seven additional individuals harboring three known and the novel KCNA2 variants p.(Pro407Ala) and p.(Tyr417Cys). The location of variants reported here highlights the importance of the proline(405)–valine(406)–proline(407) (PVP) motif in transmembrane domain S6 as a mutational hotspot. A novel case of self-limited infantile seizures suggests a continuous clinical spectrum of KCNA2-related disorders. Our study provides further insights into the clinical spectrum, genotype–phenotype correlation, variability, and predicted functional impact of KCNA2 variants. 相似文献
2.
Dr. Daisuke Okuno Dr. Noriho Sakamoto Dr. Mohammed S. O. Tagod Yoshiko Akiyama Dr. Sakiko Moriyama Dr. Takuto Miyamura Dr. Atsuko Hara Dr. Takashi Kido Dr. Hiroshi Ishimoto Prof. Yuji Ishimatsu Prof. Takashi Tanaka Prof. Jun Ishihara Prof. Kohsuke Takeda Prof. Yoshimasa Tanaka Prof. Hiroshi Mukae 《ChemMedChem》2021,16(16):2515-2523
Heat shock protein 47 (HSP47), a collagen-specific molecular chaperone, is causally related to fibrotic diseases, including idiopathic pulmonary fibrosis. The identification of Compounds that interfere with the HSP47-collagen interaction is essential for the development of relevant therapeutics. Herein, we prepared human HSP47 as a soluble fusion protein expressed in E. coli and established an assay system for HSP47 inhibitor screening. We screened a natural and synthetic Compound library established at Nagasaki University. Among 1023 Compounds, 13 exhibited inhibitory activity against human HSP47, of which three inhibited its function in a dose-dependent manner. Epigallocatechin-3-O-gallate, one of these three Compounds, is a typical polyphenol Compound derived from tea leaves. Structurally related Compounds were synthesized and examined for their activity, revealing a hydroxyl group at A-ring position 5 as important for its activity. The present findings provide valuable insight for the development of natural product-derived therapeutics for fibrotic diseases, including idiopathic pulmonary fibrosis. 相似文献
3.
Gaku Yamanaka Shinichiro Morichi Tomoko Takamatsu Yusuke Watanabe Shinji Suzuki Yu Ishida Shingo Oana Takashi Yamazaki Fuyuko Takata Hisashi Kawashima 《International journal of molecular sciences》2021,22(9)
Accumulating evidence has demonstrated that the pathogenesis of epilepsy is linked to neuroinflammation and cerebrovascular dysfunction. Peripheral immune cell invasion into the brain, along with these responses, is implicitly involved in epilepsy. This review explored the current literature on the association between the peripheral and central nervous systems in the pathogenesis of epilepsy, and highlights novel research directions for therapeutic interventions targeting these reactions. Previous experimental and human studies have demonstrated the activation of the innate and adaptive immune responses in the brain. The time required for monocytes (responsible for innate immunity) and T cells (involved in acquired immunity) to invade the central nervous system after a seizure varies. Moreover, the time between the leakage associated with blood–brain barrier (BBB) failure and the infiltration of these cells varies. This suggests that cell infiltration is not merely a secondary disruptive event associated with BBB failure, but also a non-disruptive event facilitated by various mediators produced by the neurovascular unit consisting of neurons, perivascular astrocytes, microglia, pericytes, and endothelial cells. Moreover, genetic manipulation has enabled the differentiation between peripheral monocytes and resident microglia, which was previously considered difficult. Thus, the evidence suggests that peripheral monocytes may contribute to the pathogenesis of seizures. 相似文献
4.
5.
6.
7.
Classification of focal and nonfocal EEG signals using ANFIS classifier for epilepsy detection
下载免费PDF全文
![点击此处可从《International journal of imaging systems and technology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
S. Deivasigamani C. Senthilpari Wong Hin Yong 《International journal of imaging systems and technology》2016,26(4):277-283
The electroencephalogram (EEG) is the frequently used signal to detect epileptic seizures in the brain. For a successful epilepsy surgery, it is very essential to localize epileptogenic area in the brain. The signals from the epileptogenic area are focal signals and signals from other area of the brain region nonfocal signals. Hence, the classification of focal and nonfocal signals is important for locating the epileptogenic area for epilepsy surgery. In this article, we present a computer aided automatic detection and classification method for focal and nonfocal EEG signal. The EEG signal is decomposed by Dual Tree Complex Wavelet Transform (DT‐CWT) and the features are computed from the decomposed coefficients. These features are trained and classified using Adaptive Neuro Fuzzy Inference System (ANFIS) classifier. The proposed system achieves 98% sensitivity, 100% specificity, and 99% accuracy for EEG signal classification. The experimental results are presented to show the effectiveness of the proposed classification method to classify the focal and nonfocal EEG signals. © 2016 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 26, 277–283, 2016 相似文献
8.
9.
10.
Incisa della Rocchetta A.; Samson S.; Ehrlé N.; Denos M.; Hasboun D.; Baulac M. 《Canadian Metallurgical Quarterly》2004,18(1):15
This study addressed the role of the medial temporal lobe regions and, more specifically, the contribution of the human hippocampus in memory for body-centered (egocentric) and environment-centered (allocentric) spatial location. Twenty-one patients with unilateral atrophy of the hippocampus secondary to long-standing epilepsy (left, n = 7; right, n = 14) and 15 normal control participants underwent 3 tasks measuring recall of egocentric or allocentric spatial location. Patients with left hippocampal sclerosis were consistently impaired in the allocentric conditions of all 3 tasks but not in the egocentric conditions. Patients with right hippocampal sclerosis were impaired to a lesser extent and in only 2 of the 3 tasks. It was concluded that hippocampal structures are crucial for allocentric, but not egocentric, spatial memory. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献