全文获取类型
收费全文 | 189篇 |
免费 | 19篇 |
国内免费 | 57篇 |
专业分类
综合类 | 4篇 |
化学工业 | 59篇 |
机械仪表 | 6篇 |
建筑科学 | 1篇 |
轻工业 | 20篇 |
石油天然气 | 2篇 |
无线电 | 78篇 |
一般工业技术 | 23篇 |
冶金工业 | 6篇 |
原子能技术 | 62篇 |
自动化技术 | 4篇 |
出版年
2024年 | 1篇 |
2023年 | 7篇 |
2022年 | 24篇 |
2021年 | 26篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 18篇 |
2015年 | 7篇 |
2014年 | 18篇 |
2013年 | 23篇 |
2012年 | 18篇 |
2011年 | 15篇 |
2010年 | 9篇 |
2009年 | 8篇 |
2008年 | 8篇 |
2007年 | 6篇 |
2006年 | 8篇 |
2005年 | 6篇 |
2004年 | 6篇 |
2003年 | 7篇 |
2002年 | 2篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 1篇 |
1997年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有265条查询结果,搜索用时 15 毫秒
1.
Ryo Hashikawa Yasuhiro Fujii Atsushi Kinomura Takeshi Saito Arifumi Okada Takashi Wakasugi Kohei Kadono 《Journal of the American Ceramic Society》2019,102(4):1642-1651
Radiophotoluminescence phenomena have been widely investigated on various types of materials for dosimetry applications. We report that an aluminoborosilicate glass containing 0.005 mol% copper exhibits intense photoluminescence in the visible region induced by X-ray and γ-ray irradiation. The luminescence is assigned to the 3d94s1 → 3d10 transition of Cu+. The proportionality of the intensity of the induced photoluminescence to the irradiation dose was confirmed up to 0.5 kGy using 60Co γ-ray irradiation. Based on the spectroscopic results, a potential mechanism was proposed for the enhancement of the photoluminescence. The exposure to the ionizing radiation generates electron-hole pairs in the glass, and the electrons are subsequently captured by the Cu2+ ions, which are converted to Cu+ and emit the luminescence. For the glass containing 0.01 mol% copper, the pronounced enhancement of the photoluminescence was not observed because the reverse reaction, ie, the capture of the holes by the Cu+ ions, becomes prominent. The photoluminescence induced by the irradiation was stably observed for the glasses kept at room temperature and even for the glasses heat-treated at 150°C. However, the induced photoluminescence could be eliminated by the heat treatment at a temperature at 500°C, and the glass returned to the initial pre-irradiation state. The Cu-doped aluminoborosilicate glass is a potential candidate for use in dosimetry applications. 相似文献
2.
3.
Albul V. I. Bychkov V. B. Gusev K. E. Demidov V. S. Demidova E. V. Kurchanov A. F. Luk'yashin V. E. Sokolov A. Yu. 《Measurement Techniques》2003,46(8):810-814
A monitor is proposed based on ultrasonic production when ionizing radiation passes through a medium. The recording element is a 0.2 mm aluminum plate mounted in a ceramic acoustic converter AC in the form of a wedge of thickness 2 mm. The low plate thickness minimizes the beam parameter distortion, while special technology used in the AC provides high sensitivity. The device has been calibrated in the proton beam from the ITEP accelerator at 200 MeV with 2·109–6·1010 particles in a pulse and a pulse length of 70 nsec. 相似文献
4.
报道了以茈为荧光探针,探讨小剂量~(60)Co γ射线照射后小鼠胸腺细胞膜流动性的变化。结果表明,剂量在0.25-1.00Gy范围,胸腺细胞膜流动性降低与剂量之间呈明显线性关系。从0.50Gy起,辐照组荧光强度比值I_1/I_2与I_3/I_2与对照组的比较存有显著差异(P<0.05)。提示淋巴细胞膜流动性的变化可作为小剂量辐照早期效应的敏感指标。 相似文献
5.
Michael Hausmann Martin Falk Charlotte Neitzel Andreas Hofmann Abin Biswas Theresa Gier Iva Falkova Dieter W. Heermann Georg Hildenbrand 《International journal of molecular sciences》2021,22(7)
In cancer therapy, the application of (fractionated) harsh radiation treatment is state of the art for many types of tumors. However, ionizing radiation is a “double-edged sword”—it can kill the tumor but can also promote the selection of radioresistant tumor cell clones or even initiate carcinogenesis in the normal irradiated tissue. Individualized radiotherapy would reduce these risks and boost the treatment, but its development requires a deep understanding of DNA damage and repair processes and the corresponding control mechanisms. DNA double strand breaks (DSBs) and their repair play a critical role in the cellular response to radiation. In previous years, it has become apparent that, beyond genetic and epigenetic determinants, the structural aspects of damaged chromatin (i.e., not only of DSBs themselves but also of the whole damage-surrounding chromatin domains) form another layer of complex DSB regulation. In the present article, we summarize the application of super-resolution single molecule localization microscopy (SMLM) for investigations of these structural aspects with emphasis on the relationship between the nano-architecture of radiation-induced repair foci (IRIFs), represented here by γH2AX foci, and their chromatin environment. Using irradiated HeLa cell cultures as an example, we show repair-dependent rearrangements of damaged chromatin and analyze the architecture of γH2AX repair clusters according to topological similarities. Although HeLa cells are known to have highly aberrant genomes, the topological similarity of γH2AX was high, indicating a functional, presumptively genome type-independent relevance of structural aspects in DSB repair. Remarkably, nano-scaled chromatin rearrangements during repair depended both on the chromatin domain type and the treatment. Based on these results, we demonstrate how the nano-architecture and topology of IRIFs and chromatin can be determined, point to the methodological relevance of SMLM, and discuss the consequences of the observed phenomena for the DSB repair network regulation or, for instance, radiation treatment outcomes. 相似文献
6.
Simonetta Pazzaglia Barbara Tanno Francesca Antonelli Paola Giardullo Gabriele Babini Prabal Subedi Omid Azimzadeh Zohaib N. Khan Kateryna Oleksenko Fabian Metzger Christine von Toerne Damien Traynor Dinesh Medipally Aidan D. Meade Munira Kadhim Fiona M. Lyng Soile Tapio Anna Saran Mariateresa Mancuso 《International journal of molecular sciences》2021,22(8)
The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health. 相似文献
7.
Chandrasekharam N. Nagineni Sarwat Naz Rajani Choudhuri Gadisetti V. R. Chandramouli Murali C. Krishna Jeffrey R. Brender John A. Cook James B. Mitchell 《International journal of molecular sciences》2021,22(9)
Understanding the global metabolic changes during the senescence of tumor cells can have implications for developing effective anti-cancer treatment strategies. Ionizing radiation (IR) was used to induce senescence in a human colon cancer cell line HCT-116 to examine secretome and metabolome profiles. Control proliferating and senescent cancer cells (SCC) exhibited distinct morphological differences and expression of senescent markers. Enhanced secretion of pro-inflammatory chemokines and IL-1, anti-inflammatory IL-27, and TGF-β1 was observed in SCC. Significantly reduced levels of VEGF-A indicated anti-angiogenic activities of SCC. Elevated levels of tissue inhibitors of matrix metalloproteinases from SCC support the maintenance of the extracellular matrix. Adenylate and guanylate energy charge levels and redox components NAD and NADP and glutathione were maintained at near optimal levels indicating the viability of SCC. Significant accumulation of pyruvate, lactate, and suppression of the TCA cycle in SCC indicated aerobic glycolysis as the predominant energy source for SCC. Levels of several key amino acids decreased significantly, suggesting augmented utilization for protein synthesis and for use as intermediates for energy metabolism in SCC. These observations may provide a better understanding of cellular senescence basic mechanisms in tumor tissues and provide opportunities to improve cancer treatment. 相似文献
8.
CMOS图像传感器(CIS)工作在空间辐射或核辐射环境中遭受的辐照损伤问题备受关注。对CIS辐照损伤效应进行仿真模拟研究有助于深入揭示辐照损伤机理,进而开展抗辐射加固设计,有效提升CIS抗辐照能力。文章通过梳理国内外开展CIS辐照损伤效应仿真模拟研究方面的进展情况,结合课题组已开展的电子元器件辐照效应仿真模拟和实验研究基础,从CIS器件建模、时序驱动电路建模、辐照损伤效应建模、仿真模拟结果校验等方面探讨了CIS辐照损伤效应的仿真模拟方法,分析总结了当前CIS辐照效应仿真模拟研究中亟待解决的关键技术问题。 相似文献
9.
10.
介绍了UV、臭氧和电离辐射消毒技术的原理以及主要优、缺点,比较了3种消毒方式的消毒效果、消毒副产物以及影响因素,并对各种工艺在1×104 m3/d、5×104 m3/d、1×105 m3/d处理规模下的工程投资总额、总运行成本和单位运行成本进行了经济分析。结果表明:当污水厂处理规模为1×104 m3/d时,UV、臭氧和电离辐射消毒工艺的单位运行成本分别为:0.075元/m3,0.21元/m3,0.25元/m3;当污水厂处理规模为5×104 m3/d时,UV、臭氧和电离辐射消毒工艺的单位运行成本分别为:0.049元/m3,0.19元/m3,0.17元/m3;当污水厂处理规模为1×105 m3/d时,UV、臭氧和电离辐射消毒工艺的单位运行成本分别为:0.041元/m3,0.17元/m3,0.16元/m3。 相似文献