TiO2/MXene-Assisted LDI-MS for Urine Metabolic Profiling in Urinary Disease

Cancer remains an intractable medical problem. Rapid diagnosis and identification of cancer are critical to differentiate it from nonmalignant diseases. High-throughput biofluid metabolic analysis has potential for cancer diagnosis. Nevertheless, the present metabolite analysis method does not meet the demand for high-throughput screening of diseases. Herein, a high-throughput, cost-effective, and noninvasive urine metabolic profiling method based on TiO₂/MXene-assisted laser desorption/ionization mass spectrometry (LDI-MS) is presented for the efficient screening of bladder cancer (BC) and nonmalignant urinary disease. Combined with machine learning, TiO₂/MXene-assisted LDI-MS enables high diagnostic accuracy (96.8%) for the classification of patient groups (including 47 BC and 46 ureteral calculus (UC) patients) from healthy controls (113 cases). In addition, BC patients can also be identified from noncancerous UC individuals with an accuracy of 88.3% in the independent test cohort. Furthermore, metabolite variations between BC and UC individuals are investigated based on relative quantification, and related pathways are also discussed. These results suggest that this method, based on urine metabolic patterns, provides a potential tool for rapidly distinguishing urinary diseases and it may pave the way for precision medicine.     

中扬子及邻区层序地层与原型盆地演化

中扬子及邻区原型盆地可划分为 9个大层序,其中,1～6大层序由中、古生代海相地层组成;第 7大层序为早、中侏罗纪的陆相沉积;第 8大层序为晚侏罗世的前渊沉积;第 9层序为晚白垩世至第三纪的伸展盆地。震旦纪,中部地区为台地相环境,向南为浅海陆棚环境,向北以陆表海为主;寒武纪至早奥陶世为典型的大陆边缘盆地;中、晚奥陶世至志留纪为裂谷盆地发展阶段;泥盆纪至石炭纪该区发生广泛海侵,与华南海域和太平洋海域多处相连;二叠纪至早、中三叠世为原型盆地的重要转型时期,随着分隔秦岭微板块与扬子板块的勉略古洋盆向东打开,扬子北缘由前期的区域性隆起转变为向北加深的大陆边缘盆地;晚三叠世经历了两次幕式旋回,巴东组沉积时期盆地沉降缓慢,九里岗组沉积时期则较快;早、中侏罗世原型盆地早幕 (早侏罗世)沉积缓慢,晚幕 (中侏罗世)快速沉降,以水下沉积作用为主;晚侏罗世可划分为两大构造演化阶段,早期构造活动相对平静,晚期强烈;晚白垩世至老第三纪,盆地范围缩小,以湖泊、河流体系为主。由此,中扬子及邻区在地质历史时期经历了 4种不同性质的原型盆地,具有幕式充填特征。     

变长线扫描选择性激光烧结快速成型工艺的质量和效率优势分析

本文分析变长线扫描选择性激光烧结快速成型工艺对点扫描工艺的质量和效率优势.对二者光学系统结构作分析对比,对焦斑和线束上的功率密度作计算对比.变长线扫描系统采用的扫描方式和聚焦元件使线束宽度小且恒定,线束功率密度与点扫描焦斑的相当.变长线扫描选择性激光烧结快速成型工艺的质量优势是明显的,效率比点扫描工艺提高一倍左右.     

混凝土渠道糙率原型观测

糙率是渠道水力设计的关键技术参数之一，其值的准确选取决于已建工程原型观测成果的类比。选择3条不同衬砌特性的混凝土渠道进行糙率原型观测，对观测方法及步骤做了较详细描述；计算出了3条渠道的糙率，对其存在误差进行了分析探讨，可为今后进一步开展相关课题研究积累经验并供同行参考。     

小浪底水利枢纽的初期运行

总结了小浪底水利枢纽投运初期的水沙情况、孔板洞原型观测试验、调水调沙试验和枢纽的安全监测情况,介绍了大坝防渗、转轮裂纹问题的处理方案,总结了枢纽在防洪、防凌、减淤、供水和发电等方面发挥的作用。试验和对监测资料的分析表明,枢纽运行稳定,孔板洞设计合理、消能效果显著,各部位建筑物性态稳定,发挥了巨大的综合效益。     

大窝山隧道进口围岩快速掘进施工组织与管理

结合工程概况及工程特点,从机械设备配置、劳动力组织、现场管理等方面介绍了大窝山隧道进口Ⅱ级,Ⅲ级围岩段的快速掘进施工组织与管理措施,为类似隧道的快速掘进施工组织与管理提拱了相关经验.     

EFFECT OF STREAMLINE CURVATURE AND SOME OTHER CONDITIONS ON THE TURBULENT STRUCTURES IN THE OTHER REGION OF AN OBSTACLE

ＥＦＦＥＣＴＯＦＳＴＲＥＡＭＬＩＮＥＣＵＲＶＡＴＵＲＥＡＮＤＳＯＭＥＯＴＨＥＲＣＯＮＤＩＴＩＯＮＳＯＮＴＨＥＴＵＲＢＵＬＥＮＴＳＴＲＵＣＴＵＲＥＳＩＮＴＨＥＯＴＨＥＲＲＥＧＩＯＮＯＦＡＮＯＢＳＴＡＣＬＥＬｉｕＳｈｉ－ｈｅ（ＷｕｈａｎＵｎｉｖｅｒｓｉｔ...     

隧道二次衬砌混凝土快速施工技术

结合某隧道施工实例，阐述了混凝土快速施工方案，探索了采用机械化混凝土输送系统配合整体液压衬砌台车进行混凝土快速施工技术，并提出了系统的设计、选形与配套措施。     

某半导体产品的设计和快速实现研究

研究了产品开发及快速实现过程中任务获取、任务分配、进度的协调、信息传输等相关问题,并以某半导体产品为例,进行了产品的设计和快速实现,为缩短产品开发和上市周期、提高产品的市场竞争力积累经验。     

Structure of rapidly solidified aluminum alloys

This paper is a summary of an extensive research program carried out by the authors on the structure of rapidly solidified aluminum alloys; and a comparison with the work of others also involved in this field. The paper discusses the changes in the dendritic and non-dendritic structure of the matrix at cooling rates from 10^–3 to 10¹⁰ K/s and discusses the hetergeneity of the structure caused by interdendritic-segretion during solidification.