The (Poly)Pharmacology of Cannabidiol in Neurological and Neuropsychiatric Disorders: Molecular Mechanisms and Targets

Cannabidiol (CBD), the major nonpsychoactive Cannabis constituent, has been proposed for the treatment of a wide panel of neurological and neuropsychiatric disorders, including anxiety, schizophrenia, epilepsy and drug addiction due to the ability of its versatile scaffold to interact with diverse molecular targets that are not restricted to the endocannabinoid system. Albeit the molecular mechanisms responsible for the therapeutic effects of CBD have yet to be fully elucidated, many efforts have been devoted in the last decades to shed light on its complex pharmacological profile. In particular, an ever-increasing number of molecular targets linked to those disorders have been identified for this phytocannabinoid, along with the modulatory effects of CBD on their cascade signaling. In this view, here we will try to provide a comprehensive and up-to-date overview of the molecular basis underlying the therapeutic effects of CBD involved in the treatment of neurological and neuropsychiatric disorders.     

Osteosarcoma Pathogenesis Leads the Way to New Target Treatments

Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.     

Xanthohumol for Human Malignancies: Chemistry,Pharmacokinetics and Molecular Targets

Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers.     

应用膨胀算法提取目标的直接定位算法

为了解决被动雷达系统中的多发射源定位问题，提出了一种基于多重信号分类(MUSIC)算法和图像膨胀(IE)算法的直接定位方法。该方法结合了谱分析中的MUSIC思想，通过对接收量测协方差矩阵进行特征分析求解目标的位置。首先，在目标个数未知的前提下，利用Akaike信息准则(AIC)来确定模型阶数；然后，推导了基于MUSIC的定位代价函数；之后，利用图像膨胀算法处理得到的代价函数平面；最后，膨胀处理后的输出为目标个数及目标位置的估计值。提出的算法有效地解决了目标检测及提取的问题，能够确定多个目标的位置坐标，为后续的定位性能分析提供可能性，也保证了算法的完整性。进一步地分析了多个临近目标情况下影响目标提取性能的主要因素。     

线性调频的脉冲压缩雷达视频信号仿真

利用数字方法实现线性调频的脉冲压缩雷达视频目标模拟信号具有诸多优点：信号模拟的精度高，灵活性好，幅度、相位补偿方便，可以模拟复杂情况，系统结构简单，可靠性高，可扩展性强。详细介绍了基于FPGA设计线性调频的脉冲压缩雷达视频目标模拟信号的原理、结构、具体实现以及简要的性能分析。结果表明该方案性能良好，具有现实可实现性。     

Overview of ship-design expert systems

Expert systems constitute a branch of artificial intelligence, and their unique characteristics enable computer systems to perform at the level of a human expert by the use of algorithms that can capture domain-specific knowledge. Through an extensive survey of research about ship-design expert systems, we conclude that although development and implementation of expert systems for ship design offer substantial barriers, the shipbuilding industry needs them nonetheless. We examine the major reasons that use of expert systems in this industry has lagged behind. These include the problems of integration with existing computer-aided design systems, problems of knowledge representation and sizable development costs. We discuss in detail some key factors that can lead to the solution of these problems.     

Alpha induced reactions on Sn: An experimental study of excitation functions and possible production pathways

In the frame of a systematic study of light ion induced threshold reactions on natural tin (Sn) excitation functions for alpha particles induced reactions are presented in a 12–38 MeV energy domain. Using a stacked foil activation method the following radioisotopes were identified: ¹¹⁶Te, ¹¹⁷Te, ¹¹⁸Te, ¹¹⁹Te, ¹²¹Te, ¹²³Te, ¹¹⁷Sb, ¹¹⁸Sb, ¹²⁰Sb, ¹²²Sb, ¹²⁴Sb, ¹²⁶Sb, ¹¹⁷Sn, ¹¹¹In. The experimental cross sections for these isotopes are presented for the first time in this energy range and a direct comparison with values calculated with the ALICE-IPPE code is discussed. Possible use of these data for production of some isotopes relevant in nuclear medicine is suggested.     

高水头船闸输水廊道反弧门水弹性振动试验研究

本文简要介绍水弹性振动模型试验的相似准则，用近似满足水弹性相似准则的有机玻璃模型对－高水头船闸反弧形阀门进行流激振动试验研究．试验表明阀门的振动是随机振动，不仅有质量振动而且有结构振动，有若干阶模态被激发参与振动。在开门和关门过程中，阀门面板脉动压力和阀门振动是不大的，与葛洲坝船闸类似阀门间歇开启的振动水平相当。由于常压模型不能正确模拟空化现象，对于廊道内可能产生的空泡溃灭所引起的阀门振动尚需通过减压模型进行研究。     

一种多传感器信息融合点目标识别方法（二）

提出了一种多传感器信息融合识别空间复杂弹道式目标及其伴随诱饵的识别模型。将人工神经网络和确定性理论结合起来，以神经网络的输出代替应用确定性理论所需的有关领域专家的知识和经验，并用确定性理论进行不同空域和时域的信息融合。仿真结果表明，经过融合后，大大改善了识别效果。     

铝合金高速船船体建造工艺

简述了ＬＦ１５和ＬＦ１６两种新型船用耐蚀可焊铝合金及其配套焊接材料在实船建造中的应用情况。阐述了铝合金全焊结构船体建造的关键技术及我国铝船体建造的３种方法