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排序方式: 共有274条查询结果,搜索用时 15 毫秒
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YOSHIHARU KARIYA TADATOMO SUGA 《Fatigue & Fracture of Engineering Materials & Structures》2007,30(5):413-419
This paper details the deformation mechanism and low‐cycle fatigue life of eutectic solder alloys at high temperature (around 0.8Tm). Grain boundary sliding generally nucleates a wedge‐type cavity that reduces the low‐cycle fatigue life of metals. In this study, grain boundary sliding has promoted intergranular failure contributing to the reduction in fatigue life of Sn–Ag–Cu alloy. However, grain boundary sliding has exerted no deleterious effects on fatigue resistance of eutectic Pb–Sn and Bi–Sn alloys. The phase boundary sliding with very fine microstructure induces exceptional ductility in these alloys leading to superior low‐cycle fatigue endurance for theses eutectic Pb–Sn and Bi–Sn alloys. 相似文献
3.
Roberto Lande Immacolata Pietraforte Anna Mennella Raffaella Palazzo Francesca Romana Spinelli Konstantinos Giannakakis Francesca Spadaro Mario Falchi Valeria Riccieri Katia Stefanantoni Curdin Conrad Cristiano Alessandri Fabrizio Conti Loredana Frasca 《International journal of molecular sciences》2021,22(4)
LL37 acts as T-cell/B-cell autoantigen in Systemic lupus erythematosus (SLE) and psoriatic disease. Moreover, when bound to “self” nucleic acids, LL37 acts as “danger signal,” leading to type I interferon (IFN-I)/pro-inflammatory factors production. T-cell epitopes derived from citrullinated-LL37 act as better antigens than unmodified LL37 epitopes in SLE, at least in selected HLA-backgrounds, included the SLE-associated HLA-DRB1*1501/HLA-DRB5*0101 backgrounds. Remarkably, while “fully-citrullinated” LL37 acts as better T-cell-stimulator, it loses DNA-binding ability and the associated “adjuvant-like” properties. Since LL37 undergoes a further irreversible post-translational modification, carbamylation and antibodies to carbamylated self-proteins other than LL37 are present in SLE, here we addressed the involvement of carbamylated-LL37 in autoimmunity and inflammation in SLE. We detected carbamylated-LL37 in SLE-affected tissues. Most importantly, carbamylated-LL37-specific antibodies and CD4 T-cells circulate in SLE and both correlate with disease activity. In contrast to “fully citrullinated-LL37,” “fully carbamylated-LL37” maintains both innate and adaptive immune-cells’ stimulatory abilities: in complex with DNA, carbamylated-LL37 stimulates plasmacytoid dendritic cell IFN-α production and B-cell maturation into plasma cells. Thus, we report a further example of how different post-translational modifications of a self-antigen exert complementary effects that sustain autoimmunity and inflammation, respectively. These data also show that T/B-cell responses to carbamylated-LL37 represent novel SLE disease biomarkers. 相似文献
4.
The insecticidal nonprotein amino acid S-(37k30v880335005/xxlarge946.gif" alt="beta" align="MIDDLE" BORDER="0">-carboxyethyl)-cysteine (S-CEC) is the major free amino acid in the seeds of severalCalliandra spp. where it accounts for up to 2.9 % of dry weight. Lesser amounts of other related S-containing amino acids and an array of nonprotein imino acids derived from pipecolic acid are other constituents. High concentrations of imino acids, which also show insecticidal activity, are maintained in the mature leaves, but sulfur compounds are lacking. In this study the disappearance of S-CEC from the germinating seeds and young seedlings ofC. rubescens was monitored over time. After 10 weeks, S-CEC continues to be found in high concentrations in the stems and new leaves. As young leaves mature, sulfur compounds quickly decrease in concentration. Traces of S-CEC are found in new leaves of plants up to nine months after germination. Whether high concentration of S-CEC in young leaves is due to transportation from the seed or de novo synthesis is unclear. The ecological implications are discussed. 相似文献
5.
The experimental tests of tensile for lead-free solder Sn-3.5Ag were performed for the general work temperatures range from
11 to 90 °C and strain rate range from 5×10−5 to 2×10−2 s−1, and its stress—strain curves were compared to those of solder Sn-37Pb. The parameters in Anand model for solder Sn-3.5Ag
were fitted based on experimental data and nonlinear fitting method, and its validity was checked by means of experimental
data. Furthermore, the Anand model was used in the FEM analysis to evaluate solder joint thermal cycle reliability. The results
show that solder Sn-3.5Ag has a better creep resistance than solder Sn-37Pb. The maximum stress is located at the upper right
corner of the outmost solder joint from the symmetric center, and thermal fatigue life is predicted to be 3.796×104 cycles under the calculated conditions.
Foundation item: Project(50376076) supported by the National Natural Science Foundation of China 相似文献
6.
采用搭接面积为1mm^2的单搭接钎焊接头,研究了恒定温度下,应力对纳米颗粒增强的SnPb基复合钎料钎焊接头的蠕变寿命的影响。结果表明,纳米颗粒增强的SnPb基复合钎料的蠕变抗力优于传统SnPb钎料。同时钎焊接头的蠕变寿命随应力增加而降低,且应力对复合钎料钎焊接头蠕变寿命的影响较传统63Sn37Pb钎料明显。 相似文献
7.
Gil Francopoulo Nuria Bel Monte George Nicoletta Calzolari Monica Monachini Mandy Pet Claudia Soria 《Language Resources and Evaluation》2009,43(1):57-70
Optimizing the production, maintenance and extension of lexical resources is one the crucial aspects impacting natural language
processing (NLP). A second aspect involves optimizing the process leading to their integration in applications. With this
respect, we believe that a consensual specification on monolingual, bilingual and multilingual lexicons can be a useful aid
for the various NLP actors. Within ISO, one purpose of Lexical Markup Framework (LMF, ISO-24613) is to define a standard for
lexicons that covers multilingual lexical data.
相似文献
Claudia SoriaEmail: |
8.
Most empirical investigations of the business cycles in the United States have excluded the dimension of asymmetric conditional volatility. This paper analyses the volatility dynamics of the US business cycle by comparing the performance of various multivariate generalised autoregressive conditional heteroskedasticity (GARCH) models. In particular, we propose two bivariate GARCH models to examine the evidence of volatility asymmetry and time-varying correlations concurrently, and then apply the proposed models to five sectors of Industrial Production of the United States. Our findings provide strong evidence of asymmetric conditional volatility in all sectors, and some support of time-varying correlations in various sectoral pairs. This has important policy implications for government to consider the effective countercyclical measures during recessions. 相似文献
9.
In this paper, two delayed SEIR epidemic models with continuous and impulsive vaccination and saturating incidence are investigated. The dynamical behaviors of the disease are analyzed. For continuous vaccination, we obtain a basic reproductive number R1 and prove that if R1≤1 then the disease-free equilibrium is globally attractive and if R1>1 then the disease is permanent by using the Lyapunov functional method. For impulsive vaccination, we obtain two thresholds R∗ and R∗ and prove that if R∗<1 then the disease-free periodic solution is globally attractive and if R∗>1 then the disease is permanent by using the comparison theorem of impulsive differential equation and the Lyapunov functional method. Lastly, we compared the effects of two vaccination strategies. 相似文献
10.
On the convective nature of the instability of a front undergoing a supercritical Turing bifurcation
Fronts are traveling waves in spatially extended systems that connect two different spatially homogeneous rest states. If the rest state behind the front undergoes a supercritical Turing instability, then the front will also destabilize. On the linear level, however, the front will be only convectively unstable since perturbations will be pushed away from the front as it propagates. In other words, perturbations may grow but they can do so only behind the front. It is of interest to show that this behavior carries over to the full nonlinear system. It has been successfully done in a case study by Ghazaryan and Sandstede [A. Ghazaryan, B. Sandstede, Nonlinear convective instability of Turing-unstable fronts near onset: a case study, SIAM J. Appl. Dyn. Syst. 6 (2007) 319–347]. In the present paper, analogous results are obtained for the same system as in Ghazaryan and Sandstede (2007), but for a different parameter regime. 相似文献