药物相互作用研究在新药研发和审评决策中的应用

药物相互作用改变了剂量效应关系，可能会降低疗效或增加毒性，是临床应用中合并用药治疗时重要的考虑因素。预测具有临床意义的药物相互作用是药物研发过程中获益风险评估的重要环节。本文概述了药物研发过程中药物相互作用研究的目的和意义，体内和体外研究的主要内容；梳理分析了2020年国家药品监督管理局（National Medical Products Administration, NMPA）和美国食品药品监督管理局（Food and Drug Administration, FDA）批准上市的新药药物相互作用研究情况，旨在为我国药物研发过程中药物相互作用研究及其监管审评提供参考。     

Precipitating spinel into precursor glass and its assistance in crystallization

The crystallization phenomena of spinel in CaO-MgO-Al₂O₃-SiO₂-Fe₂O₃ glass have received much attention due to the particular role in preparation of glass-ceramic materials, which represent an effective option to manage hazardous waste. In this study, both preliminary spinel and secondary spinel were precipitated in the precursor glass. The formation of these spinel was meticulously assessed by a combination of X-ray diffractometry and scanning electron microscopy. The structure of the microenvironment in the precursor glass was characterized by Raman spectrums. These advanced techniques highlight the potential for one-step crystallization of the glass. The investigation, which focused on one-step crystallization, demonstrated the growth of pyroxene on spinel accompanying a migration of chromium. The results also show the microstructure of the obtained glass-ceramic was very dependent on the heat-treat temperature. This study not only unambiguously reveals the precipitation mechanisms of spinel but also provides more documentation for one-step crystallization in the glass-ceramics field.     

Occupational Factors and 5-Year Weight Change Among Men in a Danish National Cohort.

This study explored whether factors related to the work environment could predict changes in body mass index (BMI) and whether the effect of psychosocial factors was dependent on baseline BMI. The sample consisted of 1,980 male employees from the Danish National Work Environment Cohort Study. Changes in BMI between 1995 and 2000 were analyzed, by multiple regression, as a function of background variables and a series of occupational variables obtained in 1995. Age, baseline BMI, job insecurity, and psychological demands predicted changes in BMI. Job insecurity and high or low psychological demands increased the likelihood of weight gain among obese employees, whereas they increased the likelihood of weight loss among employees with a low BMI. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

国防计量工作改革的探讨

阐述了国防计量与民用计量的差别，计量工作的原动力以及对国防计量工作改革的探讨。     

《宏观经济学》课程教学体系梳理

宏观经济学从资源如何充分利用这一独特的研究视角出发，以国民收入的决定为核心，以从二部门到部门到四部门为横线，从简单模型到扩展模型到总供求模型为纵线，从理论到政策为立线，构造了一个立体的理论框架体系。对宏观经济学的理论脉络进行梳理，能帮助学生提纲挈领地把握宏观经济学的理论体系。     

Two interviews with Reik.

This article describes two interviews with Theodor Reik. Explored topics include Reik's relationship with Sigmund Freud, psychoanalytic literature, and the history of the psychoanalytic movement. The author concludes with an analysis of his impressions of Reik. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

AssetCollector: a system for managing collections of cultural assets

In this paper, AssetCollector is presented, which is a system for managing collections of cultural assets. AssetCollector covers the needs of collection curators towards defining, populating and searching a collection in a flexible way, while supporting them in generating reports based on the collection’s assets and reusing them in order to build web sites and CD-ROMs. In order to support the above functionality, the system provides the content structuring subsystem, the content input subsystem, the search subsystem and the report subsystem. The use of the subsystems is straightforward and requires no technical skills from the curators. AssetCollector has been successfully applied for organizing various collections of cultural assets in Greece, such as archaeological sites, museums and published books. In the future, an evaluation procedure is planned in order to further refine the use of the system according to the targeted users’ needs. Furthermore, more import and export facilities will be provided, which will make the system compliant with widely accepted standards.     

发展创新民族风格的包装设计

首先揭示出民族风格是与时代风格对立统一、相互依存的一个概念。因而特定的时代需要具有时代精神的民族风格──创新民族风格。在探索此风格的过程中．我们首先要学习日本的战略，然后在学习的基础上实现超越。     

浅析当前环境下国有资产的现状和管理对策

改革开放使中国经济实现了持续高速的发展。然而,随着改革的不断深入,国有资产面临着在新经济环境下的角色转换,在此过程中由于各种原因每年有数百亿元的国有资产流失,所以,国有资产的保值增值成为现阶段乃至将来一段时间我国政府的重大经济课题。本文对国有资产的历史和现状进行了分析并从多角度提出了一些管理方面的看法。