Twin screw granulation – review of current progress

Twin screw granulation (TSG) is a new process of interest to the pharmaceutical community that can continuously wet granulate powders, doing so at lower liquid concentrations and with better product consistency than found by a high shear batch mixer. A considerable body of research has evolved over the short time since this process was introduced but generally with little comparison of results. A certain degree of confidence has been developed through these studies related to how process variables and many attributes of machinery configuration will affect granulation but some major challenges still lay ahead related to scalability, variations in the processing regimes related to degree of channel fill and the impact of wetting and granulation of complex powder formulations. This review examines the current literature for wet granulation processes studied in twin screw extrusion machinery, summarizing the influences of operational and system parameters affecting granule properties as well as strives to provide some practical observations to newly interested users of the technique.     

Inverted pendulum stabilization: Characterization of codimension-three triple zero bifurcation via multiple delayed proportional gains

The paper considers the problem of stabilization of systems possessing a multiple zero eigenvalue at the origin. The controller that we propose, uses multiple delayed measurements instead of derivative terms. Doing so, we increase the performances of the closed loop in presence of system uncertainties and/or noisy measurements. The problem formulation and the analysis is presented through a classical engineering problem which is the stabilization of an inverted pendulum on a cart moving horizontally. On one hand, we perform a nonlinear analysis of the center dynamics described by a three dimensional system of ordinary differential equations with a codimension-three triple zero bifurcation. On the other hand, we present the complementary stability analysis of the corresponding linear time invariant system with two delays describing the behavior around the equilibrium. The aim of this analysis is to characterize the possible local bifurcations. Finally, the proposed control scheme is numerically illustrated and discussed.     

低剂量抑制剂Inhibex501存在下的甲烷水合物相平衡研究

含动力学抑制剂的天然气水合物相平衡研究对新型低剂量抑制剂的开发具有指导作用。在283.6 ~ 290.9 K和7.51 MPa ~ 15.97 MPa的温压范围内研究了抑制剂Inhibex501及其溶剂2-乙二醇单丁醚对甲烷水合物相平衡条件的影响。实验结果显示，0.5wt%和2.0wt%浓度的Inhibex501对甲烷水合物形成的热力学条件具有促进作用，能使甲烷水合物形成移向更高的温度或者更低的压力，而2-乙二醇单丁醚在浓度0.2wt% ~ 1.0wt%范围几乎不改变甲烷水合物形成的热力学条件，N-乙烯基己内酰胺与N-乙烯基吡咯烷酮的共聚物对水合物形成热力学条件的改变起主要作用。     

The factorial structure of the Dutch translation of the Inventory of Interpersonal Problems: A test of the long and short versions.

In this article, the authors study the factorial structure of 2 versions (64 items and 32 items) of the Dutch translation of the Inventory of Interpersonal Problems (IIP; L. M. Horowitz, L. E. Alden, J. S. Wiggins, & A. L. Pincus, 2000) in both a clinical sample (n = 382) and a student sample (n = 287). First, the authors test whether both inventories are constituted by correlated uni-dimensional subscales, and they conclude that this is true only for the short version. Second, the authors study whether the correlations between the subscales follow a circumplex pattern. This proves to be true for both versions. Coefficients alpha and correlations between the IIP-64 and IIP-32 subscales are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

铁路电力试验车软件的设计与实现

介绍了铁路电力试验车软件的设计思想、框架结构及其总体控制策略 ,并就其中的测试程序、数据库管理系统、串口通讯程序、复杂式样报表生成和系统安装程序的设计策略作了叙述。     

Least-squares integration of one-dimensional codistributions with application to approximate feedback linearization

We study the problem of approximating one-dimensional nonintegrable codistributions by integrable ones and apply the resulting approximations to approximate feedback linearization of single-input systems. The approach derived in this paper allows a linearizable nonlinear system to be found that is close to the given system in a least-squares (L ₂) sense. A linearly controllable single-input affine nonlinear system is feedback linearizable if and only if its characteristic distribution is involutive (hence integrable) or, equivalently, any characteristic one-form (a one-form that annihilates the characteristic distribution) is integrable. We study the problem of finding (least-squares approximate) integrating factors that make a fixed characteristic one-form close to being exact in anL ₂ sense. A given one-form can be decomposed into exact and inexact parts using the Hodge decomposition. We derive an upper bound on the size of the inexact part of a scaled characteristic one-form and show that a least-squares integrating factor provides the minimum value for this upper bound. We also consider higher-order approximate integrating factors that scale a nonintegrable one-form in a way that the scaled form is closer to being integrable inL ₂ together with some derivatives and derive similar bounds for the inexact part. This allows a linearizable nonlinear system that is close to the given system in a least-squares (L ₂) sense together with some derivatives to be found. The Sobolev embedding techniques allow us to obtain an upper bound on the uniform (L _∞) distance between the nonlinear system and its linearizable approximation. This research was supported in part by NSF under Grant PYI ECS-9396296, by AFOSR under Grant AFOSR F49620-94-1-0183, and by a grant from the Hughes Aircraft Company.     

Electronic data acquisition forms in construction management

Effective management of construction projects depends on good access to and control of data, especially data pertaining to cost and schedule control functions. However, the proper design and development of automated mechanisms have not had the facility to acquire and store quality data in a timely manner. The purpose of this paper, then, is to discuss a prototype, automated data acquisition system that was developed to support an integrated project management system. The data acquisition system is composed of an integrated set of electronic forms used in conjunction with a bar coding data-entry tool.     

Behavioral Phenotype of the Reeler Mutant Mouse: Effects of Reln Gene Dosage and Social Isolation.

Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

SBR工艺污泥膨胀的纠正方法

在对国内外有关资料的研究基础上，介绍了几种应对SBR反应池内污泥膨胀的措施。着重叙述了氯化法和无机合成絮凝剂法的应用注意点及如何定量运用这两种方法，同时给出了相应的工程实例。     

QUANTITATIVE ANALYSIS OF FLAVANOIDS IN BARLEY,HOPS AND BEER BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC)

This work describes a method for the quantitative analysis of flavanoids of barley, hops and beer by HPLC. This method requires only about 4 h and it gives representative and reproducible results. A few results obtained by this method are given for barley and hops.