全文获取类型
收费全文 | 425篇 |
免费 | 79篇 |
国内免费 | 3篇 |
专业分类
综合类 | 1篇 |
化学工业 | 293篇 |
金属工艺 | 2篇 |
机械仪表 | 12篇 |
建筑科学 | 1篇 |
能源动力 | 7篇 |
轻工业 | 176篇 |
水利工程 | 1篇 |
无线电 | 3篇 |
一般工业技术 | 10篇 |
自动化技术 | 1篇 |
出版年
2024年 | 1篇 |
2023年 | 11篇 |
2022年 | 14篇 |
2021年 | 15篇 |
2020年 | 10篇 |
2019年 | 23篇 |
2018年 | 27篇 |
2017年 | 26篇 |
2016年 | 25篇 |
2015年 | 25篇 |
2014年 | 31篇 |
2013年 | 23篇 |
2012年 | 23篇 |
2011年 | 21篇 |
2010年 | 22篇 |
2009年 | 14篇 |
2008年 | 27篇 |
2007年 | 24篇 |
2006年 | 24篇 |
2005年 | 23篇 |
2004年 | 14篇 |
2003年 | 15篇 |
2002年 | 8篇 |
2000年 | 9篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1995年 | 4篇 |
1994年 | 8篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 6篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
排序方式: 共有507条查询结果,搜索用时 15 毫秒
1.
Charles A. White John F. Kennedy Anna Lombard Valeria Rossetti 《Polymer International》1985,17(4):327-329
The oligosaccharide component compositions of a series of non-reducing oligosaccharides extracted from the roots of Arnica montana L. has been determined by gel permeation chromatography (g.p.c.). The range of oligosaccharides present was found to extend beyond the octasaccharide previously reported. with 16% to 19% of the oligosaccharides having a degree of polymerisation of between 11 and 19 and almost 3% having a degree of polymerisation greater than 20. The chromatographic behaviour of this series of oligosaccharides is compared with that observed for series of D-gluco-oligosaccharides. 相似文献
2.
Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2009–2010
下载免费PDF全文
![点击此处可从《Mass spectrometry reviews》网站下载免费的PDF全文](/ch/ext_images/free.gif)
David J. Harvey 《Mass spectrometry reviews》2015,34(3):268-422
3.
4.
5.
Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody–Drug Conjugation Chemistry
下载免费PDF全文
![点击此处可从《ChemMedChem》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Filip S. Ekholm Henna Pynnönen Anja Vilkman Virve Pitkänen Dr. Jari Helin Juhani Saarinen Tero Satomaa 《ChemMedChem》2016,11(22):2501-2505
Antibody–drug conjugates (ADCs) are promising alternatives to naked antibodies for selective drug‐delivery applications and treatment of diseases such as cancer. Construction of ADCs relies upon site‐selective, efficient and mild conjugation technologies. The choice of a chemical linker is especially important, as it affects the overall properties of the ADC. We envisioned that hydrophilic bifunctional chemical linkers based on carbohydrates would be a useful class of derivatization agents for the construction of linker–drug conjugates and ADCs. Herein we describe the synthesis of carbohydrate‐based derivatization agents, glycolinker–drug conjugates featuring the tubulin inhibitor monomethyl auristatin E and an ADC based on an anti‐EGFR antibody. In addition, an initial in vitro cytotoxicity evaluation of the individual components and the ADC is provided against EGFR‐positive cancer cells. 相似文献
6.
Synthesis and Evaluation of Glycoconjugates Comprising N‐Acyl‐Modified Thomsen–Friedenreich Antigens as Anticancer Vaccines
下载免费PDF全文
![点击此处可从《ChemMedChem》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shuang Sun Xiu‐Jing Zheng Chang‐Xin Huo Chengcheng Song Prof. Qin Li Prof. Xin‐Shan Ye 《ChemMedChem》2016,11(10):1090-1096
Thomsen–Friedenreich (TF) antigen is an important tumor‐associated carbohydrate antigen. Its low immunogenicity, however, limits its application in the development of anticancer vaccines. To solve this problem, several N‐acyl‐modified TF derivatives were synthesized and conjugated with carrier protein CRM197 (a mutated diphtheria toxoid cross‐reactive material). The immunological results in BALB/c mice demonstrated that these modified TF antigen conjugates could stimulate the production of higher titers of IgG antibodies that cross‐reacted with native TF antigen. These glycoconjugates showed strong lymphocyte proliferative response, suggesting that they can induce cellular immunity. Furthermore, the elicited antisera reacted strongly with TF‐positive tumor cells (4T1). In particular, the N‐monofluoroacetyl‐modified TF conjugate 4 ‐CRM197 showed the strongest complement‐dependent cytotoxicity effect against 4T1 cells, implying the potential of this glycoconjugate as an anticancer vaccine. 相似文献
7.
8.
9.
10.
Gwénaëlle Hourdin Alain Germain Claude Moreau François Fajula 《Catalysis Letters》2000,69(3-4):241-244
Ti‐BEA and Ti‐FAU, obtained by post‐synthesis treatment, and TS‐1, obtained by direct hydrothermal synthesis, have been tested
as catalysts for the Ruff oxidative degradation of calcium d‐gluconate to d‐arabinose using diluted hydrogen peroxide as oxidant.
Only large‐pore zeolites Ti‐BEA and Ti‐FAU were found to be active. It was shown, in particular, that a very rapid leaching
of titanium occurred and that the titanium species present in the solution were responsible for the catalytic activity observed.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献