Some Molecular and Cellular Stress Mechanisms Associated with Neurodegenerative Diseases and Atherosclerosis

Chronic stress is a combination of nonspecific adaptive reactions of the body to the influence of various adverse stress factors which disrupt its homeostasis, and it is also a corresponding state of the organism’s nervous system (or the body in general). We hypothesized that chronic stress may be one of the causes occurence of several molecular and cellular types of stress. We analyzed literary sources and considered most of these types of stress in our review article. We examined genes and mutations of nuclear and mitochondrial genomes and also molecular variants which lead to various types of stress. The end result of chronic stress can be metabolic disturbance in humans and animals, leading to accumulation of reactive oxygen species (ROS), oxidative stress, energy deficiency in cells (due to a decrease in ATP synthesis) and mitochondrial dysfunction. These changes can last for the lifetime and lead to severe pathologies, including neurodegenerative diseases and atherosclerosis. The analysis of literature allowed us to conclude that under the influence of chronic stress, metabolism in the human body can be disrupted, mutations of the mitochondrial and nuclear genome and dysfunction of cells and their compartments can occur. As a result of these processes, oxidative, genotoxic, and cellular stress can occur. Therefore, chronic stress can be one of the causes forthe occurrence and development of neurodegenerative diseases and atherosclerosis. In particular, chronic stress can play a large role in the occurrence and development of oxidative, genotoxic, and cellular types of stress.     

步进式加热炉钢坯跑偏测试

钢坯在炉内的横向跑偏和纵向跑偏位移量,是步进式加热炉设备的重要性能之一.重点介绍了鞍钢1780热连轧生产线步进式加热炉钢坯跑偏测试的应用技术.     

步进式加热炉炉温优化设定模型及软件开发

针对线材厂步进式加热炉实际工况，提出了基于经验规则的炉温优化设定模型和在线自学习获取知识的思想，并以炉温优化设定模型为核心，开发出加热炉计算机控制系统的优化运行软件。     

Variability in stepping direction explains the veering behavior of blind walkers.

Walking without vision results in veering, an inability to maintain a straight path that has important consequences for blind pedestrians. In this study, the authors addressed whether the source of veering in the absence of visual and auditory feedback is better attributed to errors in perceptual encoding or undetected motor error. Three experiments had the following results: No significant differences in the shapes of veering trajectories were found between blind and blindfolded participants; accuracy in detecting curved walking paths was not correlated with simple measures of veering behavior; and explicit perceptual cues to initial walking direction did not reduce veering. The authors present a model that accounts for the major characteristics of participants' veering behavior by postulating 3 independent sources of undetected motor error: initial orientation, consistent biases in step direction, and, most important, variable error in individual steps. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

步行机攀登横杆的受力模型及分析

针对４足步行机器人的横杆攀登过程，在考虑弹性变形的基础上利用刚度矩阵建立其受力模型，并通过计算机仿真对攀登过程的不同情况进行了分析，其结果为具有攀登功能的步行机构结构设计及控制算法确定提供了理论依据。     

步进梁式炉的运动研究

对国内引进的、用于粉末冶金的步进梁式炉的运动,以图解法和解析法进行了分析,并对运动参数进行了理论推导和计算。本研究结果,对解决步进粱式炉的运动故障以及进行新型设计提供了有效的理论分析和计算依据。     

钻削中产生迷切现象的机理研究

随着科学技术的发展．对孔加工精度的要求越来越高．钻削过程中的速切现象对孔加工的形状精度、位置精度有很大的影响．本文用试验、观察、解析的方法分析了钻头迷切现象与各种因素的关系，对提高孔加工精度有了新的揭示．     

CRISPR/Cas9-Mediated Generation of Pathogen-Resistant Tomato against Tomato Yellow Leaf Curl Virus and Powdery Mildew

Tomato is one of the major vegetable crops consumed worldwide. Tomato yellow leaf curl virus (TYLCV) and fungal Oidium sp. are devastating pathogens causing yellow leaf curl disease and powdery mildew. Such viral and fungal pathogens reduce tomato crop yields and cause substantial economic losses every year. Several commercial tomato varieties include Ty-5 (SlPelo) and Mildew resistance locus o 1 (SlMlo1) locus that carries the susceptibility (S-gene) factors for TYLCV and powdery mildew, respectively. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) is a valuable genome editing tool to develop disease-resistant crop varieties. In this regard, targeting susceptibility factors encoded by the host plant genome instead of the viral genome is a promising approach to achieve pathogen resistance without the need for stable inheritance of CRISPR components. In this study, the CRISPR/Cas9 system was employed to target the SlPelo and SlMlo1 for trait introgression in elite tomato cultivar BN-86 to confer host-mediated immunity against pathogens. SlPelo-knockout lines were successfully generated, carrying the biallelic indel mutations. The pathogen resistance assays in SlPelo mutant lines confirmed the suppressed accumulation of TYLCV and restricted the spread to non-inoculated plant parts. Generated knockout lines for the SlMlo1 showed complete resistance to powdery mildew fungus. Overall, our results demonstrate the efficiency of the CRISPR/Cas9 system to introduce targeted mutagenesis for the rapid development of pathogen-resistant varieties in tomato.     

一种基于VINS/FINS组合导航方法

针对视觉惯性组合导航系统中微惯性器件精度偏低,以及足部惯性导航系统航向角误差可观测性差的问题,研究了一种基于上述两种系统的信息双向融合的导航定位方案. 该方法的系统结构由安装于双足步行机器人躯干部分的惯性导航系统和安装于其足部惯性导航系统两部分组成. 惯性导航系统通过视觉同时定位与地图构建数据融合方法可以获得相对准确的航向角,足部惯性导航系统利用零速修正后的位置信息实时修正惯性导航系统中的低精度惯性器件误差,从而构建视觉与惯性信息双向融合的组合导航系统结构. 实验结果表明,该组合导航方案可以有效提高双足步行机器人的航向精度和定位精度.     

巨魾(Bagarius yarrelli)全基因组微卫星分布特征分析

对已公布在NCBI数据库中的巨魾(Bagarius yarrelli)全基因组测序结果,使用MISA软件对巨魾全基因组中的微卫星进行筛选并分析其数量与分布特征. 在巨魾基因组570 806 968 bp序列中,共筛选出360 235个完整型微卫星,其长度为6 998 449 bp,占基因序列总长度的1.23%. 在6种完整型微卫星中,微卫星数量最多的是单碱基类型,约占总数的44.65%,其余碱基类型数量排序为二碱基(43.29%)、三碱基(6.12%)、四碱基(4.80%)、五碱基(1.02%)和六碱基(0.11%). 基因组中数量最多的前10种微卫星类别分别为:A、AC、AG、AT、AAT、C、ATAG、AAAT、ACT和ATC.