反相高效液相色谱法测定赖诺普利

用反相液相色谱测定赖诺谱利含量 ,紫外检测波长为 2 1 5nm ,色谱柱为RP - 1 8(2 50× 4.6mm ,5μm) ,流动相为 68%蒸馏水 (0 .0 0 2M磷酸二氢钾 ) 2 5%甲醇 7%乙腈。在此条件下 ,能得到较好的实验结果 ,此方法简单 ,有实用价值。     

复方赖诺普利片治疗中国人群原发性高血压的临床试验设计

复方赖诺普利片限定在单药使用不满意时方可使用,对设计要求较高。本文介绍复方赖诺普利片治疗中国人群原发性高血压的临床试验设计,包括病例选择、试验设计、例数估算等。     

PLA-PEG-PLA copolymer-based polymersomes as nanocarriers for delivery of hydrophilic and hydrophobic drugs: preparation and evaluation with atorvastatin and lisinopril

Tri-block poly(lactide)–poly(ethylene glycol)–poly(lactide) (PLA–PEG–PLA) copolymers were synthesized and used to prepare polymersomes loaded separately by the hydrophobic and hydrophilic model drugs, atorvastatin and lisinopril, respectively. The resulting nanostructures were characterized by various techniques such as FTIR, DSC, PCS and AFM. The polymersomes exhibited high encapsulation efficiencies of almost 78% and 70.8% for atorvastatin and lisinopril, respectively. Investigation on FTIR and DSC results revealed that such a high encapsulation efficiency is due to strong interaction between atorvastatin and the copolymer. The impact of drug/copolymer ratio and copolymer composition on drug-loading efficiency and drug release behavior were also studied. The results showed that in case of lisinopril, polymersomes exhibited a triphasic drug release, while for atorvastatin a biphasic release profile was obtained. Overall, the results indicated that PLA–PEG–PLA polymersomes can be considered as a promising carrier for both hydrophilic and hydrophobic drugs.