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排序方式: 共有5059条查询结果,搜索用时 11 毫秒
1.
Do T. Hue Rebel Skirving Tong Chen John L. Williams Cynthia D.K. Bottema Kiro Petrovski 《Journal of dairy science》2021,104(7):8164-8176
Colostrum is essential for good neonate health; however, it is not known whether different calves absorb the nutrients from colostrum equally well. In this study, the absorption of protein, IgG, and γ-glutamyl transferase was compared in newborn dairy bull calves for 1 wk after feeding colostrum from different sources. Thirty-five Holstein-Friesian bull calves were randomly allocated into 3 groups and fed colostrum within 4 h after birth. Group A calves (n = 12) were bottle fed colostrum from their own dam for 3 d. Colostrum from these group A cows was also used as foster cow colostrum for the group B calves (n = 12), such that each group A and B calf pair received identical colostrum from each milking of the respective group A dam (10% of birth weight per day). The group C calves (n = 11) were fed 1 bottle (2 L) of pooled colostrum and transition milk (referred to as pooled colostrum), as was the standard practice on the dairy farm. The pooled colostrum was collected from the other dairy cows on the farm 0 to 4 d postpartum and stored at 4°C for less than 12 h. Blood was sampled from calves before the first feeding and at 1, 2, 3, and 7 d after birth. Levels of total solids, total protein, and IgG were higher in the dam colostrum than in the pooled colostrum. At birth, there were no differences between the calf groups for any measurements, and all calves had very low IgG levels. After receiving colostrum, the glucose, plasma γ-glutamyl transferase, serum total protein, and IgG concentrations increased significantly in all calves. There were no differences in any blood measurements at any time point between the pairs of group A and group B calves that received colostrum from the same cow except for the IgG concentration 2 d after birth. However, the group A calves had a higher total serum protein level and IgG concentration than the group C calves for all the time points after the first feeding. The group B calves had a higher IgG concentration than the group C calves on d 1, 2, and 7 after birth. Compared with groups A and B, there was no difference in the proportion of calves in group C that failed to have passive immunity transferred adequately based on the IgG threshold (<10 g/L). Thus, the calves receiving identical colostrum from the same cow had the same levels of IgG, and even the pooled colostrum provided sufficient transfer of IgG as the calves were fed within 4 h after birth. 相似文献
2.
Dr. Li Di Prof. Per Artursson Dr. Alex Avdeef Prof. Leslie Z. Benet Prof. J. Brian Houston Dr. Manfred Kansy Edward H. Kerns Prof. Hans Lennernäs Dr. Dennis A. Smith Prof. Kiyohiko Sugano 《ChemMedChem》2020,15(20):1862-1874
Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate is translatable across tissues and animal species, while the extent of absorption is dependent on drug properties, as well as in vivo physiology/pathophysiology. Design principles have been developed to guide medicinal chemistry to enhance absorption, which combine the balance of aqueous solubility, permeability and the sometimes unfavorable compound characteristic demanded by the target. Permeability assays have been implemented that enable rapid development of structure-permeability relationships for absorption improvement. Future advances in assay development to reduce nonspecific binding and improve mass balance will enable more accurately measurement of passive permeability. Design principles that integrate potency, selectivity, passive permeability and other ADMET properties facilitate rapid advancement of successful drug candidates to patients. 相似文献
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4.
A. F. Kurbatskii 《High Temperature》2004,42(1):79-87
The difference in the turbulent diffusion between the active (heat) and passive (mass) scalars in a thermally stably stratified medium is investigated. The axisymmetric problem is treated on the formation of a turbulent circulation flow above a heated disk and on the turbulent diffusion of a passive scalar (impurity) from a continuous surface source in a stably stratified medium. The results indicate that the thermal stratification causes appreciable differences in the coefficients of turbulent transfer between the active (heat) and passive (mass) scalars. This means that the assumption of the identity of the coefficient of turbulent diffusion of heat and mass, employed in conventional models of turbulence, produces significant errors in estimating the heat and mass transfer in a thermally stably stratified medium. 相似文献
5.
S. M. Nikonov I. V. Elkin I. A. Lipatov A. V. Basov A. V. Kapustin A. A. Rovnov 《Power Technology and Engineering (formerly Hydrotechnical Construction)》2007,41(6):351-354
Results of experiments conducted on a large-scale integral PSB-VVéR bench and directed toward investigation of the performance
of new passive safety systems for nuclear plants with a water-cooled power reactor, an additional system for passive flooding
of the active zone, and a system for the passive removal of heat from steam generators are presented.
__________
Translated from élektricheskie Stantsii, No. 9, September 2007, pp. 7–10. 相似文献
6.
7.
单站被动定位及光电实现 总被引:1,自引:0,他引:1
目的 光电技术实现的单站被动定位具有重要的军事价值 ,本文介绍了其原理、方法和发展 .方法 本文中 ,单站被动定位分为激光和红外两部分内容讨论 .结果 明确了采用激光和红外技术的单站被动定位工作原理和存在的技术难点 ,同时 ,指出了被动定位的研究动向 .结论 文章表明单站被动定位及光电实现值得进一步研究 . 相似文献
8.
EPON技术具有大带宽、高性价比、结构简单和一定服务质量保证等特点,被业界普遍看好,成为 下一代接入网的最佳候选技术.本文主要介绍了EPON的工作原理、分层结构、接入控制和组帧方式,最后给出 了实现EPON的关键技术和难点以及EPON的发展近况. 相似文献
9.
介绍光电被动感应控制开关模块工作原理,研究开发了一种基于被动感应控制原理的自动冲水控制装置,总结比较了主动感应控制与被动感应控制的优缺点及其应用特点。 相似文献
10.
无源软开关电路拓扑的研究 总被引:1,自引:0,他引:1
提出一个研究无源软开关电路的新技术方法;其特征是对基本的单管隔离型PWM DC/DC变换器进行类比分析,由此直接导出可行的缓冲能量再生复位电路.该新方法能使DC/DC PWM硬开关变换器转变为软开关变换器.以新型Boost无源软开关变换器为例,进行了电路理论分析与中功率样机的实验测试;结果表明此新变换器具有较宽的软开关工作范围、较低的电应力、较小的缓冲元件量值等特点.由此认为,这种研究方法推导简单、物理意义清晰,还能深入地研究无源软开关的新电路拓扑. 相似文献