Slow eroding biodegradable multiblock poloxamer copolymers

Biodegradable multiblock poloxamers (BMPs) with gel duration of 8 h to several weeks were prepared by varying their molecular weights from 4000 to 40 000 g mol^?1. The molecular weight of the BMP was controlled by changing the poloxamer to coupling agent ratio. Assuming a micelle packing model of the BMP gel, as in the case of a poloxamer gel, the micelle properties and critical gel concentration of BMPs were investigated on the basis of the scaling concept. The findings suggest that the control of molecular weight by hydrolyzable groups can be a facile approach to optimize the gel properties for biomedical applications. Copyright © 2005 Society of Chemical Industry     

汽车空调制冷系统中应用R407C的分析

本文对混合工质R407C与R12的物理和热力性质进行了比较分析，并针对汽车空调制冷系统的特点，对两种工质在变工况下进行了制冷系统的理论循环分析，阐明了在汽车空调制冷系统中使用R407C的可行性。     

R407系列产品专利研究

介绍了杜邦公司R407系列产品专利申请、授权和专利权有效期情况。     

基于STM32F407和OV7670的低端视频监控系统

本系统采用了意法半导体公司的STM32F407微处理器作为核心,以OV7670作为监控系统的视频采集传感器,并将传感器采集的数据通过DMA控制器成功地发送至液晶模块(SSD1289)显示。该系统运行流畅,为低端视频监控系统提供了一种新的解决方案。     

Formulation and development of ophthalmic in situ gel for the treatment ocular inflammation and infection using application of quality by design concept

Context: The conventional liquid ophthalmic delivery systems exhibit short pre-corneal residence time and the relative impermeability to the cornea which leads to poor ocular bioavailability.

Objective: The aim of this study was to apply quality by design (QbD) for development of dexamethasone sodium phosphate (DSP) and tobramycin sulfate (TS)-loaded thermoresponsive ophthalmic in situ gel containing Poloxamer 407 and hydroxyl propyl methyl cellulose (HPMC) K4M for prolonging the pre-corneal residence time, ocular bioavability and decreases the frequency of administration of dosage form. The material attributes and the critical quality attributes (CQA) of the in situ gel were identified. Central composite design (CCD) was adopted to optimize the formulation.

Materials and methods: The ophthalmic in situ forming gels were prepared by cold method. Materials attributes were the amount of Poloxamer 407 and HPMC and CQA identified were Gel strength, mucoadhesive index, gelation temperature and % of drug release of both drug.

Results and discussion: Optimized batch (F*) containing 16.75% poloxamer 407 and 0.54% HPMC K4M were exhibited all results in acceptable limits. Compared with the marketed formulation, optimized in situ gel showed delayed T_max, improved C_max and AUC in rabbit aqueous humor, suggesting the sustained drug release and better corneal penetration and absorption.

Conclusion: According to the study, it could be concluded that DSP and TS would be successfully formulated as in situ gelling mucoadhesive system for the treatment of steroid responsive eye infections with the properties of sustained drug release, prolonged ocular retention and improved corneal penetration.     

基于跳频和同步捕获技术的水下无线通信技术研究

本文所阐述的水下无线技术即基于跳频技术和同步捕获技术的水声通信,由于声波在海水中的传播特性显著优越于电磁波和可见光,使得水声技术成为海洋高技术的主要研究领域之一 ,在国防领域也具有十分重要的研究意义.本文主要论述了水声通信中跳频技术和同步捕获技术的原理、具体算法的实现方案以及部分硬件设施的使用简述,并通过展示实验结果验证算法的可行性.     

Viscosity of Alternative Refrigerants R407C and R407E in the Vapor Phase from 298.15 to 423.15 K

This paper presents new measurements of the viscosity of gaseous R407C (23 mass% HFC-32, 25 mass% HFC-125, 52 mass% HFC-143a) and R407E (25 mass% HFC-32, 15 mass% HFC-125, 60 mass% HFC-143a). The measurements were carried out with an oscillating-disk viscometer of the Maxwell type at temperatures from 298.15 to 423.15 K. The densities of these two fluid mixtures were calculated with the equation-of-state model in REFPROP. The viscosity at normal pressures was analyzed with the extended law of corresponding states developed by Kestin et al., and the scaling parameters needed in the analysis were obtained from our previous studies for the viscosity of the binary mixtures consisting of HFC-32, HFC-125, and HFC-134a. The modified Enskog theory developed by Vesovic and Wakeham (V-W method) was applied to predict the viscosity for the ternary gaseous HFC mixtures under pressure. As for the calculation of pseudo-radial distribution functions in mixtures, a method based on the equation of state for hard-sphere fluid mixtures proposed by Carnahan-Starling was applied. It was found that the V-W method can predict the viscosity of R407C and R407E without any additional parameters for the ternary mixture.     

Reasons for drop in shell-and-tube condenser performance when replacing R22 with zeotropic mixtures. Part 1. Analysis of experimental findings

An experimental and theoretical investigation was made to find out the reasons for the drop in shell-and-tube condenser performance when replacing R22 with a zeotropic mixture R407C. Measurements show that at lower condenser loads the reduction in performance can be as large as 70% compared to the full condenser load. Calculation results are compared with experimental results for two different condensers, one with micro-finned tubes and one with 3-D finned tubes. Calculations show that the degree of mixing of the newly formed condensate on a tube and the drained condensate is a factor influential enough to explain the performance drop. 3-D finned tubes seem to have better mixing in the condensate than integral finned tubes.     

R407C房间空调器系统性能模拟与换热部件

对替代房间空调器用制冷剂R22的R407C工质的应用进行了研究,分别建立了空调器主要部件(蒸发器、冷凝器、压缩机、毛细管和连接管道)的分布参数模型(除压缩机模型外), 并对空调器进行了模拟.且就换热器的结构参数编制了优化模块,获得了一些有参考价值的研究结果.     

Pseudo-Pure Fluid Equations of State for the Refrigerant Blends R-410A, R-404A, R-507A, and R-407C

Pseudo-pure fluid equations of state explicit in Helmholtz energy have been developed to permit rapid calculation of the thermodynamic properties of the refrigerant blends R-410A, R-404A, R-507A, and R-407C. The equations were fitted to values calculated from a mixture model developed in previous work for mixtures of R-32, R-125, R-134a, and R-143a. The equations may be used to calculate the single-phase thermodynamic properties of the blends; dew and bubble point properties are calculated with the aid of additional ancillary equations for the saturation pressures. Differences between calculations from the pseudo-pure fluid equations and the full mixture model are on average 0.01%, with all calculations less than 0.1% in density except in the critical region. For the heat capacity and speed of sound, differences are on average 0.1% with maximum differences of 0.5%. Generally, these differences are consistent with the accuracy of available experimental data for the mixtures, and comparisons are given to selected experimental values to verify accuracy estimates. The equations are valid from 200 to 450 K and can be extrapolated to higher temperatures. Computations from the new equations are up to 100 times faster for phase equilibria at a given temperature and 5 times faster for single-phase state points given input conditions of temperature and pressure.